| 1. |
- Challis, Pontus, et al.
(författare)
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Association of Adherence to Surfactant Best Practice Uses with Clinical Outcomes among Neonates in Sweden
- 2021
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Ingår i: JAMA Network Open. - : American Medical Association (AMA). - 2574-3805. ; 4:5
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Tidskriftsartikel (refereegranskat)abstract
- Importance: While surfactant therapy for respiratory distress syndrome (RDS) in preterm infants has been evaluated in clinical trials, less is known about how surfactant is used outside such a framework.Objective: To evaluate registered use, off-label use, and omissions of surfactant treatment by gestational age (GA) and associations with outcomes, mainly among very preterm infants (GA <32 weeks).Design, Setting, and Participants: This population-based cohort study used registry data for 97377 infants born in Sweden between 2009 and 2018. Infants did not have malformations and were admitted for neonatal care. Data analysis was conducted from June 2019 to June 2020.Exposures: Timing and number of surfactant administrations, off-label use, and omission of use. Registered use was defined by drug label (1-3 administrations for RDS). Omissions were defined as surfactant not administered despite mechanical ventilation for RDS.Main Outcome and Measures: In-hospital survival, pneumothorax, intraventricular hemorrhage grade 3 to 4, duration of mechanical ventilation, use of postnatal systemic corticosteroids for lung disease, treatment with supplemental oxygen at 28 days' postnatal age and at 36 weeks' postmenstrual age. Odds ratios (ORs) were calculated and adjusted for any prenatal corticosteroid treatment, cesarean delivery, GA, infant sex, Apgar score at 10 minutes, and birth weight z score of less than -2.Results: In total, 7980 surfactant administrations were given to 5209 infants (2233 [42.9%] girls; 2976 [57.1%] boys): 629 (12.1%) born at full term, 691 (13.3%) at 32 to 36 weeks' GA, 1544 (29.6%) at 28 to 31 weeks' GA, and 2345 (45.0%) at less than 28 weeks' GA. Overall, 977 infants (18.8%) received off-label use. In 1364 of 3508 infants (38.9%) with GA of 22 to 31 weeks, the first administration of surfactant was given more than 2 hours after birth, and this was associated with higher odds of pneumothorax (adjusted OR [aOR], 2.59; 95% CI, 1.76-3.83), intraventricular hemorrhage grades 3 to 4 (aOR, 1.71; 95% CI, 1.23-2.39), receipt of postnatal corticosteroids (aOR, 1.57; 95% CI, 1.22-2.03), and longer duration of assisted ventilation (aOR, 1.34; 95% CI, 1.04-1.72) but also higher survival (aOR, 1.45; 95% CI, 1.10-1.91) than among infants treated within 2 hours of birth. In 146 infants (2.8%), the recommended maximum of 3 surfactant administrations was exceeded but without associated improvements in outcome. Omission of surfactant treatment occurred in 203 of 3551 infants (5.7%) who were receiving mechanical ventilation and was associated with lower survival (aOR, 0.49; 95% CI, 0.30-0.82). In full-term infants, 336 (53.4%) of those receiving surfactant had a diagnosis of meconium aspiration syndrome. Surfactant for meconium aspiration was not associated with improved neonatal outcomes.Conclusions and Relevance: In this study, adherence to best practices and labels for surfactant use in newborn infants varied, with important clinical implications for neonatal outcomes.
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| 2. |
- Chang Rundgren, Shu-Nu, 1975-, et al.
(författare)
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Educational Research in Citizenship Competences
- 2022
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Ingår i: The Department of Education at Stockholm University. - Stockholm : Bokförlaget Atlas. - 9789174450385 ; , s. 158-177
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Bokkapitel (refereegranskat)
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| 3. |
- Dahlbeck, Per, et al.
(författare)
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Hållbar utbildning för hållbar utveckling : i förskola och skola
- 2021
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- En berörande och utmanande undervisning är en förutsättning för ett hållbart lärande för en hållbar utveckling. Utgångspunkten i den här boken är att involvera barn och unga i dagens komplexa och svårlösta utmaningar som vi alla står inför för att nå målen i Agenda 2030. När barn blir delaktiga och deras röster tas på allvar utvecklar de förmågor och förhållningssätt för att vara aktiva demokratiska medborgare här och nu och i framtiden. Den här boken ger inga recept för hur denna undervisning ska ske, men väl teorier och praktiska exempel från förskola och skola som kan inspirera den egna pedagogiska praktiken. Hållbar utbildning för hållbar utveckling lämpar sig därför särskilt väl som inspiration till egna samtal och diskussioner samt utveckling av den egna praktiken för pedagoger i förskolor och skolor som övergripande och tematiskt vill arbeta med hållbar utveckling i vid mening.Bokens innehåll kan med fördel fungera som inspiration även för blivande förskollärare och grundskollärare, speciellt för lärare för grundskolans yngre år.
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| 4. |
- Dahlin, Mats, 1975-, et al.
