| 1. |
- Bergquist, Jonas, et al.
(författare)
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Mass spectrometry of proteins - Uppsala perspectives on past and present : Paper in honor of Prof. Peter Roepstorff's 65th birthday
- 2007
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Ingår i: International Journal of Mass Spectrometry. - : Elsevier BV. - 1387-3806 .- 1873-2798. ; 268:2-3, s. 73-82
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Tidskriftsartikel (refereegranskat)abstract
- The development of biological mass spectrometry has been rapid in the past three to four decades. In particular, the possibility to detect and identify peptides and proteins from biologically and medically relevant samples has revolutionized life sciences. The development has gone from a stage where the detection of insulin in a mass spectrum was a major event to one in which the recording of mass spectra with more than 104 resolved and calibrating peaks in each spectrum is a routine task.In this paper, the evolution of protein mass spectrometry will be discussed from the Uppsala horizon with special emphasis on the unique coupling between ion induced desorption of biomolecules and ion track physics.
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| 2. |
- Brandt, Anders, et al.
(författare)
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Properties of bone conduction hearing
- 2006
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Ingår i: XXIV International Modal Analysis Conference, St. Louis, Missouri.
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Konferensbidrag (refereegranskat)
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| 3. |
- Brandt, Anders, et al.
(författare)
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Properties of Bone Conduction Hearing
- 2006
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Konferensbidrag (refereegranskat)abstract
- Bone conduction sound, the transmission of sound as vibrations in the skull bone, is used in several areas, forexample for hearing aids, in audiometry, and in communication systems. The bone-anchored hearing aid (BAHA)has been commercially available for many years. This device utilizes titanium screws attached to the skull bonepenetrating the soft tissues thus providing a rigid attachment to the skull bone. Subjects equipped with suchtitanium screws have proven important for investigation of bone conducted sound and in the present paper anoverview of some results from different studies on such patients is given. Included are results from investigationsof resonance frequencies, propagation delays, and transcranial (cross-skull) attenuation.
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| 4. |
- Hanberg, Annika, et al.
(författare)
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Phthalates and their metabolites in human breast milk, blood and urine as measures for monitoring exposure in human risk groups
- 2005
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Rapport (övrigt vetenskapligt/konstnärligt)abstract
- För att undersöka halter av ftalater i svenskar och vilken matris som bäst lämpar sig för hälsorelaterad miljöövervakning har ftalater och ftalatmetaboliter analyserats i en grupp kvinnor som nyligen fött barn. I samband med förlossning på Universitetssjukhuset i Lund tillfrågades förstföderskor om medverkan och 42 kvinnor kom att ingå i studien. När barnet var 2-3 veckor gammalt pumpade mamman ut 50 mL bröstmjölk. Blod- och urinprov togs en vecka senare. Omfattande förändringar av standardmetoder för provtagning av mjölk och blod gjordes för att minimera risken för kontaminering av proverna. För mjölkprovtagningen användes en specialkonstruerad manuell pump av polykarbonat med ftalatfri packning. Blodprov togs med hjälp av endast kanyl och provrör (eftersom propparna i vaccutainrör innehåller ftalater). Proverna förvarades i värmebehandlade glasbehållare och fosforsyra tillsattes för att motverka metabolism av ftalater i mjölk- och blodprover. Analyserna av bröstmjölk visade värden nära eller under detektionsgränsen (LOD) för flertalet ftalater eller deras metaboliter. Även i blod och serum var nivåerna vanligtvis nära eller under LOD. I urin analyserades endast metaboliter och dessa kunde kvantifieras i 53-100 % av proverna. Nivåerna av ftalatmetaboliter i urin hos de svenska kvinnorna var i paritet med nivåerna hos en allmänbefolkning i USA och Tyskland. Några klara korrelationer mellan nivåer i t ex urin och bröstmjölk respektive blod påvisades inte. Resultaten av studien anger att för närvarande är analys av ftalatmetaboliter i urin den mest framkomliga vägen för skattning av ftalatexponering hos människa. Provtagning och analys av mjölk och blod innebar betydligt större svårigheter. Framför allt framstår risken för kontaminering vid provtagning som betydande och en stor del av ftalaterna och dess metaboliter uppvisade låga halter, vid eller under LOD. Dessutom kan ftalater brytas ned i blod och mjölk. I flertalet internationella publicerade studier av ftalatexponering används urinmetabolit-analyser som ett mått på exponering för ftalater. I en nyligen publicerad amerikansk studie av ett 80-tal nyfödda pojkar sågs ett samband mellan kort ano-genitalt avstånd och nivåer av ftalatmetaboliter i urin hos deras mammor under graviditeten. Den amerikanska studien behöver bekräftas, men metaboliterna var desamma som i vår studie och en jämförelse visar att mediannivåerna var lägre för vissa men högre för andra metaboliter. Vår studie indikerar att svenska kvinnor i fertil ålder inte sällan exponeras för ftalater i nivåer som satts i samband med fosterpåverkan.
