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A description of th...
A description of the clinical characteristics at baseline of patients recruited into the Carvedilol or Metoprolol European Trial (COMET)
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Cleland, J. G. (author)
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Goode, K. (author)
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- Erhardt, Leif RW (author)
- Lund University,Lunds universitet,Internmedicin - epidemiologi,Forskargrupper vid Lunds universitet,Internal Medicine - Epidemiology,Lund University Research Groups
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Remme, W. J. (author)
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Charlesworth, A. (author)
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Poole-Wilson, P. A. (author)
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Di Lenarda, A. (author)
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Hanrath, P. (author)
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Komajda, M. (author)
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Metra, M. (author)
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- Swedberg, Karl, 1944 (author)
- Gothenburg University,Göteborgs universitet,Hjärt-kärlinstitutionen,Cardiovascular Institute
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Torp-Pedersen, C. (author)
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Trop-Pedersen, C (author)
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(creator_code:org_t)
- 2004
- 2004
- English.
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In: Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy. - 0920-3206. ; 18:2, s. 139-52
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Abstract
Subject headings
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- BACKGROUND & AIMS: The COMET trial was a prospective, double-blind, randomised trial comparing carvedilol, a comprehensive adrenergic receptor antagonist, with metoprolol, a beta-1-selective agent in patients with heart failure and left ventricular systolic dysfunction. The trial showed a reduction in mortality with carvedilol that was consistent across subgroups. The purpose of this report is to describe in greater detail the heterogeneity of this population at baseline with particular reference to the impact of symptomatic severity, age and gender on patient characteristics. METHODS: A descriptive report using data entered in the COMET study data-base. RESULTS: The characteristics of the population studied were similar to those reported in previous trials of beta-blockers. Almost all patients were receiving diuretics and ACE inhibitors with few patients taking angiotensin receptor blockers. As expected, older patients had more co-morbidity. Older patients and women reported worse symptoms and poorer well-being despite similar ventricular dimensions and systolic dysfunction. NT-proBNP was higher in patients with more severe symptoms and older patients but not in women, although differences in NT-proBNP may have been confounded by differences in renal function. CONCLUSION: Age and gender, as well as the severity of cardiac dysfunction, appear to have an important effect on the severity of heart failure symptoms and patient 'well-being'. This could have important implications for the relationship between symptoms and prognosis and therefore the way in which patients are selected for clinical trials and the goals of treatment. This will be the subject of further analyses.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Annan klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Other Clinical Medicine (hsv//eng)
Keyword
- Adrenergic beta-Antagonists/*therapeutic use
- Age Factors
- Aged
- Body Mass Index
- Carbazoles/*therapeutic use
- Comorbidity
- Double-Blind Method
- Female
- Heart Failure
- Congestive/classification/*drug therapy/etiology
- Humans
- Male
- Metoprolol/*therapeutic use
- Middle Aged
- Patient Selection
- Propanolamines/*therapeutic use
- Randomized Controlled Trials
- Severity of Illness Index
- Sex Factors
- heart failure
- metoprolol
- carvedilol
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Cleland, J. G.
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Goode, K.
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Erhardt, Leif RW
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Remme, W. J.
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Charlesworth, A.
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Poole-Wilson, P. ...
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show more...
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Di Lenarda, A.
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Hanrath, P.
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Komajda, M.
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Metra, M.
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Swedberg, Karl, ...
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Torp-Pedersen, C ...
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Trop-Pedersen, C
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cardiac and Card ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Other Clinical M ...
- Articles in the publication
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Cardiovascular d ...
- By the university
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University of Gothenburg
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Lund University