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| 2. |
- Schon, K., et al.
(författare)
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Intercomparison on PD calibrators and PD instruments
- 1999
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Ingår i: IEE Conference Publication. - : Institute of Electrical and Electronics Engineers (IEEE). - 0852967195 ; , s. 1.5.S1-1.8.S1
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Konferensbidrag (refereegranskat)abstract
- Within the framework of a European project, two partial discharge calibrators were circulated to thirteen laboratories for an intercomparison of impulse charge measurements in the range between 1 pC and 500 pC. The deviations of the charge values q reported by the laboratories were, with a very few exceptions, within ±(0.1 pC+0.03·q). Furthermore, the characteristics of several partial discharge measuring instruments were investigated. The indication of some of the instruments showed deviations of more than ten percent from the correct values.
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| 3. |
- Biver, N, et al.
(författare)
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Long-term evolution of the outgassing of comet Hale-Bopp from radio observations
- 1997
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Ingår i: EARTH MOON AND PLANETS. - : KLUWER ACADEMIC PUBL. - 0167-9295. ; 78:1-3, s. 5-11
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Tidskriftsartikel (refereegranskat)abstract
- C/1995 O1 (Hale-Bopp) has been observed on a regular basis since August 1995 at millimetre and submillimetre wavelengths using IRAM, JCMT, CSO and SEST radio telescopes. The production rates of eight molecular species (CO, HCN, CH3OH, H2CO, H2S, CS, CH3CN
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| 4. |
- Cederbrant, Karin, et al.
(författare)
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In vitro Lymphoproliferative Assays with HgCl2 Cannot Identify Patients with Systemic Symptoms Attributed to Dental Amalgam
- 1999
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Ingår i: Journal of Dental Research. - : SAGE Publications. - 0022-0345 .- 1544-0591. ; 78:8, s. 1450-1458
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Tidskriftsartikel (refereegranskat)abstract
- Dental amalgam is suspected, by some exposed individuals, to cause various systemic psychological, sensory, and neurological symptoms. Since not all amalgam-bearers experience such reactions, an individual characteristic—for example, a susceptible immune system—might explain these conditions. In vitro lymphocyte proliferation is a valuable tool in the diagnosis of allergy. With HgCl2 as the antigen, however, the test is hampered, because Hg2+ can cause unspecific lymphocyte proliferation, optimal at 1.4 to 9.5 μg HgCl2/mL. Recently, the use of suboptimal HgCl2 concentrations (≤ 0.5 μg/mL) has been suggested to circumvent these problems. The main aim of this study was to investigate whether patients with systemic symptoms alleged to result from the presence of dental amalgam differ from healthy controls, with reference to in vitro lymphoproliferative responses to HgCl2 ≤ 0.5 μg/mL. Three different test protocols—lymphocyte transformation test (LTT) in micro- and macro-cultures, and the memory lymphocyte immunostimulation assay (MELISA®)—were used. Other immune parameters—such as a standard patch test for dental materials, the number of T- and B-lymphocytes, monocytes, granulocytes, and NK cells in peripheral blood, allergic symptoms, and predisposition-were also investigated. Twenty-three amalgam patients, 30 healthy blood donors with amalgam, ten healthy subjects without amalgam, and nine patients with oral lichen planus (OLP) adjacent to dental amalgam and a positive patch test to Hg0 were tested. None of the investigated immune parameters revealed any significant differences between amalgam patients and controls. The sensitivity of in vitro lymphocyte proliferation ranged from 33 to 67%, with the OLP patients as a positive control group, and the specificity from 0 to 70% for healthy controls with a negative patch test to Hg°. Thus, despite the use of HgCl2 ≤ 0.5 μg/mL, a high frequency of positive results was obtained among healthy subjects with or without dental amalgam. Consequently, in vitro lymphocyte proliferation with HgCl2 cannot be used as an objective marker for mercury allergy in dental amalgam-bearers.
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| 5. |
- Gerdtham, Ulf G., et al.
(författare)
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The effect of changes in treatment patterns on drug expenditure
- 1998
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Ingår i: PharmacoEconomics. - : Springer Nature. - 1179-2027 .- 1170-7690. ; 13:1 PART II, s. 127-134
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Tidskriftsartikel (refereegranskat)abstract
- This paper investigates the effects of changes in drug therapy on drug expenditure in Sweden between 1990 and 1995. Analyses have been carried out for both the aggregate drug expenditure and for drug expenditure according to the main groups of the Anatomical Therapeutic Chemical (ATC) classification system. Changes in expenditure can be divided into 3 components: the price of drugs, the quantity of drugs consumed and a residual. The size of the residual is a measure of the effect of changes in drug treatment patterns on drug expenditure. The aggregate real drug expenditure increased by 50% between 1990 and 1995. The relative retail price index of drugs decreased by 9% and the quantity index measured in terms of defined daily doses increased by 27%. The remaining residual increased by 30%. This implies that, if the residual had been unchanged during the study period, the aggregate expenditure would have increased by only 15%. The results also show that the size of the residual varies substantially across different ATC groups. The increase in the residual was largest for drugs that affect the nervous system (ATC group N); the residual increased by 86%. From the observed changes in residual values, it can be concluded that the underlying factor responsible for the increase in drug expenditure in Sweden is changes in drug therapy from less expensive to more expensive drugs.
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| 8. |
- Gunnarsson, Tove, et al.
(författare)
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Cholecystokinin peptides in cerebrospinal fluid : a study in healthy male subjects
- 1997
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Ingår i: Regulatory Peptides. - 0167-0115 .- 1873-1686. ; 68:1, s. 57-61
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Tidskriftsartikel (refereegranskat)abstract
- The clinical reliability of measuring cholecystokinin (CCK) peptides in the cerebrospinal fluid (CSF) has not been fully elucidated. Therefore, we have assayed CCK-8S and CCK-4 in CSF obtained from 14 healthy male subjects, lumbar-punctured at the L4–5 level following a strictly standardised procedure. CSF concentrations of free CCK-8S and free CCK-4 were used as dependent variables while age, height, body weight, atmospheric pressure and some other factors served as independent variables. It was shown that the CCK-8S ratio between the second (7–12 ml) and first (0–6 ml) CSF fractions, correlated significantly with the atmospheric pressure at the time of puncture. Neither CCK-8S nor CCK-4 displayed concentration gradients in CSF. The CCK-4 levels, expressed as pmol l−1 in the total amount of CSF were found to be positively correlated with the neuraxis distance in the lying position and negatively with the neuraxis distance in the sitting position. Furthermore, CCK-4, expressed as pmol l−1 per min of tapping-time (pmol l−1 min−1), showed a negative correlation with storage time, presumably mirroring a proteolytic process. CCK-8S and CCK-4 intercorrelated positively independently of whether expressed as pmol l−1 or pmol l−1 min−1. In conclusion, the results of this exploratory study indicate that the neuraxis distance (in the sitting and lying positions) and storage-time have to be accounted for when interpreting data on CSF levels of CCK-4. Attention has to be paid to the potential influence of atmospheric pressure on the concentration ratio of CCK-8S.
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