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- Ravi Sharma, Dulal, 1987, et al.
(författare)
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Human Milk: Its Components and Their Immunobiologic Functions
- 2015
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Ingår i: Mucosal Immunology: Fourth Edition. Volume 2. - : Elsevier. - 9780124158474 ; , s. 2307-2341
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Whereas a neonate is born is sterile, immediate exposure to its mother's mucosal surfaces allows it to acquire microflora, which plays an important role in defense against potential pathogens. This initial stimulus helps the immature immune system of the newborn to develop the capacity to respond with specific immunologic tolerance while avoiding the development of allergic and autoimmune disease. Breast-feeding provides nutritional and developmental, along with anti-infectious, advantages to the infant. The significant protection conferred by breast-feeding against varied infections such as acute and prolonged diarrhea, neonatal septicemia, respiratory tract infections, acute and recurrent otitis media, and urinary tract infections is observed worldwide. Human breast milk contains numerous components, including antibodies, cytokines, hormones, enzymes, and major proteins with multiple activities (microbicidal, tumoricidal, anti-inflammatory, autoimmune, etc.). Breast-feeding can strikingly reduce infant mortality, as well as the fertility of the breast-feeding mother. In this manner, breast-feeding provides significant benefits for lactating mothers and their offspring, in addition to society as a whole. © 2015 Elsevier Inc. All rights reserved.
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| 2. |
- Zaman, S., et al.
(författare)
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High doses of Antisecretory Factor stop diarrhea fast without recurrence for six weeks post treatment
- 2018
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Ingår i: International Journal of Infectious Diseases. - : Elsevier BV. - 1201-9712. ; 71, s. 48-52
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Tidskriftsartikel (refereegranskat)abstract
- Background: Diarrheal illnesses in young children cause morbidity and preventable deaths in developing countries. We evaluated two high doses of Salovum (R) [Antisecretory Factor] to treat diarrhea in young children and followed up for recurrence 6 weeks post treatment. Methods: Forty children, 6-24 months old, admitted with acute diarrhea, to the Outpatient Department of Children's Hospital in Lahore, Pakistan were selected. The patients were randomly allocated to either Group A given 2 sachets, or to Group B, given 4 sachets. Each sachet contained 4 gram of Salovum (R) and was mixed with Oral Rehydration Salt solution. This mixture was administered perorally within the first 30 min of treatment. The trained nursing staff observed them for number of stools and consistency over every half hour for a total of 4 hours. Follow up for 6 weeks was done daily by telephone, or visits by the mothers. The results demonstrate that Salovum (R) provides a protective effect irrespective of the diarrhea causes. Results: Group B, given 4 sachets of Salovum (R) showed improved fecal consistency in 80% of the children compared to 50% in Group A within 30 minutes of treatment, p= 0.004. The number of diarrheal stools decreased over this time from seven to one/two over 4 hours in the two groups [p = 0.234]. None of the children showed a recurrence of diarrhea over the follow up period. Conclusion: Peroral high doses of Salovum (R) rapidly and safely counteract diarrhea in children followed by a diarrhea-free period of 6 weeks. (C) 2018 The Authors. Published by Elsevier Ltd on behalf of International Society for Infectious Diseases.
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