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| 5. |
- Helldén, Daniel, 1965-
(författare)
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Demokratin utmanas : Almstriden och det politiska etablissemanget
- 2005
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The aim of the thesis is to describe how the political establishment understood the Elm Conflict (Almstriden) in Stockholm in 1971, and the way in which the establishment expressed that understanding when it made sense of the challenge to itself and to how local politics worked. The political establishment is defined as politicians in central positions in Stockholm and at the national level and the editorial pages of the Stockholm newspapers. Three themes are used to describe the construction of the establishment: a) what the cause was for the elm issue having developed the way it did; b) why that which happened was wrong; and c) why it could happen at all in Sweden. The analysed empirical material consists solely of texts and statements produced at the time of the Elm Conflict. The thesis shows that the establishment, examined at close quarters, explained the Elm Conflict as caused by either media behaviour or political inability. The political establishment was in relative agreement on the matter of local democracy: municipal democracy was first and foremost a matter for the parties and politicians. No priority needed to be given to municipal reforms. What was needed was better information about why politicians had taken specific decisions. The Liberal Party leader and newspapers differed in this respect, however, exercising more caution in pointing at more far-reaching proposals for reform. When it came to political methods, Hjalmar Mehr proved to be the person who condemned the events most strongly, and this would seem to stem from his view of democracy. The Social Democratic Party at the national level was of the view that the conflict should be condemned, but had difficulties with the criticism levelled at local democracy. The newspapers and Liberal Party leader went the farthest in their positive statements concerning the method but had difficulties putting this in words. When it came to the causes of the Elm Conflict in a larger context, explanations were sought in a world gone mad, outside forces that wanted to overturn democracy, and politicians who failed to understand people’s concerns in the face of social change. The thesis also touches on why the politicians in Stockholm found themselves involved in the conflict and on the relationship of the Social Democrats to parts of the radicalisation trend of the late 1960s.
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| 6. |
- Håkansson, Anna, 1978, et al.
(författare)
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Cyclooxygenase-2 polymorphisms in Parkinson's disease.
- 2007
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Ingår i: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-4841. ; 144:3, s. 367-9
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Tidskriftsartikel (refereegranskat)abstract
- Accumulating evidence indicate that cyclooxygenase-2 (COX-2) is of pathophysiological importance for the neurodegeneration in Parkinson's disease (PD). For example, in a large epidemiological study, use of NSAIDs was associated with a lower risk of PD. Genetic variants of the COX-2 gene might therefore influence the risk of developing the disease. The genotype distribution of four common single nucleotide polymorphisms (SNPs) in the COX-2 gene (rs689466:A496G, rs20417:G926C, rs5277:G3050C, rs5275:C8473T) was analyzed in PD patients and control subjects in a Swedish population. No differences could be seen between the PD-patient and controls regarding the A496G, G926C, and G3050C SNPs, but the allele frequency of the C8473T SNP was found to differ when male patients were compared to controls (P = 0.007). In females no difference could be seen between PD-patients and controls. In conclusion, the results suggest a possible influence of the COX-2 C8473T SNP in PD, although it only seems to be of importance in men.
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| 7. |
- Håkansson, Anna, 1978, et al.
(författare)
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Interaction of polymorphisms in the genes encoding interleukin-6 and estrogen receptor beta on the susceptibility to Parkinson's disease.
- 2005
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Ingår i: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. - : Wiley. - 1552-4841 .- 1552-485X. ; 133:1, s. 88-92
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Tidskriftsartikel (refereegranskat)abstract
- The multifunctional cytokine interleukin-6 (IL-6) is involved in inflammatory processes in the central nervous system and increased levels of IL-6 have been found in patients with Parkinson's disease (PD). It is known that estrogen inhibits the production of IL-6, via action on estrogen receptors, thereby pointing to an important influence of estrogen on IL-6. In a previous study, we reported an association between a G/A single nucleotide polymorphism (SNP) at position 1730 in the gene coding for estrogen receptor beta (ERbeta) and age of onset of PD. To investigate the influence of a G/C SNP at position 174 in the promoter of the IL-6 gene, and the possible interaction of this SNP and the ERbeta G-1730A SNP on the risk for PD, the G-174C SNP was genotyped, by pyrosequencing, in 258 patients with PD and 308 controls. A significantly elevated frequency of the GG genotype of the IL-6 SNP was found in the patient group and this was most obvious among patients with an early age of onset (
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| 8. |
- Håkansson, Anna, 1978, et al.
(författare)
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Investigation of genes coding for inflammatory components in Parkinson's disease.
- 2005
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Ingår i: Movement disorders : official journal of the Movement Disorder Society. - : Wiley. - 0885-3185 .- 1531-8257. ; 20:5, s. 569-73
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Tidskriftsartikel (refereegranskat)abstract
- Several findings obtained recently indicate that inflammation may contribute to the pathogenesis in Parkinson's disease (PD). Genetic variants of genes coding for components involved in immune reactions in the brain might therefore influence the risk of developing PD or the age of disease onset. Five single nucleotide polymorphisms (SNPs) in the genes coding for interferon-gamma (IFN-gamma; T874A in intron 1), interferon-gamma receptor 2 (IFN-gamma R2; Gln64Arg), interleukin-10 (IL-10; G1082A in the promoter region), platelet-activating factor acetylhydrolase (PAF-AH; Val379Ala), and intercellular adhesion molecule 1 (ICAM-1; Lys469Glu) were genotyped, using pyrosequencing, in 265 patients with PD and 308 controls. None of the investigated SNPs was found to be associated with PD; however, the G1082A polymorphism in the IL-10 gene promoter was found to be related to the age of disease onset. Linear regression showed a significantly earlier onset with more A-alleles (P = 0.0095; after Bonferroni correction, P = 0.048), resulting in a 5-year delayed age of onset of the disease for individuals having two G-alleles compared with individuals having two A-alleles. The results indicate that the IL-10 G1082A SNP could possibly be related to the age of onset of PD.
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| 9. |
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| 10. |
- Håkansson, Bo, et al.
(författare)
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A novel bone conduction implant (BCI)
- 2009
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Ingår i: 2<sup>nd</sup> Int Symposium on Bone Conduction Hearing – Craniofacial Osseointegration, Göteborg, Sweden.
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Konferensbidrag (refereegranskat)
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