| 1. |
- Andersson, Lena, 1980, et al.
(författare)
-
Urinary proteins in children with urinary tract infection
- 2009
-
Ingår i: Pediatric Nephrology. - : Springer Science and Business Media LLC. - 0931-041X .- 1432-198X. ; 24:8, s. 1533-1538
-
Tidskriftsartikel (refereegranskat)abstract
- Abstract The aim of this study was to test our hypothesis that the urinary excretion of C-reactive protein (CRP), alpha 1-microglobulin (A1M), retinol-binding protein (RBP) and Clara cell protein (CC16) is increased in children with urinary tract infection (UTI) and relates to renal damage as measured by acute dimercaptosuccinic acid (DMSA) scintigraphy. Fifty-two children <2 years of age with UTI were enrolled in the study, 44 of whom were febrile. The control group consisted of 23 patients with non-UTI infection and elevated serum CRP (s-CRP) levels. Thirty-six patients had abnormal DMSA uptake, classified as mild, moderate or severe damage (DMSA class 1, 2, 3, respectively). There was a significant association between DMSA class and the excretion of urinary RBP (u-RBP) and u-CC16. There was also a significant difference in u-CRP levels between children with UTI and control children with non-UTI infections, although u-CRP excretion was not significantly correlated to DMSA class. In conclusion, the urinary excretion of the low-molecular-weight proteins RBP and CC16 showed a strong association with uptake defects on renal DMSA scans. The urinary level of CRP seems to distinguish between children with UTI and other febrile conditions. A combination of these biomarkers may be useful in the clinical assessment of children with UTI.
|
|
| 2. |
|
|
| 3. |
|
|
| 4. |
- Bohgard, Mats, et al.
(författare)
-
Pedagogisk förändring av arbetsvetenskapskurser i några olika utbildningsprogram vid LTH
- 2003
-
Ingår i: Pedagogisk inspirationskonferens LTH 27 maj 2003. - Lund : Lunds tekniska högskola, Lunds universitet. ; , s. 14-17
-
Konferensbidrag (refereegranskat)abstract
- Vi har genomfört genomgripande förändringar i obligatoriska grundkurser i arbetsvetenskap. Förändringarna har genomförts som en utvecklingsprocess i vilken samtliga lärare som deltagit i kurserna har medverkat. Processen startade med konsulthjälp från Universitetspedagogiskt centrum vid Lunds universitet, fortsatte med kompetensutveckling av oss själva och följdes av några utvecklingsprojekt, varefter från grunden förändrade kurser genomfördes under fyra år. Den nya uppläggningen medförde att vi fick positiva attityder i studentenkäterna när det gällde två av kurserna i årskurs 2 i vilken medodiken genomfördes fullständigt. I en kurs, som gavs i årskurs 1 och i vilken den nya uppläggningen endast delvis genomfördes blev studentattityderna negativa.
|
|
| 5. |
- Engström, Tomas, et al.
(författare)
-
Process Oriented Ergonomics - The Ergonomics of the Future? A Case Study of Integrated Ergonomics at an Engine Assembly Plant
- 2000
-
Ingår i: Proceedings of the IEA 2000/HFES 2000 Congress. ; 5, s. 5-331
-
Konferensbidrag (refereegranskat)abstract
- Ergonomics are, in most cases, focusing on the human being when evaluating assembly system designs. This results in the human performance being expressed isolated from the technical environment. On the other hand, technicians are prone to concentrate on the hardware. These conditions underline the need to pursue a more integrated evaluation and design procedure in order to avoid the drawbacks of these traditional approaches. In this paper, the authors propose an alternative approach, i.e. process oriented ergonomics, which might be a constructive way of tackling some of the more complex aspects of the man-machine interaction in industrial environments such as assembly of engines.
|
|
| 6. |
- Landin-Wilhelmsen, Kerstin, 1952, et al.
(författare)
-
Spontaneous pregnancies in a Turner syndrome woman with Y-chromosome mosaicism.
