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Sökning: WFRF:(Gorman T) > (2005-2009)

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  • Forabosco, P., et al. (författare)
  • Meta-analysis of genome-wide linkage studies of systemic lupus erythematosus
  • 2006
  • Ingår i: Genes and Immunity. - : Springer Science and Business Media LLC. - 1466-4879 .- 1476-5470. ; 7:7, s. 609-614
  • Tidskriftsartikel (refereegranskat)abstract
    • A genetic contribution to the development of systemic lupus erythematosus (SLE) is well established. Several genome-wide linkage scans have identified a number of putative susceptibility loci for SLE, some of which have been replicated in independent samples. This study aimed to identify the regions showing the most consistent evidence for linkage by applying the genome scan meta-analysis (GSMA) method. The study identified two genome-wide suggestive regions on 6p21.1-q15 and 20p11-q13.13 (P-value=0.0056 and P-value=0.0044, respectively) and a region with P-value<0.01 on 16p13-q12.2.The region on chromosome 6 contains the human leukocyte antigen cluster, and the chromosome 16 and 20 regions have been replicated in several cohorts. The potential importance of the identified genomic regions are also highlighted. These results, in conjunction with data emerging from dense single nucleotide polymorphism typing of specific regions or future genome-wide association studies will help guide efforts to identify the actual predisposing genetic variation contributing to this complex genetic disease.
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  • Sathre, Roger, et al. (författare)
  • Improving the performance of wooden journal bearings
  • 2005
  • Ingår i: Forest Products Journal. - 0015-7473. ; 55:11, s. 41-47
  • Tidskriftsartikel (refereegranskat)abstract
    • Journal bearings made of wood have long been used in traditional devices such as oxcarts and waterwheels. They are currently used in industrial materials-handling equipment and other specialized applications. Wooden bearings have potential use in developing regions in appropriate technology devices such as animal-drawn carts and manual water pumps. This pilot study examined a number of factors that affect wooden bearing performance, including wood properties, fabrication methods, and operating conditions. A testing procedure for wooden bearings was established, and a testing machine was constructed. Bearings were fabricated of different wood species, treated with various lubricants, and run on the machine under varying conditions of load and speed. Measurements were made of bearing and axle wear, static and dynamic friction. and bearing operating temperature. The results of this study show that lubricant characteristics, speed and load of operation, steel axle properties, and wood density and permeability can have a considerable effect on bearing performance.
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