| 1. |
- Johnsson, Folke, et al.
(författare)
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On-demand treatment in patients with oesophagitis and reflux symptoms : Comparison of lansoprazole and omeprazole
- 2002
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Ingår i: Scandinavian Journal of Gastroenterology. - : Informa UK Limited. - 0036-5521 .- 1502-7708. ; 37:6, s. 642-647
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Tidskriftsartikel (refereegranskat)abstract
- Background: There are few data on how patients on maintenance treatment of reflux oesophagitis take their medication. This study was designed to investigate the dosing patterns of patients on on-demand treatment and to compare lansoprazole with omeprazole in this regard. Methods: Patients with reflux oesophagitis, initially treated until absence of symptoms, took capsules of either lansoprazole (30 mg) or omeprazole (20 mg) for 6 months, they were instructed to take the medication only when reflux symptoms occurred. In order to document dosing patterns, the medication was dispensed in bottles supplied with a Medication Event Monitoring System recording date and time the bottles were opened. There were regular follow-up visits with assessment of symptoms. Results: Three-hundred patients were eligible for analysis according to 'all patients treated'. A dosing pattern was found of an increased intake mornings and evenings and constant intervals between intakes. Although there was no correlation between oesophagitis grade or initial symptoms and the amount of medication consumed, the patients had significantly fewer reflux symptoms the more medication they consumed. There was no difference in the number of capsules consumed between the lansoprazole (0.73 capsules/day) and omeprazole groups (0.71 capsules/day). Nor was there any difference between the groups in reflux symptoms during the course of the study. Conclusion: Despite rigorous instructions to take medication on demand, the results suggest that it is patient habits more so than symptoms that determine the frequency and interval of medication intake. Symptoms are not therefore decisive for the amount of medication consumed.
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| 2. |
- Bergenius, S., et al.
(författare)
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Proton irradiation response of CsI(Tl) crystals for the GLAST calorimeter
- 2003
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Ingår i: 2003 IEEE Nuclear Science Symposium Conference Record. - : IEEE Press. - 0780382579 ; , s. 1096-1099
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Konferensbidrag (refereegranskat)abstract
- The electromagnetic calorimeter of the Gamma-Ray Large Area Space Telescope (GLAST) consists of 16 towers of CsI(Tl) crystals. Each tower contains 8 layers of crystals (each 326.0x26.7x19.9 mm3) arranged in a hodoscopic fashion. The crystals are read out at both ends with photodiodes. Crystals produced by Amcrys-H (Ukraine) are used. A full size crystal was irradiated with a 180 MeV proton beam and the radiation induced attenuation was measured. The induced radioactivity of the crystal was also studied. In this paper we will discuss the damage due to proton irradiation and compare this with the expected in-orbit background flux.
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| 3. |
- Bergenius, S., et al.
(författare)
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Radiation hardness tests of CSI(Tl) crystals for the GLAST electromagnetic calorimeter
- 2003
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Ingår i: Proceedings of 28th International Cosmic Ray Conference. ; , s. 2787-2790
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Konferensbidrag (refereegranskat)abstract
- The electromagnetic calorimeter of the Gamma ray Large Area Space Telescope(GLAST) consists of 16 towers of CsI(Tl) crystals. Each tower contains 8layers of crystals (each 326.0×26.7×19.9 mm3) arranged in a hodoscopic fashion.The crystals are read out at both ends with PIN photodiodes. Crystals producedby Amcrys-H (Ukraine) are used. As a part of the quality control procedureduring crystal production, samples from the uncut boules are systematically irradiatedwith gamma rays from a 60Co source. Studies have also been carried outto verify the correspondence between the post-irradiation properties of the boulesamples and the full size crystals which are subsequently cut from the boule. Thefull size crystals have also been irradiated with a 180 MeV proton beam and theradiation induced attenuation measured.
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| 4. |
- Gydesen, S, et al.
(författare)
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Chromosome 3 linked frontotemporal dementia (FTD-3)
- 2002
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Ingår i: Neurology. - 1526-632X. ; 59:10, s. 1585-1594
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Tidskriftsartikel (refereegranskat)abstract
- Background: The authors have identified and studied a large kindred in which frontotemporal dementia (FTD) is inherited as an autosomal dominant trait. The trait has been mapped to the pericentromeric region of chromosome 3. Methods: The authors report on the clinical, neuroimaging, neuropsychological, and pathologic features in this unique pedigree collected during 17 years of study. Results: Twenty-two individuals in three generations have been affected; the age at onset varies between 46 and 65 years. The disease presents with a predominantly frontal lobe syndrome but there is also evidence for temporal and dominant parietal lobe dysfunction. Late in the illness individuals develop a florid motor syndrome with pyramidal and extrapyramidal features. Structural imaging reveals generalized cerebral atrophy; H-2 O-15-PET scanning in two individuals relatively early and late in the disease shows a striking global reduction in cerebral blood flow affecting all lobes. On macroscopic pathologic examination, there is generalized cerebral atrophy affecting the frontal lobes preferentially. Microscopically, there is neuronal loss and gliosis without specific histopathologic features. Conclusions: FTD-3 shares clinical and pathologic features with other forms of FTD and fulfills international consensus criteria for FTD. There is involvement of the parietal lobes clinically, radiologically, and pathologically in FTD-3 in contrast to some forms of FTD. This more diffuse involvement of the cerebral cortex leads to a distinctive, global pattern of reduced blood flow on PET scanning.
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