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Sökning: WFRF:(Grad Yonatan H.) > (2019) > The impact of antim...

The impact of antimicrobials on gonococcal evolution

Sánchez-Busó, Leonor (författare)
Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Golparian, Daniel, 1984- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology
Corander, Jukka (författare)
Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK: Helsinki Institute for Information Technology, Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland; Department of Biostatistics, University of Oslo, Oslo, Norway
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Grad, Yonatan H. (författare)
Department of Immunology and Infectious Diseases, Harvard TH Chan School of Public Health, Boston, MA, USA; Division of Infectious Diseases, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Ohnishi, Makoto (författare)
Department of Bacteriology I, National Institute of Infectious Diseases, Tokyo, Japan; Antimicrobial Resistance Research Center, National Institute of Infectious Diseases, Tokyo, Japan
Flemming, Rebecca (författare)
Faculty of Classics, University of Cambridge, Cambridge, UK
Parkhill, Julian (författare)
Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Bentley, Stephen D. (författare)
Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
Unemo, Magnus, 1970- (författare)
Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,WHO Collaborating Centre for Gonorrhoea and other Sexually Transmitted Infections, National Reference Laboratory for Sexually Transmitted Infections, Department of Laboratory Medicine, Clinical Microbiology
Harris, Simon R. (författare)
Pathogen Genomics, Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK
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 (creator_code:org_t)
2019-07-29
2019
Engelska.
Ingår i: Nature Microbiology. - : Nature Publishing Group. - 2058-5276. ; 4:11, s. 1941-1950
Relaterad länk:
https://europepmc.or...
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https://urn.kb.se/re...
https://doi.org/10.1...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • The sexually transmitted pathogen Neisseria gonorrhoeae is regarded as being on the way to becoming an untreatable superbug. Despite its clinical importance, little is known about its emergence and evolution, and how this corresponds with the introduction of antimicrobials. We present a genome-based phylogeographical analysis of 419 gonococcal isolates from across the globe. Results indicate that modern gonococci originated in Europe or Africa, possibly as late as the sixteenth century and subsequently disseminated globally. We provide evidence that the modern gonococcal population has been shaped by antimicrobial treatment of sexually transmitted infections as well as other infections, leading to the emergence of two major lineages with different evolutionary strategies. The well-described multidrug-resistant lineage is associated with high rates of homologous recombination and infection in high-risk sexual networks. A second, multisusceptible lineage is more associated with heterosexual networks, with potential implications for infection control.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Infectious Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

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