Sökning: WFRF:(Gooding Kim M.)
> (2024) >
Type 2 diabetes exa...
Type 2 diabetes exacerbates changes in blood pressure-independent arterial stiffness : cross-sectional and longitudinal evidence from the SUMMIT study
-
- Aizawa, Kunihiko (författare)
- University of Exeter
-
- Gates, Phillip E. (författare)
- University of Exeter
-
- Mawson, David M. (författare)
- University of Exeter
-
visa fler...
-
- Casanova, Francesco (författare)
- University of Exeter
-
- Gooding, Kim M. (författare)
- University of Exeter
-
- Hope, Suzy V. (författare)
- University of Exeter
-
- Goncalves, Isabel (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
-
- Nilsson, Jan (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - immunitet och ateroskleros,Forskargrupper vid Lunds universitet,Cardiovascular Research - Immunity and Atherosclerosis,Lund University Research Groups
-
- Khan, Faisel (författare)
- University of Dundee
-
- Colhoun, Helen M. (författare)
- University of Edinburgh
-
- Natali, Andrea (författare)
- University of Pisa
-
- Palombo, Carlo (författare)
- University of Pisa
-
- Shore, Angela C. (författare)
- University of Exeter
-
visa färre...
-
(creator_code:org_t)
- 2024
- 2024
- Engelska 10 s.
-
Ingår i: Journal of Applied Physiology. - 8750-7587. ; 136:1, s. 13-22
- Relaterad länk:
-
http://dx.doi.org/10... (free)
-
visa fler...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Greater central artery stiffness is observed in people with type 2 diabetes (T2DM). Elevated blood pressure (BP) and altered arterial wall structure/composition in T2DM are generally considered as main drivers for this alteration. However, because conventional arterial stiffness measures are BP-dependent and as such an influence of BP remains in a measure, it is unclear if greater central artery stiffness is a function of greater BP, or due to changes in the structure and composition of the arterial wall. We aimed to measure BP-independent arterial stiffness (b0) cross-sectionally and longitudinally in T2DM. We studied 753 adults with T2DM (DM þ) and 436 adults without (DM-) at baseline (Phase 1), and 310 DM þ and 210 DM- adults at 3-yr follow-up (Phase 2). We measured carotid-femoral pulse wave velocity and used it to calculate b0. In Phase 1, b0 was significantly greater in DM þ than DM- after adjusting for age and sex [27.5 (26.6–28.3) vs. 23.6 (22.4–24.8) au, P < 0.001]. Partial correlation analyses after controlling for age and sex showed that b0 was significantly associated with hemoglobin A1c (r ¼ 0.15 P < 0.001) and heart rate [(HR): r ¼ 0.23 P < 0.001)] in DM þ . In Phase 2, percentage-change in b0 was significantly greater in DM þ than DM-[19.5 (14.9–24.0) vs. 5.0 (-0.6 to 10.6) %, P < 0.001] after adjusting for age, sex, and baseline b0. b0 was greater in DM þ than DM- and increased much more in DM þ than in DM- over 3 yr. This suggests that T2DM exacerbates BP-independent arterial stiffness and may have a complemental utility to existing arterial stiffness indices. NEW & NOTEWORTHY We demonstrate in this study a greater BP-independent arterial stiffness b0 in people with type 2 diabetes (T2DM) compared to those without, and also a greater change in b0 over 3 yr in people with T2DM than those without. These findings suggest that the intrinsic properties of the arterial wall may change in a different and more detrimental way in people with T2DM and likely represents accumulation of cardiovascular risk.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- aging
- aorta
- blood pressure
- ultrasound
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Aizawa, Kunihiko
-
Gates, Phillip E ...
-
Mawson, David M.
-
Casanova, France ...
-
Gooding, Kim M.
-
Hope, Suzy V.
-
visa fler...
-
Goncalves, Isabe ...
-
Nilsson, Jan
-
Khan, Faisel
-
Colhoun, Helen M ...
-
Natali, Andrea
-
Palombo, Carlo
-
Shore, Angela C.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
Journal of Appli ...
- Av lärosätet
-
Lunds universitet