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Incremental prognos...
Incremental prognostic value of multichamber deformation imaging and renal function status to predict adverse outcome in heart failure with reduced ejection fraction
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- Saha, Samir Kanti (författare)
- Umeå universitet,Kardiologi
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- Luo, Xia-Xia (författare)
- Department of Ultrasonography, Shenzhen Hospital, Southern Medical University, Shenzhen, China; Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
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- Gopal, Aasha S. (författare)
- St. Francis Hospital, Roslyn NY, United States
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- Govind, Satish C. (författare)
- Fortis Hospitals, Bangalore, India
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- Fang, Fang (författare)
- Beijing Institute of Heart, Lung and Blood Vessel Diseases, Beijing Anzhen Hospital, Capital Medical University, Beijing, China
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- Liu, Ming (författare)
- Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China
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- Zhang, Qing (författare)
- Department of Cardiology, West China Hospital, Sichuan University, Chengdu, China
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- Ma, Chunyan (författare)
- Department of Cardiovascular Ultrasound, The First Hospital of China Medical University, Liaoning, China
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- Dong, Ming (författare)
- Department of Pathophysiology, School of Medicine, Shenzhen University, Shenzhen, China
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- Kiotsekoglou, Anatoli, 1960- (författare)
- Region Örebro län,Örebro universitet, Institutionen för medicinska vetenskaper,Department of Clinical Physiology
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- Yu, Cheuk-Man (författare)
- Department of Medicine and Therapeutics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong; Chiu Hin Kwong Heart Center, Hong Kong Baptist Hospital, Hong Kong, China
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(creator_code:org_t)
- 2018-02-04
- 2018
- Engelska.
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Ingår i: Echocardiography. - : John Wiley & Sons. - 0742-2822 .- 1540-8175. ; 35:4, s. 450-458
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Aims: Deformation imaging, particularly of left-sided heart, is fast becoming an essential tool in clinical cardiology. However, data are scant regarding the value of biventricular and bi-atrial deformation in association with comorbidities in heart failure with reduced left ventricular ejection fraction (HFREF).Methods and Results: Forty-nine subjects (72 +/- 13years; 28 male) with HFREF and 14 age-matched controls underwent deformation imaging including LV global longitudinal strain (LVGLS%), right ventricular strain (RVS%), and left atrial reservoir strain (LARS%). Standard echo parameters included LVEF%, E/E ratio, and pulmonary artery systolic pressure (PASP). Mean +/- SD of LVEF, LVGLS%, and RVS% were 31% +/- 8%, 7% +/- 3%, and 17% +/- 7%, respectively, and were significantly lower compared with controls (all P < .0001). Over a follow-up period of 4.2years, 24% of patients died and 48% had a composite outcome of death and heart failure hospitalization. In the logistic regression model, taking the composite of death and heart failure hospitalization as a dichotomous variable, RVS%, E/E ratio, and PASP were the only significant univariate predictors of adverse outcome (R-2 = .68, all P < .05). In the multivariate model, however, only PASP predicted adverse outcome. PASP also had the largest AUC (0.8) in the ROC analysis. A creatinine level of >88 mu mol/L (SCREAT) and a cutoff value of LA reservoir strain (LARS %) at <16.7% provided the best sensitivity (86%) and specificity (40%) with an odds ratio of 3.8. In the Kaplan-Meier survival estimate, LARS%-SCREAT predicted all-cause mortality and HF hospitalization.Conclusion: Multichamber deformation imaging along with renal function and PASP could best predict adverse outcome in HFREF.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- four-chamber strain
- heart failure with reduced ejection fraction
- left atrial strain
- left ventricular strain
- right atrial strain
- right ventricular strain
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Saha, Samir Kant ...
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Luo, Xia-Xia
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Gopal, Aasha S.
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Govind, Satish C ...
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Fang, Fang
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Liu, Ming
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Zhang, Qing
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Ma, Chunyan
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Dong, Ming
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Kiotsekoglou, An ...
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Yu, Cheuk-Man
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Echocardiography
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Örebro universitet
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Umeå universitet