| 1. |
- Liffner, Susanne, et al.
(författare)
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Men becoming fathers by intracytoplasmic sperm injection were more often born small for gestational to age
- 2017
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Ingår i: Asian Journal of Andrology. - : MEDKNOW PUBLICATIONS & MEDIA PVT LTD. - 1008-682X .- 1745-7262. ; 19:1, s. 103-106
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Tidskriftsartikel (refereegranskat)abstract
- Being born with nonoptimal birth characteristics decreases the chance of becoming a father. Urogenital malformations as well as metabolic syndrome are more common in men born small for gestational age (SGA) and could be contributing factors to the reduced fertility rate seen in these men. It could imply that men becoming fathers by assisted reproductive technology (ART) more often are born with low birth weight (LBW), preterm, and/or SGA than men conceiving without treatment and also that men where intracytoplasmic sperm injection (ICSI) had to be performed more often are born with nonoptimal birth characteristics than men where conventional in vitro fertilization (IVF) successfully could be used. In this retrospective, case-control study using Swedish national registers, we compared the birth characteristics of 1206 men who have become fathers by ART with a control group consisting of age-matched men who became fathers without treatment. The differences in birth characteristics between men becoming fathers by IVF and ICSI were also assessed. For men becoming fathers by ART, OR of being born with LBW was 1.66 (95% CI = 1.17-2.36) compared with fathers who conceived without treatment. OR of being born prematurely was 1.32 (95% CI = 1.00-1.77). Men becoming fathers via ICSI had a doubled increased likelihood of being born SGA compared with men who became fathers via IVF (OR = 2.12; 95% CI = 1.17-3.83). In conclusion, we have found that men becoming fathers by ICSI treatments had more often been born SGA than men becoming fathers by conventional IVF.
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| 2. |
- Enblom, Anna, et al.
(författare)
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Reduced Need for Rescue Antiemetics and Improved Capacity to Eat in Patients Receiving Acupuncture Compared to Patients Receiving Sham Acupuncture or Standard Care during Radiotherapy
- 2017
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Ingår i: Evidence-Based Complementary and Alternative Medicine. - : Hindawi Limited. - 1741-427X .- 1741-4288.
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Tidskriftsartikel (refereegranskat)abstract
- Objective. To evaluate if consumption of emesis-related care and eating capacity differed between patients receiving verum acupuncture, sham acupuncture, or standard care only during radiotherapy. Methods. Patients were randomized to verum(n = 100) or sham (n = 100) acupuncture (telescopic blunt sham needle) (median 12 sessions) and registered daily their consumption of antiemetics and eating capacity. A standard care group (n = 62) received standard care only and delivered these data once. Results. More patients in the verum (n = 73 of 89 patients still undergoing radiotherapy; 82%, Relative Risk (RR) 1.23, 95% Confidence Interval (CI) 1.01-1.50) and the sham acupuncture group (n = 79 of 95; 83%, RR 1.24, CI 1.03-1.52) did not need any antiemetic medications, as compared to the standard care group (n = 42 out of 63; 67%) after receiving 27 Gray dose of radiotherapy. More patients in the verum (n = 50 of 89; 56%, RR 1.78, CI 1.31-2.42) and the sham acupuncture group (n = 58 of 94 answering patients; 62%, RR 1.83, CI 1.20-2.80) were capable of eating as usual, compared to the standard care group (n = 20 of 63; 39%). Conclusion. Patients receiving acupuncture had lower consumption of antiemetics and better eating capacity than patients receiving standard antiemetic care, plausible by nonspecific effects of the extra care during acupuncture.
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| 3. |
- Hammar, Mats, 1950-, et al.
