| 1. |
- Golman, Klaes, et al.
(författare)
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13C-angiography.
- 2002
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Ingår i: Academic Radiology. - 1878-4046. ; 9:Suppl 2, s. 507-510
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Tidskriftsartikel (refereegranskat)
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| 2. |
- Forslund, Ola, et al.
(författare)
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Population-based type-specific prevalence of high-risk human papillomavirus infection in middle-aged Swedish Women.
- 2002
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Ingår i: Journal of Medical Virology. - : Wiley. - 1096-9071 .- 0146-6615. ; 66:4, s. 535-541
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Tidskriftsartikel (refereegranskat)abstract
- Human papillomavirus (HPV) DNA testing can be used to identify women at risk of the development of cervical cancer. The cost-effectiveness of HPV screening is dependent on the type-specific HPV prevalence in the general population. The present study describes the prevalence and spectrum of high-risk HPV types found in a large real-life population-based HPV screening trial undertaken entirely within the cervical screening program offered to middle-aged Swedish women. Cervical brush samples from 6,123 women aged 32-38 years were analyzed using a general HPV primer (GP5(+)/6(+)) polymerase chain reaction-enzyme immunoassay (PCR-EIA) combined with reverse dot-blot hybridization for confirmation and HPV typing by a single assay. In this study, 6.8% (95% CI 6.2-7.5) (417/6,123) were confirmed as high-risk HPV positive. Infections with 13 different high-risk HPV types were detected, of which HPV 16 was the most prevalent type (2.1%; 128/6,123), followed by HPV 31 (1.1%; 67/6,123). Any one of the HPV types 18, 33, 35, 39, 45, 51, 52, 56, 58, 59, or 66 was detected in 3.6% (223/6,123) of the women. Infection with two, three, and five types simultaneously was identified in 32, 5, and 1 women, respectively. The combination of PCR-EIA as a screening test and reverse dot-blot hybridization as a confirmatory test, was found to be readily applicable to a real-life population-based cervical screening. The type-specific HPV prevalence found support in previous modeling studies suggesting that HPV screening may be a favorable cervical screening strategy.
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| 3. |
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| 4. |
- Antonsson, Annika, et al.
(författare)
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Healthy skin of many animal species harbors papillomaviruses which are closely related to their human counterparts.
- 2002
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Ingår i: Journal of Virology. - 1098-5514. ; 76:24, s. 12537-12542
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Tidskriftsartikel (refereegranskat)abstract
- Papillomaviruses associated with clinical symptoms have been found in many vertebrate species. In this study, we have used an L1 gene consensus PCR test designed to detect a broad spectrum of human skin papillomaviruses to analyze swab samples from healthy skin of 111 animals belonging to 19 vertebrate species. In eight of the species, papillomavirus DNA was found with the following prevalences: chimpanzees, 9 of 11 samples positive; gorillas, 3 of 4; long-tailed macaques, 14 of 16; spider monkeys, 2 of 2; ruffed lemurs, 1 of 2; cows, 6 of 10; European elks, 4 of 4; aurochs, 1 of 1. In total, 53 new putative animal papillomavirus types were found. The results show that skin papillomaviruses can be detected in healthy skin from many different animal species and are sufficiently related genetically to their human counterparts to be identified by a human skin papillomavirus primer set (FAP59 and FAP64).
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| 5. |
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| 6. |
- Antonsson, Annika, et al.
(författare)
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Prevalence and type spectrum of human papillomaviruses in healthy skin samples collected in three continents.
- 2003
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Ingår i: Journal of General Virology. - : Microbiology Society. - 1465-2099 .- 0022-1317. ; 84:Pt 7, s. 1881-1886
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Tidskriftsartikel (refereegranskat)abstract
- In order to investigate whether previous findings of ubiquitous skin papillomavirus infection in Caucasians apply to populations from other parts of the world, skin swab samples from Bangladesh, Japan, Ethiopia and Zambia were analysed in parallel with Swedish samples. The prevalence of HPV DNA in the material from Bangladesh was 68 %, Japan 54 %, Ethiopia 52 %, Zambia 42 % and Sweden 70 %. A great multiplicity of genotypes was demonstrated by the finding of 88 HPV types or putative types in 142 HPV DNA-positive samples in total. Double or multiple genotypes were frequently found in the same sample. The most prevalent HPV type was HPV-5, with an overall prevalence of 6·5 %. This was also the only type that was found in samples from all of the countries in the study. The results presented show that commensal skin HPV infections have a worldwide distribution with a very broad spectrum of genotypes.
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| 7. |
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| 8. |
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| 9. |
- Bengtsson, Göran, et al.
(författare)
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Reduced grazing rates in Daphnia pulex caused by contaminants: Implications for trophic cascades
- 2004
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Ingår i: Environmental Toxicology and Chemistry. - : Wiley. - 0730-7268 .- 1552-8618. ; 23:11, s. 2641-2648
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Tidskriftsartikel (refereegranskat)abstract
- Ecotoxicological endpoints based on behavioral traits (e.g., predator avoidance, feeding, and locomotion) may be more sensitive and give more insights into patterns of sublethal toxicity than survivorship tests. In this study, the density-dependent grazing rate of Daphnia pulex pre-exposed to p,p'-dichlorodiphenyldichloroethylene (DDE) (insecticide metabolite) and glyphosate (herbicide), via water or a vector, Scenedesmus spp., was assayed in laboratory experiments. The phytoplankton biomass was estimated from the chlorophyll content, and the pesticide uptake and turnover pattern in Daphnia and Scenedestnus were determined from parallel experiments with a radiolabeled source. Scenedestnus spp. relative net growth rate was inversely and linearly related to the density of the grazer. Daphnia pulex exhibited significant reductions in grazing rate: 30% for those pre-exposed to p,p'DDE via water and 40% for D. pulex pre-exposed to glyphosate via Scenedesmus spp. Through the process of trophic cascading, this impaired grazing allowed Scenedesmus spp. to grow at higher rates, 70 and 60%, respectively. The reduced grazing efficiencies were associated with the treatments that gave the highest body burden of p,p'-DDE (70 mug/g dry wt) and the lowest of glyphosate (13 mg/g dry wt). The pattern of results suggests a toxic effect of p,p'-DDE on D. pulex and a growth enhancement of Scenedesmus spp. in response to nitrogen and phosphorus in glyphosate excreted by D. pulex.
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| 10. |
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