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Understanding and p...
Understanding and preventing type 1 diabetes through the unique working model of TrialNet
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- Battaglia, Manuela (författare)
- San Raffaele Scientific Institute
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- Anderson, Mark S (författare)
- University of California System
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- Buckner, Jane H. (författare)
- Benaroya Research Institute
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visa fler...
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- Geyer, Susan M. (författare)
- University of South Florida
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- Gottlieb, Peter A (författare)
- University of Colorado School of Medicine
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- Kay, Thomas W.H. (författare)
- University of Melbourne
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Celiaki och diabetes,Forskargrupper vid Lunds universitet,Celiac Disease and Diabetes Unit,Lund University Research Groups
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- Muller, Sarah (författare)
- University of South Florida
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- Pugliese, Alberto (författare)
- University of Miami
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- Roep, Bart O. (författare)
- Leiden University Medical Centre
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- Greenbaum, Carla J (författare)
- Benaroya Research Institute
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- Peakman, Mark (författare)
- King's College London
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visa färre...
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(creator_code:org_t)
- 2017-08-02
- 2017
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 60:11, s. 2139-2147
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Type 1 diabetes is an autoimmune disease arising from the destruction of pancreatic insulin-producing beta cells. The disease represents a continuum, progressing sequentially at variable rates through identifiable stages prior to the onset of symptoms, through diagnosis and into the critical periods that follow, culminating in a variable depth of beta cell depletion. The ability to identify the very earliest of these presymptomatic stages has provided a setting in which prevention strategies can be trialled, as well as furnishing an unprecedented opportunity to study disease evolution, including intrinsic and extrinsic initiators and drivers. This niche opportunity is occupied by Type 1 Diabetes TrialNet, an international consortium of clinical trial centres that leads the field in intervention and prevention studies, accompanied by deep longitudinal bio-sampling. In this review, we focus on discoveries arising from this unique bioresource, comprising more than 70,000 samples, and outline the processes and science that have led to new biomarkers and mechanistic insights, as well as identifying new challenges and opportunities. We conclude that via integration of clinical trials and mechanistic studies, drawing in clinicians and scientists and developing partnership with industry, TrialNet embodies an enviable and unique working model for understanding a disease that to date has no cure and for designing new therapeutic approaches.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Autoimmunity
- Mechanistic studies
- Review
- Type 1 diabetes
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Battaglia, Manue ...
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Anderson, Mark S
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Buckner, Jane H.
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Geyer, Susan M.
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Gottlieb, Peter ...
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Kay, Thomas W.H.
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visa fler...
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Lernmark, Åke
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Muller, Sarah
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Pugliese, Albert ...
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Roep, Bart O.
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Greenbaum, Carla ...
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Peakman, Mark
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visa färre...
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