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Favorable Outcome i...
Favorable Outcome in Patients with Pheochromocytoma and Paraganglioma Treated with 177Lu-DOTATATE.
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- Vyakaranam, Achyut Ram (författare)
- Uppsala universitet,Radiologi
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- Crona, Joakim (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Norlén, Olov (författare)
- Uppsala universitet,Endokrinkirurgi
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- Granberg, Dan (författare)
- Karolinska Institutet,Uppsala universitet,Onkologisk endokrinologi
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- Garske-Román, Ulrike, 1963- (författare)
- Uppsala universitet,Radiologi,Sahlgrens Univ Hosp, Dept Nucl Med, Gothenburg, Sweden
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- Sandström, Mattias (författare)
- Uppsala universitet,Radiologi
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- Fröss-Baron, Katarzyna (författare)
- Uppsala universitet,Endokrin tumörbiologi
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- Thiis-Evensen, Espen (författare)
- Oslo Univ Hosp, Rikshosp, Dept Gastroenterol, Oslo, Norway
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- Hellman, Per (författare)
- Uppsala universitet,Endokrinkirurgi
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- Sundin, Anders, 1954- (författare)
- Uppsala universitet,Radiologi
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(creator_code:org_t)
- 2019-06-28
- 2019
- Engelska.
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Ingår i: Cancers. - : MDPI AG. - 2072-6694. ; 11:7
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://res.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- Peptide receptor radiotherapy (PRRT) with 177Lu-DOTATATE has emerged as a promising therapy for neuroendocrine tumors (NETs). This retrospective cohort study aimed to assess the outcome of PRRT for 22 patients with histopathologically confirmed pheochromocytoma (PCC) and paraganglioma (PGL), of which two were localized and 20 metastatic. Radiological response utilized response evaluation criteria in solid tumors 1.1 and toxicity was graded according to common terminology criteria for adverse events version 4. Median 4 (range 3-11) 7.4 GBq cycles of 177Lu-DOTATATE were administered as first-line therapy (n = 13) or because of progressive disease (n = 9). Partial response (PR) was achieved in two and stable disease (SD) in 20 patients. The median overall survival (OS) was 49.6 (range 8.2-139) months and median progression-free survival (PFS) was 21.6 (range 6.7-138) months. Scintigraphic response >50% was achieved in 9/19 (47%) patients. Biochemical response (>50% decrease) of chromogranin A was found in 6/15 (40%) patients and of catecholamines in 3/12 (25%) patients. Subgroup analysis showed Ki-67 <15% associated with longer OS (p = 0.013) and PFS (p = 0.005). PRRT as first-line therapy was associated with increased OS (p = 0.041). No hematological or kidney toxicity grade 3-4 was registered. 177Lu-DOTATATE therapy was associated with favorable outcome and low toxicity. High Ki-67 (≥15%) and PRRT received because of progression on previous therapy could constitute negative predictive factors for OS.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- pheochromocytoma
- paraganglioma
- Lu-177-DOTATATE
- peptide receptor radiotherapy
- PRRT
- neuroendocrine tumor
- NET
- PCC
- PGL
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Cancers
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Vyakaranam, Achy ...
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Crona, Joakim
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Norlén, Olov
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Granberg, Dan
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Garske-Román, Ul ...
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Sandström, Matti ...
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Fröss-Baron, Kat ...
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Thiis-Evensen, E ...
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Hellman, Per
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Sundin, Anders, ...
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