| 1. |
- Jansson, Ann, 1950, et al.
(författare)
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Role of a consensus AP-2 regulatory sequence within the Epstein-Barr Virus LMP1 promoter in EBNA2 mediated transactivation
- 2007
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Ingår i: Virus Genes. - : Springer Science and Business Media LLC. - 0920-8569 .- 1572-994X. ; 35:2, s. 203-14
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Tidskriftsartikel (refereegranskat)abstract
- The Epstein-Barr virus (EBV) tumor-associated latent membrane protein 1 (LMP1) gene expression is transactivated by EBV nuclear antigen 2 (EBNA2) in human B cells. We previously reported that an E-box element at the LMP1 regulatory sequence (LRS) represses transcription of the LMP1 gene through the recruitment of a Max-Mad1-mSin3A complex. In the present study, using deletion/mutation analysis, and electrophoretic mobility shift assays, we show that the promoter region adjacent to the E-box (-59/-67) is required for the full repression conferred by E-box binding proteins. The repressive effect of these factors was overcome by an inhibitor of histone deacetylation, Trichostatin A (TSA), concurring with the reports that histone deacetylation plays an important role in repression mediated by Max-Mad1-mSin3A complex. Furthermore, ChIP analyses showed that histones at the transcriptionally active LMP1 promoter were hyperacetylated, whereas in the absence of transcription they were hypoacetylated. EBNA2 activation of the promoter required a consensus AP-2 sequence in the -103/-95 LRS region. While EMSA results and the low level of AP-2 factors expression in B cells argue against known AP-2 factors binding to this site, several pieces of evidence point to a similar mechanism of promoter activation as seen by AP-2 factors. We conclude that an AP-2 site-binding factor and EBNA2 act in concert to overcome the repression of the LMP1 promoter via the consensus AP-2 site. This activation showed strong correlation with histone hyperacetylation at the promoter, indicating this to be a major mechanism for the EBNA2 mediated LMP1 transactivation.
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| 2. |
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| 3. |
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| 4. |
- Berger, Gertrud, et al.
(författare)
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Information visualization for product development in the LIVA project
- 2008
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Ingår i: InfoTrend. - : Svensk förening för informationsspecialister. - 1653-0225. ; 63:1, s. 3-13
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Tidskriftsartikel (populärvet., debatt m.m.)abstract
- The LIVA research and development project (2005-2007) was conceived to integrate automatic indexing, automatic categorization, information visualization and information retrieval in library systems managing textual document collections. After a brief overview of some major information visualization methods, the user interface prototype is introduced.
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| 5. |
- Bergh, Gunnar, et al.
(författare)
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En svensk magister håller
- 2007
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Ingår i: Upsala Nya Tidning. - Uppsala : Uppsala Nya Tidning. - 1104-0173. ; :2 april
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Tidskriftsartikel (populärvet., debatt m.m.)
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| 6. |
- Bergman, Anette, et al.
(författare)
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Electronic communication in strategic networks
- 2003
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Ingår i: 19th Annual IMP Conference University of Lugano, Switzerland, 4th–6th September 2003.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The email communication in a strategic network of small and medium-sized firms in the Stockholm metropolitan area is analysed on the basis a classification model for communication reasons. Support is found for email use according to information richness theory, as the dominant use of email was information dissemination. However, email was also used for tasks not typical for lean communication media, e.g., the expression of emotions. Still more striking is the strong impact of social behaviour and expectations as a precondition for the actual use of email. Although the strategic network is built up around a web-based platform, email is only marginally used for communication in the network as an effect of low coherence in the network and limited computer experience.
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| 7. |
- Bergman, Anette, et al.
(författare)
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The use of information in strategic business networks
- 2002
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The strategic network actors use modern information technology in order to link activities and tie resources. Common means of transferring written information are EDI and e-mail. The manner in which actors use written information to secure resources is therefore an essential issue for the development of strategic networks. The focus of this working paper is how the actors in a strategic networks use written information by way of e-mail. Since knowledge of how actors use written information by e-mail is limited, this paper endeavours to clarify how e-mail are used and to find factors to explain this use on the basis of the interaction and the network approach. There are three different purposes for using written information by e-mail. The actor could use the e-mail in order to coordinate activities, to control individuals and organizational units and to gain and provide new knowledge. In this paper we are concentrated on the controlling category. It is possible, according to Gadde & Håkansson (1993), to classify written information by e-mail into three different categories. The first category deals with the product, or the seller�s ability to resolve a problem the buyer may have, and its characteristics. The second category deals with the commercial terms negotiated before the decision to buy was made, i.e. the information the buyer requires making the order (prices, discounts, terms of delivery and payment). The third category deals with the structure of the transaction (appointments, volumes, method of delivery, formal rules and routines). The first category is referred to in this paper as the technical content, the second category as the commercial content, and the third category as the administrative content. In this paper we try to classify the written information by e-mail into the three different categories and then attempt to examine just how the actors use written information by way of e-mail to control organizational units and individuals.
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| 8. |
- Bäcklund, Jonas, 1967-
(författare)
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Arguing for Relevance : Global and local knolwdge claims in management consulting
- 2003
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Management consulting services are often viewed as local in the sense that they are based on knowledge of local conditions, are adapted to those conditions, and build on client interaction. Despite this view, globally active consulting firms continue to increase in number and relative size in national markets. To address this paradox and to understand the demand for globally active management consulting services, the present study investigated the efforts of consulting firms to be persuasive, and the ideational embeddeness of those efforts. This was done by examining how management consulting firms present their services in three media in the Swedish market for management consulting: public tenders, corporate web sites, and a yearly listing of the actors in the market, with special attention to ideas on management and organization drawn upon by the firms in their efforts to be persuasive. Three distinct presentation profiles were identified and linked to categories of consulting firms. Although varying considerably, the profiles drew on common ideas, viz., management as a de-contextualized, global and scientific activity. Offering structured models and standardized tools was seen to provide advantages to consulting firms claiming to be able to do so. Local aspects of management, such as culture, were generally de-emphasized as a source of legitimacy in the presentations.By considering how processes of consulting-firm legitimization through presentations make part of the structuring of non-regulated fields, the study contributes to a discussion of the interdependence of the evolution of the consulting industry and the development and diffusion of general ideas on management.
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| 10. |
- Elbe, Jörgen, et al.
(författare)
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Mobilizing marginal resources for public events
- 2007
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Ingår i: Event Management. - : Cognizant, LLC. - 1525-9951 .- 1943-4308. ; 10:2-3, s. 175-183
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Tidskriftsartikel (refereegranskat)abstract
- Marginal resources are important for organizers of public events. In the present context, marginal resources are defined as resources that providers can offer to events in periods when these resources cannot be put to productive use in their regular operations. Such marginal resources are often mobilized through networks of social relationships when the resource providers regard a connection to the public event as being valuable. The mobilization of marginal resources is analyzed using a network approach and by analyzing the motives of the participating resource providers. Cases involving two public events are presented in order to illustrate the mobilization and the development of patterns and routines over time. The cases indicate that resources are mainly mobilized through networking. Building and using the legitimacy of the event are important factors in this process. The actors providing resources are motivated by a mix of interests, but most of them have an idealistic interest in the event. The mobilized resources are combined in ways that create economy of scope and scale for the organizer. Over time, a recurring event benefits from experience and learned behavior among the actors involved. It seems to be easier to mobilize resources in a community where the actors, and clusters of actors, are well connected with each other
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