Sökning: WFRF:(Hagenaars S.)
> (2006-2009) >
Morphological appea...
Morphological appearance, content of extracellular matrix and vascular density of lung metastases predicts permissiveness to infiltration by adoptively transferred natural killer and T cells.
-
Yang, Q. (författare)
-
Goding, S (författare)
-
Hagenaars, M (författare)
-
visa fler...
-
Carlos, T (författare)
-
Albertsson, Per, 1964 (författare)
-
Kuppen, P (författare)
-
- Nannmark, Ulf, 1958 (författare)
- Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för medicinsk kemi och cellbiologi,Institute of Biomedicine, Department of Medical Biochemistry and Cell Biology
-
Hokland, M E (författare)
-
Basse, P H (författare)
-
visa färre...
-
(creator_code:org_t)
- 2005-07-27
- 2006
- Engelska.
-
Ingår i: Cancer immunology, immunotherapy : CII. - : Springer Science and Business Media LLC. - 0340-7004 .- 1432-0851. ; 55:6, s. 699-707
- Relaterad länk:
-
https://gup.ub.gu.se...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- We have recently shown that adoptively transferred, IL-2-activated natural killer (A-NK) cells are able to eliminate well-established B16-F10.P1 melanoma lung metastases. However, some B16-F10.P1 lung metastases were resistant to infiltration by the A-NK cells and also resistant to the A-NK cell treatment. The infiltration-resistant (I-R) B16-F10.P1 metastases had a unique "compact" morphology compared to the "loose" morphology of the infiltration-permissive (I-P) metastases. Here, we show that I-P loose tumors and I-R compact tumors are also found in lung metastases of mouse Lewis lung carcinoma (3LL), MCA-102 sarcoma, and MC38 colon carcinoma as well as rat MADB106 mammary carcinoma origin. Furthermore, the infiltration resistance of the compact tumors is not restricted to A-NK cells, since PHA and IL-2 stimulated CD8+ T-cells (T-LAK cells) also infiltrated the compact tumors poorly. Analyses of tumors for extracellular matrix (ECM) components and PECAM-1(+) vasculature, revealed that the I-R lesions are hypovascularized and contain very little laminin, collagen and fibronectin. In contrast, the I-P loose tumors are well-vascularized and they contain high amounts of ECM components. Interestingly, the distribution pattern of ECM components in the I-P loose tumors is almost identical to that of the normal lung tissue, indicating that these tumors develop around the alveolar walls which provide the loose tumors with both a supporting tissue and a rich blood supply. In conclusion, tumor infiltration by activated NK and T cells correlates with the presence of ECM components and PECAM-1(+) vasculature in the malignant tissue. Thus, analysis of the distribution of ECM and vasculature in tumor biopsies may help select patients most likely to benefit from cellular adoptive immunotherapy.
Nyckelord
- Adoptive Transfer
- Animals
- Carcinoma
- Lewis Lung
- Extracellular Matrix
- chemistry
- immunology
- Female
- Killer Cells
- Natural
- immunology
- Lung Neoplasms
- blood supply
- immunology
- pathology
- Lymphocyte Subsets
- immunology
- Lymphocytes
- Tumor-Infiltrating
- immunology
- Mice
- Neoplasm Metastasis
- immunology
- pathology
- Rats
- T-Lymphocytes
- immunology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Yang, Q.
-
Goding, S
-
Hagenaars, M
-
Carlos, T
-
Albertsson, Per, ...
-
Kuppen, P
-
visa fler...
-
Nannmark, Ulf, 1 ...
-
Hokland, M E
-
Basse, P H
-
visa färre...
- Artiklar i publikationen
-
Cancer immunolog ...
- Av lärosätet
-
Göteborgs universitet