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1.	Porkka, Kimmo, et al. (author) Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia 2008 In: Blood. - : American Society of Hematology. - 0006-4971 .- 1528-0020. ; 112:4, s. 1005-12 Journal article (peer-reviewed)abstract Although imatinib, a BCR-ABL tyrosine kinase inhibitor, is used to treat acute Philadelphia chromosome-positive (Ph(+)) leukemia, it does not prevent central nervous system (CNS) relapses resulting from poor drug penetration through the blood-brain barrier. Imatinib and dasa-tinib (a dual-specific SRC/BCR-ABL kinase inhibitor) were compared in a preclinical mouse model of intracranial Ph(+) leukemia. Clinical dasatinib treatment in patients with CNS Ph(+) leukemia was assessed. In preclinical studies, dasatinib increased survival, whereas imatinib failed to inhibit intracranial tumor growth. Stabilization and regression of CNS disease were achieved with continued dasa-tinib administration. The drug also demonstrated substantial activity in 11 adult and pediatric patients with CNS Ph(+) leukemia. Eleven evaluable patients had clinically significant, long-lasting responses, which were complete in 7 patients. In 3 additional patients, isolated CNS relapse occurred during dasatinib therapy; and in 2 of them, it was caused by expansion of a BCR-ABL-mutated dasatinib-resistant clone, implying selection pressure exerted by the compound in the CNS. Dasatinib has promising therapeutic potential in managing intracranial leukemic disease and substantial clinical activity in patients who experience CNS relapse while on imatinib therapy. This study is registered at ClinicalTrials.gov as CA180006 (#NCT00108719) and CA180015 (#NCT00110097).
2.	Simonsson, Bengt, et al. (author) A Randomized Phase II Study Comparing Imatinib and the Combination of Imatinib and Pegylated Interferon Alpha-2b in Newly Diagnosed Non-High Risk Chronic Myeloid Leukemia (CML) Patients in Complete Hematological Remission After Imatinib Induction Therapy. in BLOOD, vol 114, issue 22, pp 1269-1270 2009 In: BLOOD. - : American Society of Hematology. ; , s. 1269-1270 Conference paper (peer-reviewed)abstract n/a

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Type of publication: conference paper (1); journal article (1)

Type of content: peer-reviewed (2)

Author/Editor: Porkka, Kimmo (2); Hjorth-Hansen, Henri ... (2); Mustjoki, Satu (2); Koskenvesa, Perttu (2); Gruber, Franz (2); Höglund, Martin (1); show more...; Malm, Claes (1); Simonsson, Bengt (1); Elonen, Erkki (1); Ehrencrona, Hans (1); Dombret, Herve (1); Kairisto, Veli (1); Nagler, Arnon (1); Lanng Nielsen, Johan (1); Weiss-Bjerrum, Ole (1); Zwaan, C Michel (1); Olsson, Karin (1); Knutsen, Håvar (1); Lindblom, Anders (1); Stentoft, Jesper (1); Myhr-Eriksson, Krist ... (1); Sjalander, Anders (1); Flogegard, Max (1); Wild, Robert (1); Remes, Kari (1); Brethon, Benoit (1); Markevarn, Berit (1); Gedde-Dahl, Tobias (1); Lundan, Tuija (1); Bjoreman, Mats (1); Rasanen, Anu (1); Paquette, Ron (1); Sinisalo, Marjatta (1); Rimpiläinen, Johanna (1); Smykla, Richard (1); Luo, Roger (1); Arnan, Montserrat (1); Eccersley, Lydia (1); Klamova, Hana (1); Parikh, Suhag (1); Raffoux, Emmanuel (1); Brito-Babapulle, Fin ... (1); Duarte, Rafael F. (1); Lee, Francis Y. F. (1); Almqvist, Anders (1); Hallman, Heikki (1); Sippola, Risto (1); Stromberg, Ulla (1); show less...

University: Uppsala University (1); Linköping University (1)

Language: English (2)

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