| 1. |
- Karlsson, Edvin, et al.
(författare)
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Clonality of erythromycin resistance in Francisella tularensis
- 2016
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Ingår i: Journal of Antimicrobial Chemotherapy. - : Oxford University Press (OUP). - 0305-7453 .- 1460-2091. ; 71:10, s. 2815-2823
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: We analysed diverse strains of Francisella tularensis subsp. holarctica to assess if its division into biovars I and II is associated with specific mutations previously linked to erythromycin resistance and to determine the distribution of this resistance trait across this subspecies. Methods:Three-hundred and fourteen F. tularensis subsp. holarctica strains were tested for erythromycin susceptibility and whole-genome sequences for these strains were examined for SNPs in genes previously associated with erythromycin resistance. Each strain was assigned to a global phylogenetic framework using genome-wide canonical SNPs. The contribution of a specific SNP to erythromycin resistance was examined using allelic exchange. The geographical distribution of erythromycin-resistant F. tularensis strains was further investigated by literature search. Results:There was a perfect correlation between biovar II strains (erythromycin resistance) and the phylogenetic group B.12. Only B.12 strains had an AaEuroS -> aEuroSC SNP at position 2059 in the three copies of the rrl gene. Introducing 2059C into an rrl gene of an erythromycin-susceptible F. tularensis strain resulted in resistance. An additional 1144 erythromycin-resistant strains were identified from the scientific literature, all of them from Eurasia. Conclusions:Erythromycin resistance in F. tularensis is caused by an A2059C rrl gene mutation, which exhibits a strictly clonal inheritance pattern found only in phylogenetic group B.12. This group is an extremely successful clone, representing the most common type of F. tularensis throughout Eurasia.
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| 2. |
- Lindh, Magnus, 1960-
(författare)
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Regionen och EU? : Uppfattningar och attityder till EU-relaterade frågor i Västsverige
- 2016
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis explores perceptions and preferences on regional action in EU-related frameworks among regional actors in Western Sweden. Building upon the literature on Europeanisation and the Fusion approach, three dimensions of Europeanisation are clarified and explored– download, upload and crossload – and together with a set of five variables that constitute the Micro Fusion Framework; a comprehensive analytical tool is developed. The thesis analyses the intense debate among the members of West Sweden that took place from 2011 to 2013 that focused on how to functionally organise the regional office in Brussels in order to meet future challenges. Surprisingly, the members eventually decided to terminate their cooperation and close the jointly owned office in Brussels in spite of the fact that it has been widely regarded as successful and effective. Diverging perceptions and preferences is understood in terms of three positions on regional action; a download-, upload- and a coherent oriented position. Finally, the thesis presents the empirical findings and discusses in relation to three fusion scenarios, infusion, defusion and clustered fusion.In terms of Micro Fusion Framework, the dynamics shaping why West Sweden was finally regarded as a dysfunctional arena for regional action are explained by a shift of attention and action among regional actors in Western Sweden that led to pressure for further institutional adaptation in order to meet the demand of how ‘to get the best out of the EU’. Further, this redefinition of how to handle EU-affairs within the upload-oriented position was accompanied by positive attitudes towards the potential to bypass the state and thereby pursue regional priorities directly in Brussels given the compound nature of the EU. In contrast, those regional actors that are found to be more download-oriented often question the benefits of uploading activities in practice and advocate close relations to the state. A coherent oriented position recognises the importance of activities related to both of the vertical dimensions of Europeanisation.
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| 3. |
- Mobjörk, Malin, et al.
(författare)
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Facilitating Doctoral Education in Cross-disciplinary Milieus : Experiences from PhD-candidates
- 2019
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- Cross-disciplinarity shapes much research today and many PhD candidates areengaged in this research. The doctoral education is a formative phase in a scientist’sintellectual development. Despite a large body of research about cross-disciplinarity,less attention has focused on how cross-disciplinarity shapes doctoral education.This report explores the organisation of doctoral education in four cross-disciplinaryresearch milieus and the experiences of 14 PhD candidates enrolled in these milieus.One key finding is that PhD candidates are more comfortable when their educationhas involved meta-communication about conceptual approaches and experiencesof conducting cross-disciplinary research. This calls for research milieus’ providingdoctoral education in cross-disciplinary settings to take a deliberative approach.This will both benefit the PhD candidates and the research milieus, and is centralin the socialisation process of the next cadre of researchers and for the future ofcross-disciplinary research.
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| 4. |
- Sjöström, Jenny K., et al.
(författare)
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Procedure for Organic Matter Removal from Peat Samples for XRD Mineral Analysis
- 2019
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Ingår i: Wetlands (Wilmington, N.C.). - : Springer. - 0277-5212 .- 1943-6246. ; 39:3, s. 473-481
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Tidskriftsartikel (refereegranskat)abstract
- Ombrotrophic peatlands are recognized archives of past atmospheric mineral dust deposition. Net dust deposition rates, grain size, mineral hosts and source areas are typically inferred from down-core elemental data. Although elemental analysis can be time efficient and data rich, there are some inherent limitations. X-ray diffraction (XRD) analysis allowsdirect identification of mineral phases in environmental samples but few studies have applied this method to peat samples and a well-developed protocol for extracting the inorganic fraction of highly organic samples (>95%) is lacking. We tested and compared different levels of pre-treatment: no pre-treatment, thermal combustion (300, 350, 400, 450, 500 and 550 degrees C) and chemical oxidation (H2O2 and Na2S2O8) using a homogenised highly organic (>98%) composite peat sample. Subsequently, minerals were identified by XRD. The results show that combustion is preferred to chemical oxidation because it most efficiently removes organic matter (OM), an important pre-requisite for identifying mineral phases by XRD analysis. Thermally induced phase transitions can be anticipated when temperature is the only factor to take into consideration. Based on the data required in this studythe recommended combustion temperature is 500 degrees C which efficiently removes OM while preserving a majority of common dust minerals.
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| 5. |
- Öjehag-Pettersson, Andreas, 1979-
(författare)
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Space Craft : Globalization and Governmentality in Regional Development
- 2015
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- This thesis explores two related purposes. First, it theoretically investigates how the broad literature on globalization is nested in debates concerning the nature of concepts such as space and territory. When doing so, it suggests that studies of globalization can be advanced by escaping territorialist understandings where the nation state is reproduced as a natural arena appropriate for studying all aspects of ‘the social’.The theoretical part of the thesis is used as a basis for articulating a framework for empirical studies that rest upon a conceptual grammar fashioned through a combination of so called assemblage thinking and governmentality analysis. This framework is then put to work as the second, empirical, purpose of the thesis is pursued. More precisely this means that the governance of Swedish regional development is analyzed as an assemblage of discourses, practices and subjects where (re)production of globalization occurs.The (re)production of globalization is studied in three interrelated case studies, all based on a corpus of 81 documents pertaining to the governance of Swedish regional development. By paying attention to how power operates in terms of political rationalities, governmental technologies and the production of social actors, the thesis shows how notions of a perpetual and omnipresent global competition marks the assemblage with particularly salient modes of rationale. Specifically, entrepreneurship, innovation and creativity are represented as the primary means for becoming competitive in the age of globalization, and it is shown here how this have inclusionary and exclusionary effects in terms of desired social actors throughout Swedish regions. The thesis then ends with a concluding chapter where the current regimes of regional development are identified as complex forms of neoliberal rule with far reaching effects for democratic principles and practices.
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