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Brachytherapy for P...
Brachytherapy for Pediatric Patients at Gustave Roussy Cancer Campus : A Model of International Cooperation for Highly Specialized Treatments
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- Chargari, Cyrus (författare)
- Institut Gustave Roussy
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- Haie-Meder, Christine (författare)
- Institut Gustave Roussy
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- Espenel, Sophie (författare)
- Institut Gustave Roussy
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Garcia, Max Adrien (författare)
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Ben-Arush, Myriam (författare)
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- Bolle, Stéphanie (författare)
- Institut Gustave Roussy
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- Borjesson, Anna (författare)
- Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Cesen, Maja (författare)
- University Children's Hospital, Ljubljana
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Lago, Rita Costa (författare)
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- Defachelles, Anne Sophie (författare)
- Centre Oscar Lambret
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- De Moerloose, Barbara (författare)
- Ghent University Hospital
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- Devalck, Christine (författare)
- Hopital Universitaire des Enfants Reine Fabiola
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- Edslev, Pernille (författare)
- Aarhus University Hospital
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Farinha, Nuno Jorge (författare)
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Francotte, Nadine (författare)
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- Glosli, Heidi (författare)
- Oslo university hospital
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- Gouy, Sebastien (författare)
- Institut Gustave Roussy
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- Burrieza, Gabriela Guillen (författare)
- Vall d'Hebron University Hospital
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- Helfre, Sylvie (författare)
- Curie Institute, Paris
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- Irtan, Sabine (författare)
- Paris-Sorbonne University
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- Kattamis, Antonis (författare)
- National and Kapodistrian University of Athens
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- Lacerda, Ana (författare)
- Portuguese Institute Of Oncology
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- Levy, Antonin (författare)
- Institut Gustave Roussy
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- Hjalgrim, Lisa Lyngsie (författare)
- Copenhagen University Hospital
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- Mansuy, Ludovic (författare)
- University Hospital of Nancy
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- Mascard, Eric (författare)
- Necker-Enfants Malades Hospital
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- Moalla, Salma (författare)
- Institut Gustave Roussy
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- Orbach, Daniel (författare)
- PSL University
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- Owens, Cormac (författare)
- Our Lady's Hospital for Sick Children
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- Philippe-Chomette, Pascale (författare)
- Hôpital universitaire Robert-Debré
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- Pizer, Barry (författare)
- Alder Hey Childrens Hospital
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- Pluchart, Claire (författare)
- Centre Hospitalier Universitaire Reims
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- Renard, Marleen (författare)
- University Hospitals Leuven
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- Rognlien, Anne Gro Wesenberg (författare)
- Oslo university hospital
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- Rome, Angélique (författare)
- La Timone University Hospital
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- Sarnacki, Sabine (författare)
- Necker-Enfants Malades Hospital
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- Safwat, Akmal (författare)
- Aarhus University Hospital
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- Schiavetti, Amalia (författare)
- Sapienza University of Rome
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- Serre, Jill (författare)
- University Hospital of Tours
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- Verite, Cécile (författare)
- Groupe Hospitalier Pellegrin
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- Weid, Nicolas Von Der (författare)
- University Children's Hospital, Basel
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Wysocki, Mariusz (författare)
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- Valteay-Couanet, Dominique (författare)
- Institut Gustave Roussy
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- Deutsch, Eric (författare)
- Institut Gustave Roussy
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- Minard-Colin, Véronique (författare)
- Institut Gustave Roussy
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- Martelli, Hélène (författare)
- University of Paris-Saclay
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- Guérin, Florent (författare)
- University of Paris-Saclay
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(creator_code:org_t)
- Elsevier BV, 2022
- 2022
- Engelska 12 s.
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Ingår i: International Journal of Radiation Oncology Biology Physics. - : Elsevier BV. - 0360-3016. ; 113:3, s. 602-613
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- Purpose: Childhood cancer is rare, and treatment is frequently associated with long-term morbidity. Disparities in survival and long-term side effects encourage the establishment of networks to increase access to complex organ-conservative strategies, such as brachytherapy. We report our experience of an international cooperation model in childhood cancers. Methods and Materials: We examined the outcome of all children referred to our center from national or international networks to be treated according to a multimodal organ-conservative approach, including brachytherapy. Results: We identified 305 patients whose median age at diagnosis was 2.2 years (range, 1.4 months to 17.2 years). Among these patients, 99 (32.4%) were treated between 2015 and 2020; 172 (56.4%) were referred from national centers; and 133 (43.6%) were international patients from 31 countries (mainly Europe). Also, 263 patients were referred for primary treatment and 42 patients were referred for salvage treatment. Genitourinary tumors were the most frequent sites, with 56.4% bladder/prostate rhabdomyosarcoma and 28.5% gynecologic tumors. In addition to brachytherapy, local treatment consisted of partial tumor resection in 207 patients (67.9%), and 39 patients (13%) had additional external radiation therapy. Median follow-up was 58 months (range, 1 month to 48 years), 93 months for national patients, and 37 months for international patients (P < .0001). Five-year local control, disease-free survival, and overall survival rates were 90.8% (95% confidence interval [CI], 87.3%-94.4%), 84.4% (95% CI, 80.1%-89.0%), and 93.3% (95% CI, 90.1%-96.5%), respectively. Patients referred for salvage treatment had poorer disease-free survival (P < .01). Implementation of image guided pulse-dose-rate brachytherapy was associated with better local control among patients with rhabdomyosarcoma referred for primary treatment (hazard ratio, 9.72; 95% CI, 1.24-71.0). At last follow-up, 16.7% patients had long-term severe treatment-related complications, and 2 patients (0.7%) had developed second malignancy. Conclusions: This retrospective series shows the feasibility of a multinational referral network for brachytherapy allowing high patient numbers in rare pediatric cancers. High local control probability and acceptable late severe complication probability could be achieved despite very challenging situations. This cooperation model could serve as a basis for generating international reference networks for high-tech radiation such as brachytherapy to increase treatment care opportunities and cure probability.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
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Chargari, Cyrus
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Haie-Meder, Chri ...
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Espenel, Sophie
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Garcia, Max Adri ...
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Ben-Arush, Myria ...
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Bolle, Stéphanie
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visa fler...
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Borjesson, Anna
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Cesen, Maja
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Lago, Rita Costa
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Defachelles, Ann ...
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De Moerloose, Ba ...
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Devalck, Christi ...
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Edslev, Pernille
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Farinha, Nuno Jo ...
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Francotte, Nadin ...
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Glosli, Heidi
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Gouy, Sebastien
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Burrieza, Gabrie ...
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Helfre, Sylvie
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Irtan, Sabine
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Kattamis, Antoni ...
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Lacerda, Ana
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Levy, Antonin
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Hjalgrim, Lisa L ...
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Mansuy, Ludovic
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Mascard, Eric
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Moalla, Salma
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Orbach, Daniel
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Owens, Cormac
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Philippe-Chomett ...
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Pizer, Barry
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Pluchart, Claire
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Renard, Marleen
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Rognlien, Anne G ...
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Rome, Angélique
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Sarnacki, Sabine
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Safwat, Akmal
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Schiavetti, Amal ...
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Serre, Jill
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Verite, Cécile
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Weid, Nicolas Vo ...
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Wysocki, Mariusz
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Valteay-Couanet, ...
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Deutsch, Eric
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Minard-Colin, Vé ...
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Martelli, Hélène
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Guérin, Florent
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