(författare)
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A long-term follow-up study of men born with very low birth weight and their reproductive hormone profile
- 2018
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Ingår i: Systems biology in reproductive medicine. - : Taylor & Francis. - 1939-6376 .- 1939-6368. ; 64:3, s. 207-215
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Tidskriftsartikel (refereegranskat)abstract
- Environmental factors during the fetal period may adversely affect reproductive functions in men being born with very low birth weight (VLBW, <1500 g). The objective of this prospective, controlled cohort study was to investigate if VLBW men have an altered reproductive hormone profile compared with men born at term. The study group initially consisted of all VLBW boys live-born between 1 February 1987 and 30 April 1988 in the south-east region of Sweden (n = 47). A control child was chosen born at term, at the same hospital, with the same parity, without malformations, and next in order after each VLBW child who survived the first four weeks (n = 45). The present follow-up was performed when the men were 26-28 years of age and included measurements of serum hormone levels, hair testosterone concentration, and anthropometric data. Also life-style questionnaires were collected from 26 VLBW men and 19 controls. The VLBW group (n = 26) had higher median levels of serum estradiol, 84.5 pmol/L than controls (n = 19), 57.5 pmol/L (p = 0.008). There was no significant correlation between serum estradiol and BMI (r = 0.06, p = 0.74). There were no differences in other hormone levels or the reproductive pattern between the groups. In conclusion, even though there was a statistically significant difference in estradiol levels between the groups, both groups had low normal mean levels of questionable clinical significance. The reproductive pattern was similar in the two groups and in this study being born VLBW does not seem to affect these measured aspects of reproduction.ABBREVIATIONS: ADHD: attention deficit hyperactive disorder; AGA: average for gestational age; BMI: body mass index; CP: cerebral palsy; DHT: dihydrotestosterone; FSH: follicle stimulating hormone; LBW: low birth weight; LH: luteinizing hormone; SAD: sagittal abdominal diameter; SGA: small for gestational age; SHBG: sex hormone binding globulin; TSH: thyroid stimulating hormone; T3: triiodothyronine; T4: thyroxin; VLBW: very low birth weight.
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| 4. |
- Malmborg, Agota, et al.
(författare)
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A survey of young women’s perceptions of the influence of the Levonorgestrel-Intrauterine System or copper-intrauterine device on sexual desire
- 2019
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Ingår i: Sexual & Reproductive HealthCare. - : Elsevier. - 1877-5756 .- 1877-5764. ; 21, s. 75-80
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Tidskriftsartikel (refereegranskat)abstract
- Objectives: Few studies, with contradictory results, evaluate intrauterine contraceptives (IUC) and sexual function specifically. This study compares perception of sexual desire related to IUC use and aspects of sexual function in women who use the Lng-IUS with those using the Cu-IUD.Study design: A secondary analysis regarding IUC use based on a larger cross-sectional survey of contraceptive use in Sweden, conducted in 2013. In total, 153 IUC users (103 Cu-IUD and 50 Lng-IUS users) answered the questionnaire. The only inclusion criterion was intrauterine contraceptive use.Main outcome measures: Were self-reported sexual desire changes related to contraceptive method. We also analysed aspects of sexual functioning; sexual desire level, sexual activity, orgasm frequency, satisfaction with sex life and satisfaction of desire level.Results: A negative effect on sexual desire due to contraceptive method was reported by 28% of the Lng-IUS users and by 10.1% of the Cu-IUD users (p < 0.05). Results were more marked after adjusting for age, body mass index, depression, parity, switching behaviour, and partnership (OR 5.0; CI: 1.8-13.8).The adjusted odds of reporting low sexual desire level (never or almost never feeling sexual desire) (OR 3.5; CI: 1.1-11.2) as well as low satisfaction with sex life (OR 2.7; CI: 1.2-6.3) was higher in the Lng-IUS group (adjusted for same confounders as above).Conclusions: The women in this study using the Lng-IUS more often report negative sexual desire effects of their contraception as well as lower sexual desire level compared with women using the Cu-IUD.
