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- Nässla, Hans, 1956-
(författare)
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Intra-Family Information Flow and Prospects for Communication Systems
- 2004
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Licentiatavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Today, information and communication technology is not only for professional use, but also for private tasks. In this thesis, the use of such technology for managing family information flow is investigated. Busy family life today, with school, work and leisure activites, makes coordination and synchronisation a burden. In what way cell-phones and Internet provides a support for those tasks is investigated, together with proposals for future technology.The problem with coordination and synchronisation were found to be managed by a bulletin board placed at a central point at home. Besides the bulletin board, we found that calendars, shopping lists, and to-do lists are important. The families we investigated in field studies were all intensive users of both Internet and cell-phones.Since the bulletin board played such an important role in the family life, we equipped families with cameras to be able to track what happened at those places with help of photo diaries. The field studies revealed that each family had their own unconscious procedure to manage the flow of notes on the bulletin board.With technology, new problem will emerge. We investigated how notes on typical family bulletin boards may be visualised on a computer screen, and compared click-expand, zoom-pan and bifocal interfaces. The click-expand interface was substantially faster for browsing, and also easier to use.An advantage of information and communication technology is that it may provide possibilities for multiple interfaces to information, and not only different terminals but also from different places. At home, a digital refrigerator door or a mobile web tablet; at work or at school, a conventional computer; when on the move, a cell-phone or a PDA. System architecture for these possibilities is presented.
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- Ringdén, Olle, et al.
(författare)
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Transplantation of Autologous and Allogeneic Bone Marrow With Liver From A Cadaveric Donor for Primary Liver Cancer1
- 2000
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Ingår i: Transplantation. - : Ovid Technologies (Wolters Kluwer Health). - 0041-1337 .- 1534-6080. ; 69:10, s. 2043-2048
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- BackgroundIn histocompatibility mismatched experimental animals, a combination of T-cell-depleted autologous and allogeneic marrow may induce mixed chimerism and tolerance. Patients with large primary liver tumors have a poor outcome. We investigated whether it were possible to induce mixed chimerism and obtain an antitumor effect in a patient with a large primary liver cancer after combined liver and bone marrow transplantation (BMT).MethodsA 46-year-old female with a primary non resectable liver cancer received a liver transplant from a cadaveric donor. Subsequently, she was conditioned with 4×2 Gy of total lymphoid irradiation, 120 mg/kg cyclophosphamide, and 7.5 Gy total body irradiation. Twelve days after liver transplantation, she received T-cell-depleted autologous : cadaveric 5/6 antigen HLA-mismatched marrow in a proportion of CD34+ cells of 0.5 : 3.0×106/kg. Chimerism status was determined with polymerase chain reaction amplification of variable number tandem repeats from DNA obtained from CD3+, CD19+, and CD45+ magnetic-bead-separated cells.ResultsThe early posttransplant period was uneventful; liver function was normal and the hematopoietic engraftment of donor and recipient origin was prompt. [alpha]-fetoprotein levels dropped from 440 to 35 µg/l. One month after marrow transplantation, donor T-cells decreased markedly. Monoclonal antibody OKT-3 and 105/kg donor T-cells were given. One month later, the patient developed diarrhea and abdominal pain. A colonoscopy showed moderate gastrointestinal acute graft-versus-host disease and a Cryptosporidium infection. Three months after BMT, she became a complete donor chimera. Chimera cells showed little, if any, reactivity in mixed lymphocyte cultures to recipient and donor cells, but reacted to third party. Five months after BMT, she developed progressive Aspergillus fumigatus pneumonia and died. No tumor was found at the autopsy.ConclusionWe obtained mixed donor-recipient hematopoietic chimerism without severe acute graft-versus-host-disease, after combined T-cell depleted autologous and allogeneic BMT and a transplantation of a liver from an HLA-mismatched cadaveric donor. Additional donor T-cells enhanced donor bone marrow engraftment, but rejected the autograft. On the basis of this first attempt, further clinical studies are warranted.
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