| 1. |
- Li, F, et al.
(författare)
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Recruitment of multiple cell lines by collagen-synthetic copolymer matrices in corneal regeneration
- 2005
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Ingår i: Biomaterials. - : Elsevier. - 0142-9612 .- 1878-5905. ; 26:16, s. 3093-3104
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Tidskriftsartikel (refereegranskat)abstract
- Collagen hydrogel matrices with high optical clarity have been developed from collagen 1, cross-linked with a copolymer based on N-isopropylacrylamide, acrylic acid and acryloxysuccinimide. The controlled reaction of collagen amine groups with this copolymer under neutral pH and aqueous conditions gave robust, optically clear hydrogels and prevented the excessive collagen fibrillogenesis that can lead to collagen opacity. These sterile, non-cytotoxic hydrogels allowed epithelial cell overgrowth and both stromal cell and nerve neurite ingrowth from the host tissue. This regenerative ability appeared to result from the high glucose permeability, nanoporosity and the presence of cell adhesion factors, RGD in collagen and the laminin pentapeptide, YIGSR, grafted onto the copolymer. Under physiological conditions, optical clarity superior to the human cornea and tensile performance adequate for suturing were obtained from some formulations. (C) 2004 Elsevier Ltd. All rights reserved.
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| 2. |
- Said, Safwat F, et al.
(författare)
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Evaluering av asfaltkonstruktion : E6 Fastarp-Heberg
- 2008
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Rapport (populärvet., debatt m.m.)abstract
- During the years 1994-1996 a test road was built on E6 near Halmstad. The test road has now been trafficked, and simultaneously studied since 1996. For the present study two test sections were chosen with different bituminous mixes which were to be evaluated concerning damages caused by traffic. One of the constructions is made of the so called FAS-concept, while the other construction is a reference section with conventional roadbase mix (AG22). Wearing course, binder layer and roadbase of the section with FAS-concept is produced by NCC according to their own concept called VIACO, which is based on the idea of using stone mastic asphalt (SMA) principle for all bituminous bound layers. The evaluation is based on laboratory studies of bore cores, an analysis of falling weight measurements, temperature measurements from field stations and theoretical calculations. The main purpose of this project is to evaluate alternative bituminous constructions and to present an evaluation method with relevant criteria concerning the service life related to fatigue cracking. The FAS-concept, which implies that material of good quality is chosen and that the stresses on the construction are diminished, has shown considerable longer fatigue life than the construction with conventional mixes. The fatigue life of the FAS-concept is several times longer that the fatigue life of the reference section. The strains in the lower part of the pavement are small and the risk of fatigue cracks at the bottom of the bituminous bound layer is minimal.
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