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White to beige conv...
White to beige conversion in PDE3B KO adipose tissue through activation of AMPK signaling and mitochondrial function
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- Chung, Youn Wook (författare)
- Yonsei University,National Heart Lung and Blood Institute
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- Ahmad, Faiyaz (författare)
- National Heart Lung and Blood Institute
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- Tang, Yan (författare)
- National Heart Lung and Blood Institute
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- Hockman, Steven C. (författare)
- National Heart Lung and Blood Institute
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- Kee, Hyun Jung (författare)
- Yonsei University
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- Berger, Karin (författare)
- Lund University,Lunds universitet,Molekylär nutrition,Forskargrupper vid Lunds universitet,Molecular Nutrition,Lund University Research Groups
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- Guirguis, Emilia (författare)
- National Heart Lung and Blood Institute
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- Choi, Young Hun (författare)
- National Heart Lung and Blood Institute
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- Schimel, Dan M. (författare)
- Functional Magnetic Resonance Imaging Core Facility
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- Aponte, Angel M. (författare)
- National Heart Lung and Blood Institute
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- Park, Sunhee (författare)
- National Heart Lung and Blood Institute
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- Degerman, Eva (författare)
- Lund University,Lunds universitet,Signaltransduktionsforskning,Forskargrupper vid Lunds universitet,Insulin Signal Transduction,Lund University Research Groups
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- Manganiello, Vincent C (författare)
- National Heart Lung and Blood Institute
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(creator_code:org_t)
- 2017-01-13
- 2017
- Engelska.
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Ingår i: Scientific Reports. - : Springer Science and Business Media LLC. - 2045-2322. ; 7
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.nature.c...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tissue (WAT) reflects a potential strategy in the fight against obesity and diabetes. Cyclic adenosine monophosphate (cAMP) is very important in the development of the beige phenotype and activation of its thermogenic program. To study effects of cyclic nucleotides on energy homeostatic mechanisms, mice were generated by targeted inactivation of cyclic nucleotide phosphodiesterase 3b (Pde3b) gene, which encodes PDE3B, an enzyme that catalyzes hydrolysis of cAMP and cGMP and is highly expressed in tissues that regulate energy homeostasis, including adipose tissue, liver, and pancreas. In epididymal white adipose tissue (eWAT) of PDE3B KO mice on a SvJ129 background, cAMP/protein kinase A (PKA) and AMP-activated protein kinase (AMPK) signaling pathways are activated, resulting in "browning" phenotype, with a smaller increases in body weight under high-fat diet, smaller fat deposits, increased β-oxidation of fatty acids (FAO) and oxygen consumption. Results reported here suggest that PDE3B and/or its downstream signaling partners might be important regulators of energy metabolism in adipose tissue, and potential therapeutic targets for treating obesity, diabetes and their associated metabolic disorders.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- Av författaren/redakt...
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Chung, Youn Wook
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Ahmad, Faiyaz
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Tang, Yan
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Hockman, Steven ...
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Kee, Hyun Jung
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Berger, Karin
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visa fler...
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Guirguis, Emilia
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Choi, Young Hun
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Schimel, Dan M.
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Aponte, Angel M.
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Park, Sunhee
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Degerman, Eva
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Manganiello, Vin ...
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visa färre...
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Lunds universitet