| 1. |
- Hagberg, Hans, et al.
(författare)
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Follicular lymphoma in Sweden: nationwide improved survival in the rituximab era, particularly in elderly women: a Swedish Lymphoma Registry Study
- 2015
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Ingår i: Leukemia. - : Springer Science and Business Media LLC. - 0887-6924 .- 1476-5551. ; 29:3, s. 668-676
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Tidskriftsartikel (refereegranskat)abstract
- Treatment for follicular lymphoma (FL) improved with rituximab. In Sweden, first-line rituximab was gradually introduced between 2003 and 2007, with regional differences. The first national guidelines for FL were published in November 2007, recommending rituximab in first-line therapy. Using the population-based Swedish Lymphoma Registry, 2641 patients diagnosed with FL from 2000 to 2010 were identified and characterized by year and region of diagnosis, age (median, 65 years), gender (50% men), first-line therapy and clinical risk factors. Overall and relative survivals were estimated by calendar periods (2000-2002, 2003-2007 and 2008-2010) and region of diagnosis. With each period, first-line rituximab use and survival increased. Survival was superior in regions where rituximab was quickly adopted and inferior where slowly adopted. These differences were independent in multivariable analyses. Ten-year relative survival for patients diagnosed 2003-2010 was 92%, 83%, 78% and 64% in the age groups 18-49, 50-59, 60-69 and ≥70, respectively. With increasing rituximab use, male sex emerged as an adverse factor. Survival improved in all patient categories, particularly in elderly women. The introduction and the establishment of rituximab have led to a nationwide improvement in FL survival. However, rituximab might be inadequately dosed in younger women and men of all ages. © 2015 Macmillan Publishers Limited. All rights reserved.
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| 2. |
- Semb, G, et al.
(författare)
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Erratum
- 2017
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Ingår i: Journal of plastic surgery and hand surgery. - 2000-6764. ; 51:2, s. 158-158
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Tidskriftsartikel (refereegranskat)
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| 3. |
- Elden, Helen, 1959, et al.
(författare)
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Study protocol of SWEPIS a Swedish multicentre register based randomised controlled trial to compare induction of labour at 41 completed gestational weeks versus expectant management and induction at 42 completed gestational weeks
- 2016
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Ingår i: Bmc Pregnancy and Childbirth. - : Springer Science and Business Media LLC. - 1471-2393. ; 16:49
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Tidskriftsartikel (refereegranskat)abstract
- Background: Observational data shows that postterm pregnancy (>= 42 gestational weeks, GW) and late term pregnancy (>= 41 GW), as compared to term pregnancy, is associated with an increased risk for adverse outcome for the mother and infant. Standard care in many countries is induction of labour at 42 GW. There is insufficient scientific support that induction of labour at 41 GW, as compared with expectant management and induction at 42 GW will reduce perinatal mortality and morbidity without an increase in operative deliveries, negative delivery experiences or higher costs. Large randomised studies are needed since important outcomes; such as perinatal mortality and hypoxic ischaemic encephalopathy are rare events. Methods/Design: A total of 10 038 healthy women >= 18 years old with a normal live singleton pregnancy in cephalic presentation at 41 GW estimated with a first or second trimester ultrasound, who is able to understand oral and written information will be randomised to labour induction at 41 GW (early induction) or expectant management and induction at 42 GW (late induction). Women will be recruited at university clinics and county hospitals in Sweden comprising more than 65 000 deliveries per year. Primary outcome will be a composite of stillbirth, neonatal mortality and severe neonatal morbidity. Secondary outcomes will be other adverse neonatal and maternal outcomes, mode of delivery, women's experience, cost effectiveness and infant morbidity up to 3 months of age. Data on background variables, obstetric and neonatal outcomes will be obtained from the Swedish Pregnancy Register and the Swedish Neonatal Quality Register. Data on women's experiences will be collected by questionnaires after randomisation and 3 months after delivery. Primary analysis will be intention to treat. The statistician will be blinded to group and intervention. Discussion: It is important to investigate if an intervention at 41 GW is superior to standard care in order to reduce death and lifelong disability for the children. The pregnant population, >41 GW, constitutes 15-20 % of all pregnancies and the results of the study will thus have a great impact. The use of registries for randomisation and collection of outcome data represents a unique and new study design.
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| 4. |
- Hagberg, C. E., et al.
(författare)
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Flow Cytometry of Mouse and Human Adipocytes for the Analysis of Browning and Cellular Heterogeneity
- 2018
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Ingår i: Cell Reports. - : Elsevier BV. - 2211-1247. ; 24:10
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Tidskriftsartikel (refereegranskat)abstract
- Adipocytes, once considered simple lipid-storing cells, are rapidly emerging as complex cells with many biologically diverse functions. A powerful high-throughput method for analyzing single cells is flow cytometry. Several groups have attempted to analyze and sort freshly isolated adipocytes; however, using an adipocyte-specific reporter mouse, we demonstrate that these studies fail to detect the majority of white adipocytes. We define critical settings required for adipocyte flow cytometry and provide a rigid strategy for analyzing and sorting white and brown adipocyte populations. The applicability of our protocol is shown by sorting mouse adipocytes based on size or UCP1 expression and demonstrating that a subset of human adipocytes lacks the beta(2)-adrenergic receptor, particularly in the insulin-resistant state. In conclusion, the present study confers key technological insights for analyzing and sorting mature adipocytes, opening up numerous downstream research applications.