(författare)
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Internet-based self-help using automatic messages and support on demand for generalized anxiety disorder : an open pilot study
- 2020
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Ingår i: Digital Psychiatry. - : Taylor & Francis. - 2575-517X. ; 3:1, s. 12-19
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Tidskriftsartikel (refereegranskat)abstract
- Generalized anxiety disorder (GAD) is a disabling and often chronic condition. Internet-based treatments for GAD have been shown to be effective, but many studies include weekly contact with a therapist with the aim to increase adherence and clinical outcomes. The current study evaluated a less therapist-intensive alternative: support on demand and automatic messages. Thirty-three participants with GAD went through a self-help program targeting excessive worry. Treatment lasted 9 weeks and consisted of seven modules. Participants received short messages with reminders and encouragement. Therapist support was given when asked for. The intervention led to significant and large within-group effects on the primary outcome, Penn State Worry Questionnaire (PSWQ; Cohen’s d = 1.17), as well as on secondary outcomes such as Generalized Anxiety Disorder Questionnaire-IV (GAD-Q-IV; Cohen’s d = 2.71) and Patient Health Questionaire-9 (PHQ-9; Cohen’s d = 1.05). The exception was a small effect on quality of life (d = −0.34). Twenty-four (74.9%) were satisfied with the treatment and one dropped out. Therapist support was used by 65.6%. Limitations include lack of control condition and a small sample. While preliminary, the findings suggest that self-guided internet interventions can work and be acceptable when automated messages and support on demand is provided.
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| 5. |
- Dixon-Suen, Suzanne C, et al.
(författare)
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Physical activity, sedentary time and breast cancer risk : a Mendelian randomisation study
- 2022
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Ingår i: British Journal of Sports Medicine. - : BMJ Publishing Group Ltd. - 0306-3674 .- 1473-0480. ; 56:20, s. 1157-1170
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVES: Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast cancer risk overall, pre/post-menopause, and by case-groups defined by tumour characteristics.METHODS: We performed two-sample inverse-variance-weighted MR using individual-level Breast Cancer Association Consortium case-control data from 130 957 European-ancestry women (69 838 invasive cases), and published UK Biobank data (n=91 105-377 234). Genetic instruments were single nucleotide polymorphisms (SNPs) associated in UK Biobank with wrist-worn accelerometer-measured overall physical activity (nsnps=5) or sedentary time (nsnps=6), or accelerometer-measured (nsnps=1) or self-reported (nsnps=5) vigorous physical activity.RESULTS: Greater genetically-predicted overall activity was associated with lower breast cancer overall risk (OR=0.59; 95% confidence interval (CI) 0.42 to 0.83 per-standard deviation (SD;~8 milligravities acceleration)) and for most case-groups. Genetically-predicted vigorous activity was associated with lower risk of pre/perimenopausal breast cancer (OR=0.62; 95% CI 0.45 to 0.87,≥3 vs. 0 self-reported days/week), with consistent estimates for most case-groups. Greater genetically-predicted sedentary time was associated with higher hormone-receptor-negative tumour risk (OR=1.77; 95% CI 1.07 to 2.92 per-SD (~7% time spent sedentary)), with elevated estimates for most case-groups. Results were robust to sensitivity analyses examining pleiotropy (including weighted-median-MR, MR-Egger).CONCLUSION: Our study provides strong evidence that greater overall physical activity, greater vigorous activity, and lower sedentary time are likely to reduce breast cancer risk. More widespread adoption of active lifestyles may reduce the burden from the most common cancer in women.
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| 6. |
- Fall, Andreas, et al.
(författare)
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Spinning of Stiff and Conductive Filaments from Cellulose Nanofibrils and PEDOT:PSS Nanocomplexes
- 2022
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Ingår i: ACS Applied Polymer Materials. - : American Chemical Society (ACS). - 2637-6105. ; 4:6, s. 4119-4130
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Tidskriftsartikel (refereegranskat)abstract
- Research in smart textiles is growing due to the increased demand from the healthcare sector and people's urge to keep track of and analyze the signals and metrics from their bodies. Electrically conductive filaments are the most fundamental material for smart textiles. These filaments can be imbued with functionalities and useful in fields like energy storage, sensing, and actuation. To be able to meet the requirements that the latter applications require, fabrication techniques must be developed to provide better processability and sustainability in a cost-effective manner. Here, a mixture of a conductive polymer, poly(3,4-ethylenedioxythiophene) (PEDOT), and biobased cellulose nanofibrils (CNFs) was used to spin filaments utilizing a water-based process. These filaments show electrical conductivities up to 150 S/cm and tensile stiffness of 20 GPa. Interestingly, the PEDOT aligned to a similar degree as the CNFs during the spinning process without a drawing step, which is hypothesized to be caused by the attachment of PEDOT on the CNFs. Lastly, the filaments were tested in an organic electrochemical transistor (OECT) configuration, which resulted in a working device with an on/off ratio approaching 1500. Furthermore, the OECT exhibited stable behavior when changing temperature (20-80 °C) and relative humidity (40-80%). This aqueous spinning method, resulting in filaments with robust electronic properties in different temperature and humidity environments, show greats promise for future innovative smart textiles.
