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- Meisner, J., et al.
(författare)
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Intercomparison of reference measuring systems for lightning impulses between three National Metrology Institutes
- 2018
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Ingår i: ICHVE 2018 - 2018 IEEE International Conference on High Voltage Engineering and Application. - 9781538650868
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Konferensbidrag (refereegranskat)abstract
- In one of the largest and most extensive measurement campaigns to date, the measuring systems for lightning impulses (LI) of the National Metrology Institutes (NMIs) of Germany (PTB), Sweden (RISE) and Finland (VTT MIKES) have been compared. In the high-voltage laboratory of PTB, lightning impulse comparisons were carried out at voltages up to 1500 kV. The test voltage, front time, time to half-value and the relative overshoot magnitude of seven systems have been compared. The results confirm the capabilities and uncertainties of the participating metrology institutes and even enable an improvement of those. Finally, the question, whether an uncertainty of less than 0.5 % for peak values and 1 % for time parameters for NMI reference measuring systems for a lightning impulse up to at least 800 kV is achievable, will be addressed.
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- Draxler, K., et al.
(författare)
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Results of an International Comparison of Instrument Current Transformers up to 10 kA at 50 Hz Frequency
- 2018
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Ingår i: CPEM 2018 - Conference on Precision Electromagnetic Measurements. - 9781538609736
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Konferensbidrag (refereegranskat)abstract
- Traceability of the current ratio is crucial for the measurement of electrical energy in revenue metering. A comparison of the AC current ratio was therefore performed within EURAMET in the time period 2012-2016, using a precision CT as the traveling device. The Czech Metrology Institute (CMI) as coordinator processed the measurement results of the 15 European participating laboratories. The comparison of the results for transformer ratios of (4, 5, 6, 8, 10) kA 5 A at 15 VA burden and (4 and 10) kA 5 A ratios at 5 VA burden indicates good agreement between the participating laboratories. The main differences are found for phase displacement, at least in part due to instability of the traveling standard. .
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- Mardinoglu, Adil, 1982, et al.
(författare)
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Personal model-assisted identification of NAD(+) and glutathione metabolism as intervention target in NAFLD
- 2017
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Ingår i: Molecular Systems Biology. - : EMBO. - 1744-4292. ; 13:3
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Tidskriftsartikel (refereegranskat)abstract
- To elucidate the molecular mechanisms underlying non-alcoholic fatty liver disease (NAFLD), we recruited 86 subjects with varying degrees of hepatic steatosis (HS). We obtained experimental data on lipoprotein fluxes and used these individual measurements as personalized constraints of a hepatocyte genome-scale metabolic model to investigate metabolic differences in liver, taking into account its interactions with other tissues. Our systems level analysis predicted an altered demand for NAD(+) and glutathione (GSH) in subjects with high HS. Our analysis and metabolomic measurements showed that plasma levels of glycine, serine, and associated metabolites are negatively correlated with HS, suggesting that these GSH metabolism precursors might be limiting. Quantification of the hepatic expression levels of the associated enzymes further pointed to altered de novo GSH synthesis. To assess the effect of GSH and NAD(+) repletion on the development of NAFLD, we added precursors for GSH and NAD(+) biosynthesis to the Western diet and demonstrated that supplementation prevents HS in mice. In a proof-of-concept human study, we found improved liver function and decreased HS after supplementation with serine (a precursor to glycine) and hereby propose a strategy for NAFLD treatment.
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