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- Branström, J., et al.
(författare)
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Compression wood in knots and the effect on surface roughness.
- 2005
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Ingår i: proceedings from IMPC 2005.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The microstructural and ultrastructural characteristics of knot wood were examined and related to paper properties. Norway spruce (Picea abies) chips were laboratory fractionated and sorted into a knot containing assortment and a non knot containing reference assortment. The proportions of compression wood in these two assortments were then assessed and the two chip assortments refined in pilot refiners. The knot containing portion was divided into wood from the upper branch, wood from the lower branch compression wood and wood surrounding the branch. Fibres from the three knotwood portions and the reference chips were extracted and measurements were made of fibre properties including fibre length, fibre width and cell wall thickness. The two chip assortments were refined in a pilot plant and the surface properties of laboratory sheets were measured. The knot containing chips had adverse effects on several paper properties. However, no clear relationship was established between surface roughness and the presence of compression wood fibres in knot wood. (6 fig, 12 ref)
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| 2. |
- Ekblom, Robert, et al.
(författare)
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Female choice and male humoral immune response in the lekking great snipe (Gallinago media)
- 2005
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Ingår i: Behavioral Ecology. - : Oxford University Press (OUP). - 1045-2249 .- 1465-7279. ; 16:2, s. 346-351
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Tidskriftsartikel (refereegranskat)abstract
- Parasites and diseases constitute major evolutionary forces in many natural populations, and thus having an efficient immune defense to resist infections is crucial for many organisms. Properties of the immune response may also influence mate choice decisions in many animals. Theory predicts several advantages for females when choosing males with superior immune systems. These benefits can be both direct (e.g. increased paternal care and reduced disease transmission) and indirect (good genes). We have investigated female choice with respect to antibody response to two novel antigens in males of a lekking bird, the great snipe (Gallinago media). Because of the lek mating system, female choice probably mainly incurs indirect (genetic) rather than direct benefits. Males responded to vaccination with diphtheria and tetanus toxoids by producing specific antibodies to both antigens. Triggering the immune system had no negative impact on display activities or survival. Males that were chosen by females as mates had on average higher antibody response to the tetanus antigen than their neighbors. We did not, however, find any covariance between the strength of the antibody response and male mating success.
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| 4. |
- Höglund, Kina, 1976, et al.
(författare)
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Prediction of Alzheimer's disease using a cerebrospinal fluid pattern of C-terminally truncated beta-amyloid peptides.
- 2008
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Ingår i: Neuro-degenerative diseases. - : S. Karger AG. - 1660-2862 .- 1660-2854. ; 5:5, s. 268-76
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: Identifying individuals at high risk of developing Alzheimer's disease (AD) is important for future therapeutic strategies, and there is a clinical need for diagnostic biomarkers to identify incipient AD. OBJECTIVE: The aim of the present study was to investigate if the AD-associated Abeta peptide pattern recently found in cerebrospinal fluid (CSF) could discriminate between patients with incipient AD and those with stable mild cognitive impairment (MCI) by analyzing CSF from patients with MCI at baseline. METHODS: The levels of Abeta(1-37, -38, -39, -40, -42) were analyzed by Abeta-SDS-PAGE/immunoblot in CSF from 19 healthy controls, 25 patients with stable MCI and from 25 patients with MCI who later developed AD during 4- to 6-year follow-up. RESULTS: All healthy controls and 20 out of 22 patients who developed AD were correctly classified by their baseline Abeta peptide pattern. In 9 out of 25 stable MCI patients, the pattern indicated incipient AD in spite of clinical nonconversion. Interestingly, these individuals had apolipoprotein E genotypes and CSF levels of tau and phospho-tau that are known to be associated with high risk of AD. CONCLUSION: Altogether, our study reveals the novel finding that the Abeta peptide pattern is able to predict AD in patients with MCI with a sensitivity of 91% and specificity of 64%. The specificity would increase to 94% if the high-risk patients in the stable MCI cohort developed AD during extended follow-up.
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| 9. |
- Höglund, P
(författare)
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DNA damage and tumor surveillance: one trigger for two pathways
- 2006
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Ingår i: Science's STKE : signal transduction knowledge environment. - : American Association for the Advancement of Science (AAAS). - 1525-8882. ; 2006:317, s. pe2-
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Tidskriftsartikel (refereegranskat)abstract
- Biological evolution ensures that several backup mechanisms always exist to prevent the failure of cellular processes of critical importance for life. This notion applies to processes aimed at preventing cancer development. Recent research suggests that the DNA damage response, activated in one of the earliest cellular responses to transformation, may elicit two independent tumor surveillance mechanisms. The first, and most well known, is activation of the proapoptotic molecule p53 and subsequent cellular suicide. The second, reported in a recent study, is induction of the expression of ligands for the activating immune receptor NKG2D. That DNA damage induces two independent tumor surveillance responses demonstrates how one tumor surveillance mechanism may be assisted by another to secure efficient protection against early tumorigenesis. The results also support the immunosurveillance theory of cancer and suggest that it may operate at very early stages of tumorigenesis.
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