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- Losa, M, et al.
(författare)
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Face morphogenesis is promoted by Pbx-dependent EMT via regulation of Snail1 during frontonasal prominence fusion
- 2018
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Ingår i: Development (Cambridge, England). - : The Company of Biologists. - 1477-9129 .- 0950-1991. ; 145:5
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Tidskriftsartikel (refereegranskat)abstract
- Human cleft lip with or without cleft palate (CL/P) is a common craniofacial abnormality caused by impaired fusion of the facial prominences. We have previously reported that in the mouse embryo epithelial apoptosis mediates fusion at the seam where the prominences coalesce. Here, we show that apoptosis alone is not sufficient to remove the epithelial layers. We observed morphological changes in the seam epithelia, intermingling of cells of epithelial descent into the mesenchyme, and molecular signatures of Epithelial-Mesenchymal-Transition (EMT). Utilizing mouse lines with cephalic epithelium-specific Pbx loss exhibiting CL/P, we demonstrate that these cellular behaviors are Pbx-dependent, as is the transcriptional regulation of the EMT driver Snail1. Furthermore, in the embryo the majority of epithelial cells expressing high levels of Snail1 do not undergo apoptosis. Pbx1 loss- and gain-of-function in a tractable epithelial culture system revealed that Pbx1 is both necessary and sufficient for EMT induction. This study establishes that Pbx-dependent EMT programs mediate murine upper lip/primary palate morphogenesis and fusion via regulation of Snail1. Of note, the EMT signatures observed in the embryo are mirrored in the epithelial culture system.
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| 3. |
- Vannikov, Anatoly, et al.
(författare)
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Photorefractive polymer composites for the IR region based on carbon nanotubes
- 2005
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Ingår i: Optics and Spectroscopy (English translation of Optika i Spektroskopiya). - : Pleiades Publishing Ltd. - 1562-6911 .- 0030-400X. ; 99:4, s. pp.643-648
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Tidskriftsartikel (refereegranskat)abstract
- The photorefractive properties of polymer composites based on aromatic polyimide and single-wall carbon nanotubes are studied using radiation at a wavelength of 1064 nm. It is found that the nanotubes possess photoelectric sensitivity in this spectral region and that the kinetic photorefractive characteristics of the polymer composites are entirely determined by the photogeneration and charge transport characteristics of the layers. The two-beam gain coefficient of the signal beam measured for a composite consisting of aromatic polyimide and 0.25 wt % of single-wall carbon nanotubes in a constant electric field E 0 = 79 V/μm is equal to 84 cm -1 and exceeds the optical absorption coefficient by 59 cm -1 . The refractive index modulation is equal to Δn = 0.004 at E 0 = 54 V/μm. © 2005 Pleiades Publishing, Inc.
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