| 1. |
- Carlson, Marie, et al.
(författare)
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Degranulation of eosinophils from pollen-atopic patients with asthma is increased during pollen season
- 1992
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Ingår i: Journal of Allergy and Clinical Immunology. - 0091-6749 .- 1097-6825. ; 89:1 Pt 1, s. 131-139
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Tidskriftsartikel (refereegranskat)abstract
- The secretion of granule proteins from eosinophils and neutrophils was studied in isolated cells, obtained from 11 pollen-atopic patients with asthma, twice during and twice outside pollen season. Granulocytes were stimulated with serum-opsonized Sephadex particles, and the released amount of eosinophil cationic protein (ECP), eosinophil protein X (EPX), and myeloperoxidase (MPO) were measured by means of specific radioimmunoassay (RIA). Eosinophils from the pollen-atopic patients obtained during pollen season released significantly more (p less than 0.02) ECP and EPX than cells from the same patients obtained before pollen season. The released amount of ECP and EPX was correlated (r = 0.54; p less than 0.003) to the total pollen count. The release of MPO from neutrophils was only raised (p less than 0.01) at the end of the pollen season. Serum concentrations of ECP and EPX and blood eosinophil counts were significantly raised (p less than 0.002, p less than 0.001, and p less than 0.009, respectively) before pollen season and increased further at the end of the pollen season. There were no changes in lung function during pollen season and consequently no discernible relationships to eosinophil and neutrophil degranulation. We conclude that eosinophils and, to some extent, neutrophils from birch pollen-atopic subjects have an increased propensity to secrete their granule proteins during a pollen season. We suggest that these cells have been primed as a consequence of allergen exposure.
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| 2. |
- Carlson, Marie, et al.
(författare)
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Secretion of granule proteins from eosinophils and neutrophils is increased in asthma
- 1991
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Ingår i: Journal of Allergy and Clinical Immunology. - : Elsevier BV. - 0091-6749 .- 1097-6825. ; 87:1 Pt 1, s. 27-33
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Tidskriftsartikel (refereegranskat)abstract
- The activity of eosinophil and neutrophil granulocytes with respect to secretion of granule proteins was studied in 30 patients with asthma and with varying severity of their disease. Granulocytes were stimulated with serum-opsonized Sephadex particles, and the released amount of eosinophil cationic protein (ECP), eosinophil protein X (EPX), and myeloperoxidase was measured by means of specific radioimmunoassays. Eosinophils from patients with asthma released significantly more (p less than 0.001) ECP and EPX after 20 minutes of incubation than cells from control subjects without asthma. The release of myeloperoxidase from neutrophils was also somewhat higher (p less than 0.03). The serum concentrations of ECP and EPX were also significantly increased (p less than 0.001) in the group with asthma. No significant relationships were found between clinical variables and the secretory activity of either eosinophils or neutrophils. We conclude that eosinophils and, to some extent, neutrophils from subjects with asthma have an increased propensity to release their granule proteins, which we suggest is a consequence of priming of these cells.
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| 3. |
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| 4. |
- Håkansson, Per, et al.
(författare)
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Strategic alliances in global biotechnology — a network approach
- 1993
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Ingår i: International Business Review. - : Elsevier Inc.. - 1873-6149 .- 0969-5931. ; 2:1, s. 65-82
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Tidskriftsartikel (refereegranskat)abstract
- Strategic alliances, as a means to acquire and co-ordinate resources for technological development, market access and manufacturing efficiency have, during the last years, captured increasing attention. Presumably driven by the globalization of markets and technological development, alliances are increasingly being used as strategic tools for corporate survival and growth, shaping the present and future structure of industries. The establishment of strategic alliances is a characteristic shared by many industries; such as the aircraft, automobile, telecommunications and computer industries, to mention but a few. The issues are if these predominantly hidden industrial structures can be exposed and if we can identify factors determining these structures.
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