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| 5. |
- Malmborg, Agota, 1979-
(författare)
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Happy with the method? : Sexual function changes in young women using contraception
- 2019
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- Background: Sexuality and contraception are closely linked topics. In theory, hormonal contraception use might affect female sexual function in both positive and negative directions. Some women experience and report adverse sexual function changes while they use hormonal contraception while others report no or positive changes. Questions of causality, the potential mechanisms of action, and how to counsel women reporting adverse changes have been a matter of debate but scientific consensus is lacking on the answers.Material and Methods: The first study was a cross-sectional study with 1851 women, aged 22, 25 and 28 years, who answered a questionnaire regarding contraception use, positive and negative side effects, contraceptive counselling, and aspects of sexual function. The second study was a randomised double-blind placebo-controlled multicentre clinical trial. In this study we compared 102 women who used a combined oral contraceptive with 100 women who took placebo, regarding sexual function scores evaluated with the Mc Coy Female Sexuality Questionnaire. We measured testosterone level changes in serum and hair as a secondary outcome. The third study was a qualitative study in which we explored women’s experiences of the negative effects of hormonal contraceptive use on sexual function. We interviewed 24 selected women who had reported previous experiences of adverse sexual function changes while using a hormonal contraceptive method.Results and Conclusions: Young Swedish women who used hormonal contraception, reported a negative change in sexual desire more than twice as often as women who used hormone-free contraceptive methods. A similar difference was seen between users of the levonorgestrel-intrauterine system compared with users of the copper-intrauterine device.The experience of an adverse sexual desire effect, which the women thought was due to contraceptive use, was a strong predictive factor for reconsideration of the contraceptive method.We found no change in the total score of sexual function during the use of a combined oral contraceptive compared with placebo. Sexual interest and lubrication which were two aspects of the total sexual function, were found to be negatively associated with the use of the tested combined oral contraceptive. Changes were small however, and the clinical relevance of these findings is therefore unclear. Furthermore, lubrication change did not persist following adjustment for change in self-rated depression scores.The biologically active fraction of testosterone embedded in hair did not decrease during combined oral contraceptive treatment and no reliable associations were found between the induced serum testosterone level decrease and sexual desire changes. Women reporting negative sexual function effects while using hormonal contraception, described lubrication difficulties and decreased sexual desire associated with both contraceptive use and parts of the menstrual cycle. Associations became obvious with time and experience and consequently contraceptive choice became easier with age, experience, and better understanding, all of which we concluded could be facilitated by a responsive contraceptive counsellor.Our findings indicate the need for further evaluation of sexual function changes in the selected group of women who seem to be susceptible to the use of hormonal contraceptives.
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| 6. |
- Vikström, Josefin, 1984-, et al.
(författare)
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Risk of postnatal depression or suicide after in vitro fertilisation treatment : a nationwide case–control study
- 2017
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Ingår i: British Journal of Obstetrics and Gynecology. - Chichester : Wiley-Blackwell Publishing Inc.. - 1470-0328 .- 1471-0528. ; 124:3, s. 435-442
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveTo examine whether women who undergo in vitro fertilisation (IVF) treatment are at greater risk of postnatal suicide or postnatal depression (PND) requiring psychiatric care, compared with women who conceive spontaneously.DesignCase–control study using data from national registers.SettingSweden during the period 2003–2009.Population Cases were 3532 primiparous women who had given birth following IVF treatment. An aged-matched control group of 8553 mothers was randomly selected from the medical birth register.MethodsLogistic regression analyses were performed with PND as the outcome, and with known risk factors of PND as well as IVF/spontaneous birth as covariates.Main outcome measuresPostnatal depression (PND), defined as diagnoses F32–F39 of the tenth edition of the International Classification of Diseases (ICD–10), within 12 months of childbirth.ResultsInitial analyses showed that PND was more common in the control group than in the IVF group (0.8 versus 0.4%; P = 0.04); however, these differences disappeared when confounding factors were controlled for. A history of any psychiatric illness (P = 0.000; odds ratio, OR = 25.5; 95% confidence interval, 95% CI = 11.7–55.5), any previous affective disorder (P = 0.000; OR = 26.0; 95% CI = 10.5–64.0), or specifically a personality disorder (P = 0.028; OR = 3.8; 95% CI = 1.2–12.7) increased the risk of PND. No woman in either group committed suicide during the first year after childbirth.ConclusionsWhereas mothers who receive IVF treatment are not at increased risk of PND, the risk is increased among mothers with a history of mental illness. Tweetable abstract A Swedish study on 3532 women showed that IVF treatment does not increase the risk of postnatal depression.
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