| 1. |
- Balslev, Soren, et al.
(författare)
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Microfluidic dye laser with compact, low-cost liquid dye dispenser
- 2005
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Ingår i: Micro Total Analysis Systems 2004. - 0854048960 ; , s. 375-377
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Konferensbidrag (refereegranskat)abstract
- We present a compact system consisting of a miniaturized fluid dispenser, delivering liquid laser dye to a micro-chip dye laser. This demonstrates the elimination of bulk fluid pumps for a microfluidic system by using a miniaturized, electrically and chemically inert dispenser, capable of delivering very low flow for extended periods of time.
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| 2. |
- Roxhed, Niclas, et al.
(författare)
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Generic leak-free drug storage and delivery for microneedle-based systems
- 2005
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Ingår i: MEMS 2005 Miami. - 0780387325 ; , s. 742-745
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Konferensbidrag (refereegranskat)abstract
- We present a generic liquid packaging method for micromachined drug delivery systems with microneedles. Hollow microneedles are sealed with thin gold membranes at the openings on the needle tip on wafer level. This provides both a seal and an evaporation barrier to the drug delivery system on chip level. In addition, the membranes may also prevent drug delivery through needles that do not pierce the skin tissue. Applying a small voltage to the microneedle chip pressed onto the skin causes an electrochemical dissolving of membranes only at the needles that penetrated the skin tissue. The gold membrane sealed microneedles where tested for two types of operational modes. Opening the membranes by means of pressure showed that a minimum pressure of 125 kPa is needed to burst open the membranes. The removal of the gold membrane seal electrochemically was tested in vitro. The microneedle chip was opened within 2 min in the presence of an electrolyte comparable to the interstitial fluid.
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| 3. |
- Roxhed, Niclas, et al.
(författare)
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Reliable in-vivo penetration and transdermal injection using ultra-sharp hollow microneedles
- 2005
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Ingår i: Transducers '05, Digest of Technical Papers, Vols 1 and 2. - NEW YORK : IEEE. - 0780389948 ; , s. 213-216
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- Minimally invasive microneedles is a promising technology for painless drug administration through the human skin. However, not all microneedle structures are capable to penetrate human skin in a repeatable and reliable fashion at moderate insertion forces. In this work we present an ultra-sharp hollow microneedle array, tailored for enhanced and reliable skin penetration capability. The microneedle apex has a tip radius below 100 nm. We show penetration and sustainable injection of liquid dye into dry living human skin without the use of any penetration enhancers. Microneedle liquid injection was also tested on clinically relevant sites, such as the shoulder and the upper arm. The electrical impedance was measured between the microneedle and a counter electrode showing continuous changes in the measured values during the insertion.
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| 4. |
- Samel, Björn, et al.
(författare)
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Nanoliter liquid handling on a low cost disposable with embedded fluid actuators
- 2005
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Ingår i: Transducers '05, Digest of Technical Papers, Vols 1 and 2. - NEW YORK : IEEE. ; , s. 356-359
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Konferensbidrag (refereegranskat)abstract
- In this work we present the development of a disposable liquid handling lab-on-a-chip (LOC) system with embedded actuators for applications in analytical chemistry. The proposed nanoliter liquid handling is based on a temperature sensitive silicone elastomer composite, consisting of PDMS and expandable microspheres. In our LOC system, we integrate active dosing, transportation and merging of nanoliter liquid volumes. The disposable successfully demonstrates precise sample volume control with smart microfluidic manipulation and on-chip active microfluidic components. It is entirely fabricated from low-cost materials using wafer-level processing. Moreover, a biochemical luminescent reaction was successfully conducted to exemplify its applicability as an LOC.
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| 5. |
- Samel, Björn, et al.
(författare)
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Single-use microfluidic pumps and valves based on a thermally responsive PDMS composite : Technical Digest
- 2005
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Ingår i: MEMS 2005 Miami. - : IEEE. - 0780387325 ; , s. 690-693
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Konferensbidrag (refereegranskat)abstract
- In this work we present active microfluidic liquid handling integrated on-chip with no need for external actuators. The concept is based on a temperature sensitive silicone elastomer composite, consisting of PDMS and expandable microspheres. We successfully fabricated single-use microfluidic pumps and displaced liquids in the range of nanoliters even against counter pressures up to 100kPa. Moreover, liquid flow in a microchannel was entirely blocked by means of integrated valves. The valves could withstand pressures up to 140kPa. The devices were fabricated entirely from low cost materials and allow wafer-level processing to be used.
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| 6. |
- Stemme, Göran, 1958-, et al.
(författare)
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Microfluidic system
- 2005
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Patent (populärvet., debatt m.m.)
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