- 2004
-
Ingår i: Journal of assisted reproduction and genetics. - 1058-0468. ; 21:6, s. 229-30
-
Tidskriftsartikel (refereegranskat)abstract
- PURPOSE: To present a case involving pregnancies in a Turner woman with Y-chromosome mosaicism. METHOD: A descriptive case report of a single patient. RESULTS: A 39-year-old woman was admitted to the endocrine clinic due to fatigue and premature menopause. She had tried in-vitro fertilization and oocyte donation twice without pregnancies but became spontaneously pregnant at age 36 and 37 and delivered two girls. During the seventh month of the second pregnancy, a dissecting aortic aneurysm, a coarctation, and subsequently a pheochromocytoma were detected and repaired. Hypothyroidism developed. Turner syndrome was diagnosed. Fluorescence in situ hybridization (FISH) analysis of lymphocytes revealed 31% XY cells and 4% XYY cells, while 66% of buccal cells had an XY constitution. Oophorectomy revealed no malignancy. FISH revealed 54% XY cells in the left gonad and 38% XY cells in the right. CONCLUSION: Turner syndrome should be suspected in women with aortic dissection, in general, but especially in those with additional features such as horseshoe kidney, coarctation, and infertility.
|
|
| 7. |
|
|
| 8. |
|
|
| 9. |
- Vuong, Mai Tuyet, et al.
(författare)
-
Genetic variation in the transforming growth factor-beta1 gene is associated with susceptibility to IgA nephropathy
- 2009
-
Ingår i: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. - : Oxford University Press (OUP). - 1460-2385 .- 0931-0509. ; 24:10, s. 3061-7
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: There is growing evidence of genetic risk for susceptibility to IgA nephropathy. Among several candidate genes related to immunological regulation in renal tissue, TGFB1 is known to be a contributor to proliferation and the development of fibrosis. METHODS: We analysed several SNPs in a region of this gene using 212 DNA samples from biopsy-proven IgA nephropathy patients, 146 men and 66 women and 477 healthy age-matched controls (321 men and 156 women) from the same population in Sweden. RESULTS: Frequencies of four out of five selected SNPs (rs6957, rs2241715, rs1800471, rs1982073 and rs1800469) were found to significantly differ between male patients and male controls in a co-dominant model (corrected P
|
|
| 10. |
- Allard, Per, et al.
(författare)
-
Efficacy and tolerability of venlafaxine in geriatric outpatients with major depression : a double-blind, randomised 6-month comparative trial with citalopram.
- 2004
-
Ingår i: International Journal of Geriatric Psychiatry. - : Wiley. - 0885-6230 .- 1099-1166. ; 19:12, s. 1123-30
-
Tidskriftsartikel (refereegranskat)abstract
- BACKGROUND: The objectives of the study were to compare efficacy and tolerability of venlafaxine ER 75-150 mg/day with that of citalopram 10-20 mg/day in elderly patients with major depression according to DSM-IV criteria. METHODS: A randomised, double-blind, parallel group 6-month study. Efficacy was assessed by MADRS, CGI Global Improvement, CGI Severity of Illness and GDS-20 scores and safety by physical examinations, vital signs, adverse events and UKU side effect rating. Plasma levels of venlafaxine, its major metabolite O-desmethylvenlafaxine and citalopram were followed. RESULTS: One hundred and fifty-one male and female patients (64-89 years) were enrolled and 118 patients completed the study. Comparable improvements in MADRS, CGI Severity of Illness, CGI Global Improvement and GDS-20 were observed during venlafaxine and citalopram treatment. The MADRS remission rate was 19% for venlafaxine and 23% for citalopram. Side effects were common during both treatments but differed in tremor being more common during citalopram and nausea/vomiting during venlafaxine treatment. There were no clinically significant changes in blood pressure or body weight. CONCLUSION: The observed benefits of venlafaxine treatment in elderly patients with major depression were similar to those observed in younger adults as were reported adverse events and side effects. Treatment with venlafaxine ER was well tolerated and induced beneficial effects of similar magnitude as those of citalopram.
|
|
