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Open lung approach ...
Open lung approach versus standard protective strategies : Effects on driving pressure and ventilatory efficiency during anesthesia - A pilot, randomized controlled trial
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- Ferrando, Carlos (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Suarez-Sipmann, Fernando (författare)
- Uppsala universitet,Hedenstiernalaboratoriet,Inst Salud Carlos III, GIBER Enfermedades Resp, Madrid, Spain
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- Tusman, Gerardo (författare)
- Hosp Privado Comunidad Mar Del Plata, Dept Anesthesiol, Mar Del Plata, Buenos Aires, Argentina.
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- Leon, Irene (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Romero, Esther (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Gracia, Estefania (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Mugarra, Ana (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Arocas, Blanca (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Pozo, Natividad (författare)
- Hosp Clin Univ, INCLIVA Clin Res Inst, Valencia, Spain.
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- Soro, Marina (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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- Belda, Francisco J. (författare)
- Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain.
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Hosp Clin Univ, Dept Anesthesiol & Crit Care, Valencia, Spain Hedenstiernalaboratoriet (creator_code:org_t)
- 2017-05-11
- 2017
- Engelska.
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Ingår i: PLOS ONE. - : PUBLIC LIBRARY SCIENCE. - 1932-6203. ; 12:5
- Relaterad länk:
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https://doi.org/10.1...
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https://uu.diva-port... (primary) (Raw object)
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https://journals.plo...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Low tidal volume (VT) during anesthesia minimizes lung injury but may be associated to a decrease in functional lung volume impairing lung mechanics and efficiency. Lung recruitment (RM) can restore lung volume but this may critically depend on the post-RM selected PEEP. This study was a randomized, two parallel arm, open study whose primary outcome was to compare the effects on driving pressure of adding a RM to low-VT ventilation, with or without an individualized post-RM PEEP in patients without known previous lung disease during anesthesia.Methods: Consecutive patients scheduled for major abdominal surgery were submitted to low-VT ventilation (6 ml.kg(-1)) and standard PEEP of 5 cmH(2)O (pre-RM, n = 36). After 30 min estabilization all patients received a RM and were randomly allocated to either continue with the same PEEP (RM-5 group, n = 18) or to an individualized open-lung PEEP (OL-PEEP) (Open Lung Approach, OLA group, n = 18) defined as the level resulting in maximal Cdyn during a decremental PEEP trial. We compared the effects on driving pressure and lung efficiency measured by volumetric capnography.Results: OL-PEEP was found at 8 +/- 2 cmH(2)O. 36 patients were included in the final analysis. When compared with pre-RM, OLA resulted in a 22% increase in compliance and a 28% decrease in driving pressure when compared to pre-RM. These parameters did not improve in the RM-5. The trend of the DP was significantly different between the OLA and RM-5 groups (p = 0.002). VDalv/VTalv was significantly lower in the OLA group after the RM (p = 0.035).Conclusions: Lung recruitment applied during low-VT ventilation improves driving pressure and lung efficiency only when applied as an open-lung strategy with an individualized PEEP in patients without lung diseases undergoing major abdominal surgery.
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Ferrando, Carlos
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Suarez-Sipmann, ...
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Tusman, Gerardo
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Leon, Irene
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Romero, Esther
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Gracia, Estefani ...
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Mugarra, Ana
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Arocas, Blanca
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Pozo, Natividad
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Soro, Marina
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Belda, Francisco ...
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Uppsala universitet