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- Stålberg, Peter, et al.
(författare)
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Suppression of the neoplastic phenotype by transfection of phospholipase C3 to neuroendocrine tumor cells
- 1999
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Ingår i: FEBS Letters. - 0014-5793 .- 1873-3468. ; 450:3, s. 210-216
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Tidskriftsartikel (refereegranskat)abstract
- The expression of phospholipase C beta 3 (PLCB3) is low or absent in several neuroendocrine neoplasias. To investigate the role of PLCB3 in the neuroendocrine tumorigenesis, we transfected a PLCB3 construct to three neuroendocrine tumor cell lines with a low PLCB3 expression. The growth rate and tumorigenicity were assessed in vitro by [3H]thymidine incorporation and cell counting, in vivo, by xenografting to nude mice. In vitro, PLCB3 expressing clones showed a significant growth inhibition. The tumor weight was reduced for one of the two xenografted PLCB3-transfected cell lines and in both, a reduced number of proliferating (Ki-67 positive) cells was observed. This study implies an essential role for PLCB3 in the neuroendocrine tumorigenesis.
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