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Träfflista för sökning "WFRF:(Gustavsson P) srt2:(2015-2019)"

Search: WFRF:(Gustavsson P) > (2015-2019)

  • Result 1-10 of 75
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  • Semb, G, et al. (author)
  • Erratum
  • 2017
  • In: Journal of plastic surgery and hand surgery. - 2000-6764. ; 51:2, s. 158-158
  • Journal article (peer-reviewed)
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  • Danenberg, P. V., et al. (author)
  • Folates as adjuvants to anticancer agents: Chemical rationale and mechanism of action
  • 2016
  • In: Critical Reviews in Oncology Hematology. - : Elsevier BV. - 1040-8428. ; 106, s. 118-131
  • Journal article (peer-reviewed)abstract
    • Folates have been used with cytotoxic agents for decades and today they are used in hundreds of thousands of patients annually. Folate metabolism is complex. In the treatment of cancer with 5-fluorouracil, the administration of folates mechanistically leads to the formation of [6R]-5,10-methylene-tetrahydrofolate, and the increased concentration of this molecule leads to stabilization of the ternary complex comprising thymidylate synthase, 2'-deoxy-uridine-5'-monophosphate, and [6R]-5,10-methylene-tetrahydrofolate.The latter is the only natural folate that can bind directly in the ternary complex, with other folates requiring metabolic activation. Modulation of thymidylate synthase activity became central in the study of folate/cytotoxic combinations and, despite wide use, research into the folate component was neglected, leaving important questions unanswered. This article revisits the mechanisms of action of folates and evaluates commercially available folate derivatives in the light of current research. Better genomic insight and availability of new analytical techniques and stable folate compounds may open new avenues of research and therapy, ultimately bringing increased clinical benefit to patients. (C) 2016 The Authors. Published by Elsevier Ireland Ltd.
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  • Result 1-10 of 75
Type of publication
journal article (58)
conference paper (16)
reports (1)
Type of content
peer-reviewed (58)
other academic/artistic (17)
Author/Editor
Gustavsson, P (33)
Straif, K (8)
Bruning, T (8)
Schuz, J (8)
Kromhout, H (7)
Foretova, L (7)
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Janout, V (7)
Lissowska, J (7)
Stucker, I (7)
Ahrens, W (7)
Gustavsson, A. (7)
Pohlabeln, H. (7)
Jockel, KH (7)
Landi, MT (7)
Kendzia, B (7)
Bruske, I (7)
Wichmann, HE (7)
Szeszenia-Dabrowska, ... (7)
Rudnai, P (7)
Fabianova, E (7)
Tardon, A (7)
Dumitru, RS (7)
Bencko, V (7)
Siemiatycki, J (7)
McLaughlin, J (7)
Demers, P (7)
Guida, F (7)
Boffetta, P (6)
Merletti, F (6)
Richiardi, L (6)
Lindstrand, A (6)
Zaridze, D (6)
Vermeulen, R. (6)
Caporaso, N (6)
Nilsson, D (5)
Nordenskjold, M (5)
Behrens, T (5)
Plato, N (5)
Peters, S. (5)
Simonato, L (5)
Forastiere, F (4)
Krantz, Philip, 1984 (4)
Olsson, A (4)
Nordgren, A (4)
Pearce, N (4)
Mirabelli, D (4)
Field, J (4)
Parent, ME (4)
Consonni, D (4)
't Mannetje, A (4)
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University
Karolinska Institutet (49)
Chalmers University of Technology (10)
University of Gothenburg (8)
Royal Institute of Technology (4)
Uppsala University (4)
Lund University (4)
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Umeå University (3)
Linköping University (3)
Swedish University of Agricultural Sciences (3)
Stockholm University (2)
Örebro University (1)
Stockholm School of Economics (1)
Linnaeus University (1)
Karlstad University (1)
Blekinge Institute of Technology (1)
Marie Cederschiöld högskola (1)
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Language
English (75)
Research subject (UKÄ/SCB)
Medical and Health Sciences (15)
Natural sciences (14)
Engineering and Technology (13)
Agricultural Sciences (1)
Social Sciences (1)
Humanities (1)

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