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Associations of est...
Associations of estimated glomerular filtration rate and albuminuria with mortality and renal failure by sex : a meta-analysis
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Nitsch, Dorothea (författare)
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Grams, Morgan (författare)
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Sang, Yingying (författare)
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Black, Corri (författare)
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Cirillo, Massimo (författare)
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Djurdjev, Ognjenka (författare)
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Iseki, Kunitoshi (författare)
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Jassal, Simerjot K (författare)
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Kimm, Heejin (författare)
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Kronenberg, Florian (författare)
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Oien, Cecilia M (författare)
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Levey, Andrew S (författare)
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Levin, Adeera (författare)
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Woodward, Mark (författare)
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Hemmelgarn, Brenda R (författare)
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- Larsson, Anders (bidragsgivare)
- Uppsala universitet,Biokemisk struktur och funktion
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(creator_code:org_t)
- 2013-01-29
- 2013
- Engelska.
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Ingår i: The BMJ. - : BMJ. - 1756-1833. ; 346, s. f324-
- Relaterad länk:
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https://www.bmj.com/...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- OBJECTIVE: To assess for the presence of a sex interaction in the associations of estimated glomerular filtration rate and albuminuria with all-cause mortality, cardiovascular mortality, and end stage renal disease.DESIGN: Random effects meta-analysis using pooled individual participant data.SETTING: 46 cohorts from Europe, North and South America, Asia, and Australasia.PARTICIPANTS: 2,051,158 participants (54% women) from general population cohorts (n=1,861,052), high risk cohorts (n=151,494), and chronic kidney disease cohorts (n=38,612). Eligible cohorts (except chronic kidney disease cohorts) had at least 1000 participants, outcomes of either mortality or end stage renal disease of ≥ 50 events, and baseline measurements of estimated glomerular filtration rate according to the Chronic Kidney Disease Epidemiology Collaboration equation (mL/min/1.73 m(2)) and urinary albumin-creatinine ratio (mg/g).RESULTS: Risks of all-cause mortality and cardiovascular mortality were higher in men at all levels of estimated glomerular filtration rate and albumin-creatinine ratio. While higher risk was associated with lower estimated glomerular filtration rate and higher albumin-creatinine ratio in both sexes, the slope of the risk relationship for all-cause mortality and for cardiovascular mortality were steeper in women than in men. Compared with an estimated glomerular filtration rate of 95, the adjusted hazard ratio for all-cause mortality at estimated glomerular filtration rate 45 was 1.32 (95% CI 1.08 to 1.61) in women and 1.22 (1.00 to 1.48) in men (P(interaction)<0.01). Compared with a urinary albumin-creatinine ratio of 5, the adjusted hazard ratio for all-cause mortality at urinary albumin-creatinine ratio 30 was 1.69 (1.54 to 1.84) in women and 1.43 (1.31 to 1.57) in men (P(interaction)<0.01). Conversely, there was no evidence of a sex difference in associations of estimated glomerular filtration rate and urinary albumin-creatinine ratio with end stage renal disease risk.CONCLUSIONS: Both sexes face increased risk of all-cause mortality, cardiovascular mortality, and end stage renal disease with lower estimated glomerular filtration rates and higher albuminuria. These findings were robust across a large global consortium.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
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Nitsch, Dorothea
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Grams, Morgan
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Sang, Yingying
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Black, Corri
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Cirillo, Massimo
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Djurdjev, Ognjen ...
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visa fler...
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Iseki, Kunitoshi
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Jassal, Simerjot ...
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Kimm, Heejin
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Kronenberg, Flor ...
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Oien, Cecilia M
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Levey, Andrew S
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Levin, Adeera
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Woodward, Mark
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Hemmelgarn, Bren ...
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Larsson, Anders
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visa färre...
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Uppsala universitet