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Haemorheological re...
Haemorheological result in a large multicentre study of claudicants treated with ketanserin
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- Nash, Gerard (författare)
- St George´s Hospital, London, England
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- Dormandy, John (författare)
- St George´s Hospital, London, England
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- Juhan-Vague, I (författare)
- Hopital de la Timone, Marseilles, France
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- Billerey, M (författare)
- Hopital de la Timone, Marseilles, France
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- Rieger, H (författare)
- Klinik fur Gefasskrankheiten, Engelskirchen, FRG
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- Scheffler, A (författare)
- Klinik fur Gefasskrankheiten, Engelskirchen, FRG
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- Coccheri, S (författare)
- Department of Angiology, University Hospital, Bologna, Italy
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- Palaretti, G (författare)
- Department of Angiology, University Hospital, Bologna, Italy
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- Poggi, M (författare)
- Department of Angiology, University Hospital, Bologna, Italy
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- Lowe, Gordon (författare)
- Royal Infirmary, Glasgow, Scotland
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- Lennie, Susan (författare)
- Royal Infirmary, Glasgow, Scotland
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- Larsson, Hans (författare)
- Department of Internal Medicine, University Hospital, Lund, Sweden
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- Persson, Sylvi (författare)
- Department of Internal Medicine, University Hospital, Lund, Sweden
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(creator_code:org_t)
- New York, USA : Pergamon Press, 1990
- 1990
- Engelska.
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Ingår i: Clinical Hemorheology. - New York, USA : Pergamon Press. - 0271-5198. ; 10, s. 321-327
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
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- Abstract An international, multi-centre trial was carried out to test the haemorheological effects of ketanserin, a serotonin antagonist, after treatment of intermittent claudicants for 1 year. Haematological indices, whole blood viscosity, plasma viscosity and red cell and white cell filterabi1ity were measured using standardised techniques. Even so, inter-laboratory variability, and intra-laboratory changes in control values in some centres over the 1 year period proved to be major obstacles. The pooled data showed no evidence of haemorheological changes, although data from the single largest centre indicated slightly lowered haematocrit and blood and plasma viscosity. Any rheological effects of serotonin antagonists in intermittent claudicants are probably small and unlikely to be the main source of any clinical efficacy. In general, it would appear that standardisation and monitoring of laboratory techniques must be strictly carried out if there is to be any hope of successfully carrying out multi-centre haemorheological trials. . Key words: Blood Rheology; Claudication; Serotonin Antagonists;
Nyckelord
- Blood Rheology; Claudication; Serotonin Antagonists
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Nash, Gerard
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Dormandy, John
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Juhan-Vague, I
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Billerey, M
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Rieger, H
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Scheffler, A
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visa fler...
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Coccheri, S
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Palaretti, G
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Poggi, M
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Lowe, Gordon
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Lennie, Susan
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Larsson, Hans
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Persson, Sylvi
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