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| 7. |
- Grelle, Achim, et al.
(författare)
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From source to sink : recovery of the carbon balance in young forests
- 2023
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Ingår i: Agricultural and Forest Meteorology. - : Elsevier. - 0168-1923 .- 1873-2240. ; 330
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Tidskriftsartikel (refereegranskat)abstract
- We analyzed ecosystem carbon fluxes from eddy-covariance measurements in five young forests in southernSweden where the previous stand had been harvested by clear-cutting or wind-felled: three stands with Norwayspruce (Picea abies (L.) Karst.), one with Scots pine (Pinus sylvestris) and one with Larch (Larix x eurolepis A.Henry). One of the spruce stands had the stumps harvested, one was fertilized and one without any specialtreatments. These stands returned from positive (sources) to negative (sinks) annual carbon fluxes 8–13 yearsafter disturbance, depending on site productivity and management. This corresponds to approximately 15% ofthe rotation periods at these sites. Extrapolation in combination with chronosequence data suggests thatconventionally regenerated stands reach a neutral carbon balance after approximately 30% of the rotationperiod. The lowest carbon emissions and shortest recovery time was observed in a stand where the stumps of thetrees, in addition to the stems and logging residues, were removed after harvest. This stand not only returned to acarbon sink within this time period but the total carbon gains since disturbance also equaled the total losses afteronly 11 years. These results stress that production stands in southern Sweden are carbon sources during arelatively small part of the rotation period, and that this part can be considerably shortened by measures thatincrease productivity or reduce the amount of woody debris left after disturbance.
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| 8. |
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| 9. |
- Hovbrandt, Pia, et al.
(författare)
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Psychosocial working conditions and social participation. A 10-year follow-up of senior workers.
- 2021
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Ingår i: International Journal of Environmental Research and Public Health. - : MDPI AG. - 1660-4601. ; 18:17, s. 1-14
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Tidskriftsartikel (refereegranskat)abstract
- Social participation is important for health, and it is well known that high strain jobs impact negatively on mental and physical health. However, knowledge about the impact of psychosocial working conditions on social participation from a long-term perspective is lacking. The purpose of this study was to investigate the associations between different job types and social participation from a long-term perspective. A comprehensive public health questionnaire “The Scania Public Health Survey”, was used, and psychosocial working conditions were measured with a Swedish translation of the Job Content Questionnaire. Based on data from 1098 working respondents aged 55 at baseline and a 10-year follow-up when the respondents were not working, the analyses revealed that social participation varied by job type. Jobs with high decision latitude, as in active and relaxed jobs, seem to predict high social participation, even after cessation of employment. Besides that, the result suggests that high social participation during working life is a predictor of high social participation from a long-term perspective which promotes healthy aging. Incentives for working longer are strongly related to good working conditions. A supportive work environment with possibilities for employees to participate in decision making, i.e., high control, is vital for a sustainable working life. This may contribute to an extended working life and may also support social participation prior to retirement as well as after retirement and thus to healthy aging.
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| 10. |
- Håkansson, Charlotta, 1971-, et al.
(författare)
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Effects of fertilization on soil CH4 and N2O fluxes in young Norway spruce stands
- 2021
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Ingår i: Forest Ecology and Management. - : Elsevier. - 0378-1127 .- 1872-7042. ; 499
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Tidskriftsartikel (refereegranskat)abstract
- Climate change mitigation strategies have increased the demand for wood products, resulting in an urgent needto increase wood production. One approach is to fertilize forest land, but this can influence greenhouse gas (GHG) fluxes within the ecosystem. The aim of this study was to examine the effects of forest N fertilization onsoil CH4 and N2O fluxes in young Norway spruce (Picea abies (L.) Karst.) stands in southern Sweden. The gasfluxes were measured using flow-through non-steady-state dark chambers. In the first, long-term, experiment,half of the stand was fertilized twice (once in 2014 and once in 2016) with 150 kg ha-1 of N, and gas fluxmeasurements were taken throughout 2014–2017. In the second, dose, experiment, 0, 150, 300, or 450 kg ha-1 of N was added to the stand in April 2016, and gas flux measurements were taken during April-December 2016.The dose experiment showed that the sink strength of CH4 decreased with increasing amounts of N; the long-termexperiment indicated that repeated fertilization decreased the CH4 sink strength over time. Additionally, thelong-term experiment indicated that, while significantly higher N2O emissions were recorded in the fertilizationyears, this was not detected in subsequent years, suggesting the effect to be short-lived. In the dose experiment,fertilization tended to increase the N2O emissions relative to the amount of fertilizer. However, despite thesignificant effects of fertilization on these GHGs, the summed fluxes were a fraction of the net uptake of C at thesites, as recorded in another study. These findings suggest that fertilizing forest land with commercial NP or NPKfertilizers corresponding to 150 kg ha-1 of N, the level used in operational forestry in Sweden today, can beconducted without changing CH4 and N2O fluxes to any great extent.
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