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Träfflista för sökning "WFRF:(Hancock A. D.) srt2:(2005-2009)"

Sökning: WFRF:(Hancock A. D.) > (2005-2009)

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2.
  • Davidson, D. J., et al. (författare)
  • IRAK-4 mutation (Q293X): rapid detection and characterization of defective post-transcriptional TLR/IL-1R responses in human myeloid and non-myeloid cells
  • 2006
  • Ingår i: J Immunol. ; 177:11, s. 8202-11
  • Tidskriftsartikel (refereegranskat)abstract
    • Innate immunodeficiency has recently been reported as resulting from the Q293X IRAK-4 mutation with consequent defective TLR/IL-1R signaling. In this study we report a method for the rapid allele-specific detection of this mutation and demonstrate both cell type specificity and ligand specificity in defective IL-1R-associated kinase (IRAK)-4-deficient cellular responses, indicating differential roles for this protein in human PBMCs and primary dermal fibroblasts and in LPS, IL-1beta, and TNF-alpha signaling. We demonstrate transcriptional and post-transcriptional defects despite NF-kappaB signaling and intact MyD88-independent signaling and propose that dysfunctional complex 1 (IRAK1/TRAF6/TAK1) signaling, as a consequence of IRAK-4 deficiency, generates specific defects in MAPK activation that could underpin this patient's innate immunodeficiency. These studies demonstrate the importance of studying primary human cells bearing a clinically relevant mutation; they underscore the complexity of innate immune signaling and illuminate novel roles for IRAK-4 and the fundamental importance of accessory proinflammatory signaling to normal human innate immune responses and immunodeficiencies.
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3.
  • Pham, M. K., et al. (författare)
  • A new Certified Reference Material for radionuclides in Irish sea sediment (IAEA-385)
  • 2008
  • Ingår i: APPLIED RADIATION AND ISOTOPES. - : Elsevier BV. - 1872-9800 .- 0969-8043. ; 66:11, s. 1711-1717
  • Konferensbidrag (refereegranskat)abstract
    • A new Certified Reference Material (CRM) for radionuclides in sediment (IAEA-385) is described and the results of the certification process are presented. Eleven radionuclides (K-40, Cs-137, Ra-226, Ra-228, Th-230, Th-232, U-234, U-238, Pu-238, Pu239+240 and Am-241) have been certified and information mass activities with 95% confidence intervals are given for seven other radionuclides (Sr-90, Pb-210(Po-210), U-235, Pu-239, Pu-240 and Pu-241). Results for less frequently reported radionuclides (Co-60, Tc-99, Cs-134, Eu-155, Ra-224 and Np-239) and information on some activity and mass ratios are also reported. The CRM can be used for quality assurance/quality control of the analysis of radionuclides in sediment samples, for the development and validation of analytical methods and for training purposes. (C) 2008 IAEA. Published by Elsevier Ltd. All rights reserved.
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4.
  • Gürer, D., et al. (författare)
  • Women in Computing
  • 2009
  • Ingår i: Wiley Encyclopedia of Computer Science and Engineering. - Hoboken, NJ, USA : John Wiley & Sons. - 9780470050118 ; , s. 3099-3122
  • Bokkapitel (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-4 av 4

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