| 1. |
- Chen, Ruikui, et al.
(författare)
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Photoinduced intramolecular charge-transfer state in thiophene-π-conjugated donor-acceptor molecules.
- 2008
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Ingår i: Journal of Molecular Structure. - : Elsevier BV. - 0022-2860 .- 1872-8014. ; 876:1-3, s. 102-109
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Tidskriftsartikel (refereegranskat)abstract
- Novel thiophene-π-conjugated donor-acceptor mols., 5-[2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)-vinyl]-thiophene-2-carbaldehyde (QTC) and (1-cyano-2-{5-[2-(1,2,2,4-tetramethyl-1,2,3,4-tetrahydroquinolin-6-yl)-vinyl]-thiophen-2-yl}-vinyl)-phosphonic acid di-Et ester (QTCP), were designed and synthesized. Combined exptl. and theor. methods were performed to investigate the photoinduced intramol. charge-transfer (ICT) processes of these compds. Steady-state absorption and fluorescence measurements in different solvents indicate the photoinduced ICT characters of QTC and QTCP. Solvent dependency of the large Stokes shifts and high dipole moment of the excited state also support the charge-transfer character of the excited state. Theor. calcns. based on time-dependent d. functional theory (TDDFT) method were performed to investigate ICT states of these compds. The results reveal that the excited states have adopted a distortion of the C=C double bond between the donor moiety and the thiophene-π-bridge. [on SciFinder(R)]
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| 2. |
- Hua, Dong, et al.
(författare)
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Small interfering RNA-directed targeting of toll-like receptor 4 inhibits human prostate cancer cell invasion, survival, and tumorigenicity
- 2009
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Ingår i: Molecular Immunology. - : Elsevier BV. - 0161-5890 .- 1872-9142. ; 46:15, s. 2876-2884
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Tidskriftsartikel (refereegranskat)abstract
- A major cause of tumor treatment failure is cancer cell metastasis. Toll-like receptor 4 (TLR4)-mediated signaling has been implicated in tumor cell invasion, survival, and metastasis in a variety of cancers. In this study, we investigated the biological roles of TLR4 in prostate metastatic cell invasion and survival, and the potential of gene silencing of TLR4 using small interfering RNA (siRNA) for treatment of cancer. In cultured human prostate cancer cell lines, TLR4 were higher PC3 and DU145 as compared with the poorly metastatic LNCaP indicating that up-regulation of TLR4 was positively correlated with metastasis of tumor cell. In the highly metastatic cancer cell PC3, gene silencing of TLR4 using siRNA significantly inhibited TLR4 mRNA expression and protein level. Knockdown of TLR4 in PC3 cells resulted in a dramatic reduction of tumor cell migration and invasion as indicated by a Matrigel invasion assay. Furthermore, TLR4 siRNA suppressed cell viability and ultimately caused the induction of apoptotic cell death. The effects were associated with abrogating TLR4-mediated signaling to downstream target molecules such as myeloid differentiation factor 88 (MyD88), adaptor-inducing IFN-beta (TRIF), and interferon regulatory factor-1 (IRF-1). In a mouse prostate cancer model, administration with the plasmid construct expressing siRNA for TLR4 obviously inhibited established tumor growth and survival. These studies revealed evidence of a multifaceted signaling network operating downstream of TLR4-mediated tumor cell invasion, proliferation, and survival. Thus, RNA interference-directed targeting of TLR4 may raise the potential of its application for cancer therapy.
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| 3. |
- Pathmasiri, Wimal, et al.
(författare)
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Aryl ketones from Acronychia pedunculata with cyclooxygenase-2 inhibitory effects
- 2005
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Ingår i: Chemistry & biodiversity. - : Wiley. - 1612-1872 .- 1612-1880. ; 2:4, s. 463-469
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Tidskriftsartikel (refereegranskat)abstract
- 1-[2,4-Dihydroxy-6-methoxy-3,5-bis(3-methylbut-2-en-1-yl)phenyl]ethanone (1), and a new aryl ketone, named acrovestenol (2), were isolated as cyclooxygenase-2 (COX-2) inhibitory principles from a CH2Cl2 extract of the bark of Acronychia pedunculata by a bioassay-guided fractionation procedure. Compound 2 inhibited COX-2 with an IC50 value of 142.0+/-2.15 microM, compared to the COX-2 inhibitory reference compound NS-398 with an IC50 value of 11.3+/-1.12 microM. Compound 1 inhibited COX-2-catalyzed PG biosynthesis with 68% at a concentration of 500 microM. The structures were determined by UV, IR, and 1D- and 2D-NMR, including TOCSY, HSQC-DEPT, and HMBC, and MS investigations.
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| 4. |
- Xiao, Huan, et al.
(författare)
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THE STUDY FOR FERROMAGNETIC PROPERTIES AND MICROSTRUCTURE OF Bi(0.9)Ho(0.1)FeO(3)
- 2008
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Ingår i: PROCEEDINGS OF THE 2008 SYMPOSIUM ON PIEZOELECTRICITY, ACOUSTIC WAVES AND DEVICE APPLICATIONS. - : IEEE. - 9781424428915 ; , s. 557-560
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Konferensbidrag (refereegranskat)abstract
- Bi(0.9)Ho(0.1)FeO(3) ceramic is prepared by sol-gel method. We investigated the effect of Ho element doping in the BiFeO(3). We studied the microstructure, morphology and ferromagnetism for Bi(0.9)Ho(0.1)FeO(3) ceramic by XRD, SEM and SQUID. It shows that Bi(0.9)Ho(0.1)FeO(3) ceramic exhibits single phase of perovskite structure. The c/a rate is elevated from 1 to 1.009 with respect to BiFeO(3). The grains of Bi(0.9)Ho(0.1)FeO(3) ceramic shrink sharply compared with the ones of BiFeO(3) ceramic, which is beneficial to the connection between grains and the density. Bi(0.9)Ho(0.1)FeO(3) ceramic exhibits obvious ferromagnetism while BiFeO(3) ceramic does not possess the macroscopic ferromagnetism at the RT. The magnetization sinks in the horizontal direction near the zero magnetic field. It indicates that Bi(0.9)Ho(0.1)FeO(3) ceramics do not only show obvious ferromagnetism, but also could exhibit lower magnetic hysteresis loss.
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