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| 5. |
- Hagberg, Sten, 1962-, et al.
(författare)
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Démocratie par le bas et politique municipale au Sahel
- 2019. - 1
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Cet ouvrage collectif engage une analyse ethnographique des communes sahéliennes, notamment celles du Burkina Faso, du Mali et du Niger. A travers des études de cas, l’idée est de décrire la démocratie locale telle qu’elle est pratiquée au niveau municipal. La commune est au cœur de la réflexion pour plusieurs raisons. C’est dans la commune que les plans de développement sont mis en œuvre. La commune est aussi le lieu où les politiques publiques prennent corps dans la vie quotidienne des citoyens. Elle est également l’espace local où la réalisation d’infrastructures et d’actions de développement se concrétise. La commune abrite le conseil municipal, cette nouvelle institution locale. C’est dans la commune que « la forme » et « la substance » de la démocratie se confrontent.La commune sahélienne est une arène, un espace public, une représentation culturelle, une institution nouvelle et un enjeu. Elle est « le retour à la maison » en même temps qu’elle est une nouvelle création de l’État. La commune et ses représentants sont traités de tous les noms ; elle est la cible des ragots et des revendications, des mobilisations et des manquements, des développements et des détournements.L’ouvrage est le résultat de plusieurs projets de recherche entre le Département d’anthropologie culturelle et d’ethnologie / Forum for Africa Studies de l’université d’Uppsala (Suède), l’Institut des sciences des sociétés du Centre National de la Recherche Scientifique et Technologique (Burkina Faso) et le centre de recherche Point Sud (Mali). La plupart de chapitres ont été écrits en tandem entre chercheurs seniors et juniors dans un esprit collaboratif engagé.
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| 6. |
- Hagberg, Sten, 1962-, et al.
(författare)
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Sécurité par le bas : Perceptions et perspectives citoyennes des défis de sécurité au Burkina Faso
- 2019
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Bok (övrigt vetenskapligt/konstnärligt)abstract
- Cette étude porte sur la sécurité par le bas au Burkina Faso, notamment les manières dont les citoyens perçoivent et vivent les défis de sécurité. A travers une entrée par la commune, elle s’intéresse à l’interface entre les enjeux locaux et les insécurités multiples : attaques armées, terrorisme, crime organisé, délinquances, exactions et bavures des forces de sécurité, pauvreté, insécurité alimentaire, etc. L’étude met les nouvelles initiatives de sécurité (Forum national de sécurité, la Force conjointe du G5 Sahel, groupes d’autodéfense, etc.) en perspective, car elle vise à comprendre les réalités et les « vues et vécues » des acteurs socio-politiques locaux et des citoyens ordinaires. L’étude est le fruit d’un travail collectif. Une équipe d’anthropologues a d’abord mené les recherches de terrain dans 13 communes burkinabè pour ensuite analyser les matériaux ethnographiques afin de rédiger le présent document ensemble. Les perspectives citoyennes de sécurité, l’ancien régime, la crise malienne, et la criminalité transfrontalière, sont analysées à côté des perceptions populaires de l’État burkinabè. L’émergence des groupes d’auto-défense, particulièrement les Dozos, Koglweogos et Roughas, est contextualisée, suivie d’une analyse des initiatives locales pour la sécurité, telles que l’engagement contre la radicalisation et la mobilisation des femmes. Comment vivre les insécurités – notamment les questions de sécurité alimentaire, de chômage et d’emploi et gérer la peur – est analysé en détail sur la base des connaissances approfondies des terrains de recherche.
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| 7. |
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| 8. |
- Semb, Gunvor, et al.
(författare)
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A Scandcleft randomised trials of primary surgery for unilateral cleft lip and palate: 1. Planning and management.
- 2017
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Ingår i: Journal of Plastic Surgery and Hand Surgery. - : Taylor & Francis. - 2000-656X .- 2000-6764. ; 51:1, s. 2-13
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Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND AND AIMS: Longstanding uncertainty surrounds the selection of surgical protocols for the closure of unilateral cleft lip and palate, and randomised trials have only rarely been performed. This paper is an introduction to three randomised trials of primary surgery for children born with complete unilateral cleft lip and palate (UCLP). It presents the protocol developed for the trials in CONSORT format, and describes the management structure that was developed to achieve the long-term engagement and commitment required to complete the project.METHOD: Ten established national or regional cleft centres participated. Lip and soft palate closure at 3-4 months, and hard palate closure at 12 months served as a common method in each trial. Trial 1 compared this with hard palate closure at 36 months. Trial 2 compared it with lip closure at 3-4 months and hard and soft palate closure at 12 months. Trial 3 compared it with lip and hard palate closure at 3-4 months and soft palate closure at 12 months. The primary outcomes were speech and dentofacial development, with a series of perioperative and longer-term secondary outcomes.RESULTS: Recruitment of 448 infants took place over a 9-year period, with 99.8% subsequent retention at 5 years.CONCLUSION: The series of reports that follow this introductory paper include comparisons at age 5 of surgical outcomes, speech outcomes, measures of dentofacial development and appearance, and parental satisfaction. The outcomes recorded and the numbers analysed for each outcome and time point are described in the series.TRIAL REGISTRATION: ISRCTN29932826.
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