Sökning: WFRF:(Halasz L)
> (1999) >
Relation between GB...
Relation between GB virus C/hepatitis G virus and fulminant hepatic failure may be secondary to treatment with contaminated blood and/or blood products
-
Halasz, R (författare)
-
Barkholt, L (författare)
-
Lara, C (författare)
-
visa fler...
-
- Hultgren, C (författare)
- Karolinska Institutet
-
Ando, Y (författare)
-
Broome, U (författare)
-
- Fischler, B (författare)
- Karolinska Institutet
-
- Nemeth, A (författare)
- Karolinska Institutet
-
- Ericzon, BG (författare)
- Karolinska Institutet
-
- Sonnerborg, A (författare)
- Karolinska Institutet
-
- Sallberg, M (författare)
- Karolinska Institutet
-
visa färre...
-
(creator_code:org_t)
- 1999-02-01
- 1999
- Engelska.
-
Ingår i: Gut. - : BMJ. - 0017-5749 .- 1468-3288. ; 44:2, s. 274-278
- Relaterad länk:
-
https://gut.bmj.com/...
-
visa fler...
-
http://kipublication...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The role of the recently discovered GB virus C (GBV-C)/hepatitis G virus in fulminant hepatic failure (FHF) has been debated. Although GBV-C RNA has been detected in many cases of FHF, recent data suggest that the relation between GBV-C and FHF may be accidental.AimsTo retrospectively investigate the possible relation between the presence of GBV-C markers (RNA or antibodies to the GBV-C envelope 2 (E2) glycoprotein) and FHF.MethodsThe presence of GBV-C RNA was determined in serum samples from 58 patients diagnosed with FHF using a reverse transcriptase polymerase chain reaction. Amplified genetic fragments were directly sequenced by the dideoxy chain termination method. Antibodies to GBV-C in serum samples were detected by enzyme immunoassay based on a recombinant GBV-C E2 protein.ResultsNine (16%) patients with FHF had GBV-C RNA and 14 (24%) had GBV-C E2 antibodies, which are higher frequencies than in healthy subjects (p<0.01 and p<0.05 respectively). Seven of ten patients with GBV-C markers during FHF tested negative for these markers before therapy with blood and/or blood products. Sequence analysis of the GBV-C NS3 region fragments of six FHF patients showed no common sequence pattern or motif.ConclusionsThe frequencies of both GBV-C RNA and antibodies are higher in patients with FHF than in healthy subjects. However, these increased frequencies may in many cases be explained by the use of contaminated blood and/or blood products given as therapy.
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
Gut
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Halasz, R
-
Barkholt, L
-
Lara, C
-
Hultgren, C
-
Ando, Y
-
Broome, U
-
visa fler...
-
Fischler, B
-
Nemeth, A
-
Ericzon, BG
-
Sonnerborg, A
-
Sallberg, M
-
visa färre...
- Artiklar i publikationen
-
Gut
- Av lärosätet
-
Karolinska Institutet