| 1. |
|
|
| 2. |
|
|
| 3. |
- Giovannoni, Maria Paola, et al.
(författare)
-
Further studies on 2-arylacetamide pyridazin-3(2H)-ones: Design, synthesis and evaluation of 4,6-disubstituted analogs as formyl peptide receptors (FPRs) agonists.
- 2013
-
Ingår i: European journal of medicinal chemistry. - : Elsevier BV. - 1768-3254 .- 0223-5234. ; 64C, s. 512-528
-
Tidskriftsartikel (refereegranskat)abstract
- Formyl peptide receptors (FPRs) play an essential role in the regulation of endogenous inflammation and immunity. In the present studies, a large series of pyridazin-3(2H)-one derivatives bearing an arylacetamide chain at position 2 was synthesized and tested for FPR agonist activity. The pyridazin-3(2H)-one ring was confirmed to be an appropriate scaffold to support FPR agonist activity, and its modification at the 4 and 6 positions led to the identification of additional active agonists, which induced intracellular Ca(2+) flux in HL-60 cells transfected with either FPR1, FPR2, or FPR3. Seven formyl peptide receptor 1 (FPR1)-specific and several mixed FPR1/FPR2 dual agonists were identified with low micromolar EC50 values. Furthermore, these agonists also activated human neutrophils, inducing intracellular Ca(2+) flux and chemotaxis. Finally, molecular docking studies indicated that the most potent pyridazin-3(2H)-ones overlapped in their best docking poses with fMLF and WKYMVM peptides in the FPR1 and FPR2 ligand binding sites, respectively. Thus, pyridazinone-based compounds represent potential lead compounds for further development of selective and/or potent FPR agonists.
|
|
| 4. |
- Graziano, Maria, et al.
(författare)
-
Gesture production and speech fluency in competent speakers and language learners
- 2013
-
Ingår i: [Host publication title missing].
-
Konferensbidrag (refereegranskat)abstract
- It is often assumed that a main function of gestures is to compensate for expressive difficulties. This predicts that gestures should mainly occur with disfluent speech. However, surprisingly little is known about the relationship between gestures and fluent vs. disfluent speech. This study investigates the putative ompensatory role of gesture by examining competent speakers’ and language learners’ gestural production in fluent vs. non-fluent speech. Results show that both competent and less competent speakers predominantly produce gestures during fluent stretches of speech; ongoing gestures during disfluencies are suspended. In all groups, the few gestures that are completed during disfluencies are both referential and pragmatic. The findings strongly suggest that when speech stops, so do gestures, thus supporting the view of speech and gesture as an integrated system.
|
|
| 5. |
|
|
| 6. |
- Graziano, Maria, et al.
(författare)
-
‘Parallel gesturing’ in adult-child conversations
- 2011
-
Ingår i: Integrating gestures : the interdisciplinary nature of gesture / Gesture studies. - 1874-6829. - 9789027228451 ; 4, s. 89-102
-
Bokkapitel (refereegranskat)
|
|
| 7. |
|
|
