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Prevalence of adver...
Prevalence of adverse pregnancy outcomes after exposure to interferon beta prior to or during pregnancy in women with MS : Stratification by maternal and newborn characteristics in a register-based cohort study in Finland and Sweden
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- Korjagina, Marta (författare)
- StatFinn-EPID Research, Tallinn, Estonia
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- Hakkarainen, Katja M. (författare)
- StatFinn-EPID Research, Mölndal, Sweden
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- Burkill, Sarah (författare)
- Karolinska Institute, Solna, Sweden
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- Geissbühler, Yvonne (författare)
- Novartis Pharma AG, Evidence and Launch Excellence, Basel, Switzerland
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- Sabidó, Meritxell (författare)
- Merck KGaA, Darmstadt, Germany
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- Everage, Nicholas (författare)
- Biogen, Cambridge, MA, United States
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- Suzart-Woischnik, Kiliana (författare)
- Bayer AG, Berlin, Germany
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- Klement, Riho (författare)
- StatFinn-EPID Research, Tartu, Estonia
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- Hillert, Jan (författare)
- Karolinska Institutet
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- Verkkoniemi-Ahola, Auli (författare)
- Clinical Neurosciences, Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland
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- Bahmanyar, Shahram (författare)
- Centre for Pharmacoepidemiology, Department of Medicine, Karolinska Institutet, Solna, Sweden; Centre for Psychiatry Research, Karolinska Institutet, Norra Stationsgatan 69, floor 7, 113 64 Stockholm, Sweden; Stockholm Health Care Services, Stockholm, Sweden
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- Montgomery, Scott, 1961- (författare)
- Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Clinical Epidemiology Division, Department of Medicine, Karolinska Institute, Solna, Sweden; Örebro University Hospital, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics
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- Korhonen, Pasi (författare)
- StatFinn-EPID Research, Espoo, Finland
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(creator_code:org_t)
- Elsevier, 2020
- 2020
- Engelska.
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Ingår i: Multiple Sclerosis and Related Disorders. - : Elsevier. - 2211-0348 .- 2211-0356. ; 48
- Relaterad länk:
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https://doi.org/10.1...
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http://www.msard-jou...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND: Previous studies reported no increase in the prevalence of adverse pregnancy outcomes after exposure to interferon-beta (IFN-beta). However, no study has investigated if the prevalence of these outcomes after IFN-beta exposure is modified by maternal and newborn characteristics. Our objective was to describe the stratified prevalence of adverse pregnancy outcomes among women with multiple sclerosis (MS) exposed only to IFN-beta or unexposed to any MS disease modifying drugs (MSDMDs).METHODS: This population-based cohort study using Finnish (1996-2014) and Swedish (2005-2014) register data included pregnancies of women with MS exposed only to IFN-beta 6 months before or during pregnancy (n=718) or unexposed to MSDMDs (n=1397). The outcome prevalences were described stratified by maternal and newborn characteristics, with 95% confidence intervals (CIs). Confounder-adjusted analyses were performed if the prevalence results indicated modified effect of IFN-beta in specific strata.RESULTS: The stratified analysis indicated that the prevalence of serious (anomaly or stillbirth) and other adverse pregnancy outcomes was similar among the exposed and unexposed, with no statistically significant difference. Among women treated for MS >5 years, serious adverse pregnancy outcomes occurred in 4.3% (95%CI: 1.9-8.3%) of pregnancies exposed only to IFN-beta 6 months before or during pregnancy and in 2.7% (95%CI: 1.2-5.0%) of unexposed pregnancies. The confounder adjusted analyses did not support the hypothesis that MS treatment duration before pregnancy would modify the risk of adverse pregnancy outcomes after exposure to IFN-beta 6 months before or during pregnancy.CONCLUSION: The prevalence of adverse pregnancy outcomes was not increased after IFN-beta exposure, when pregnancies of women with MS were stratified by maternal and newborn characteristics. The stratified results were similar to the unstratified results in the same population.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- Adverse pregnancy outcomes
- Interferon-beta
- Multiple sclerosis
- Pregnancy
- Stratification
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- art (ämneskategori)
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Korjagina, Marta
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Hakkarainen, Kat ...
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Burkill, Sarah
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Geissbühler, Yvo ...
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Sabidó, Meritxel ...
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Everage, Nichola ...
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Suzart-Woischnik ...
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Klement, Riho
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Hillert, Jan
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Verkkoniemi-Ahol ...
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Bahmanyar, Shahr ...
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Montgomery, Scot ...
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Korhonen, Pasi
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Örebro universitet
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