| 1. |
- Andersson, Christian X, 1973, et al.
(författare)
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Shedding and gamma-Secretase mediated intramembrane proteolysis of the mucin-type molecule CD43
- 2005
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Ingår i: Biochem J.. ; 387:2, s. 377-384
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Tidskriftsartikel (refereegranskat)abstract
- CD43 is a transmembrane molecule that contains a 123-aminoacids-long cytoplasmic tail and a highly O-glycosylated extracellular domain of mucin type. Endogenous CD43 expressed in COLO 205, K562 and Jurkat cells revealed a membrane-associated, 20 kDa CD43-specific cytoplasmic tail fragment (CD43-CTF) upon inhibition of gamma-secretase. This fragment was formed by an extracellular cleavage, as it was not accumulated after treating cells with 1,10-phenanthroline, a metalloprotease inhibitor. When CD43 was transfected into HEK-293 cells expressing dominant-negative PS1 (presenilin-1), the CD43-CTF was accumulated, but not in cells with wild-type PS1. Owing to its accumulation in the presence of a non-functional PS variant, it may thus be a novel gamma-secretase substrate. This CTF is formed by an extracellular cleavage close to the membrane, is a fragment that can be concluded to be a substrate for gamma-secretase. However, the intracellular gamma-secretase product has not been possible to detect, suggesting a quick processing of this product. During normal growth the CTF was not found without gamma-secretase inhibition, but when the cells (COLO 205) were very confluent the fragment could be detected. The intracellular domain of CD43 has previously been shown to contain a functional nuclear localization signal, and has been suggested to be involved in gene activation. From this and the present results, a novel way to explain how mucin-type molecules may transduce intracellular signals can be proposed.
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| 2. |
- Azar, Christian, 1969, et al.
(författare)
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Brazilian Ethanol has the Edge.
- 2007
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Ingår i: Financial Times.
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)
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| 3. |
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| 4. |
- Berndes, Göran, 1966, et al.
(författare)
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Bioenergy expansion in the EU: Cost-effective climate change mitigation, employment creation and reduced dependency on imported fuels
- 2007
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Ingår i: Energy Policy. - : Elsevier BV. - 0301-4215. ; 35:12, s. 5965-5979
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Tidskriftsartikel (refereegranskat)abstract
- Presently, the European Union (EU) is promoting bioenergy. The aim of this paper is to study the prospects for using domestic biomass resources in Europe and specifically to investigate whether different policy objectives underlying the promotion of bioenergy (cost-effective climate change mitigation, employment creation and reduced dependency on imported fuels) agree on which bioenergy options that should be used. We model bioenergy use from a cost-effectiveness perspective with a linear regionalized energy- andtransport-system model and perform supplementary analysis. It is found that the different policy objectives do not agree on the order of priority among bioenergy options. Maximizing climate benefits cost-effectively is in conflict with maximizing employment creation. The former perspective proposes the use of lignocellulosic biomass in the stationary sector, while the latter requires biofuels for transport based on traditional agricultural crops. Further, from a security-of-supply perspective, the appeal of a given bioenergy option depends on how oil and gas import dependencies are weighed relative to each other. Consequently, there are tradeoffs that need to be addressed by policymakers promoting the use of bioenergy. Also, the importance of bioenergy in relation to employment creation and fuel import dependency reduction needs to be further addressed.
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| 5. |
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| 6. |
- Berndes, Göran, 1966, et al.
(författare)
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Biomassa - en knapp resurs i globalt perspektiv
- 2007
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Ingår i: Bioenergi - till vad och hur mycket?. ; :Formas Fokuserar, s. 19-32
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Bokkapitel (övrigt vetenskapligt/konstnärligt)abstract
- Idag använder vi ungefär tio gånger mer fossil energi än bioenergi i världen. Nu ökar användningen av bioenergi kraftigt. Men globalt sett finns det inte tillräckligt med bioenergi för att ersätta de fossila bränslena, skriver tre forskare på Chalmers. Hur ska vi använda de knappa resurserna på bästa sätt? Och hur ska vi kunna begränsa de negativa effekter som ökad efterfrågan på bioenergi kan få? Det handlar bland annat om exploatering av värdefulla ekosystem som regnskogar.
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| 7. |
- Berndes, Göran, 1966, et al.
(författare)
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Expanding sugarcane ethanol production in Brazil - Socioeconomic and climate effects of expanding sugarcane ethanol production in the Pontal do Paranapanema region (State of São Paulo, Brazil)
- 2007
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Ingår i: Proceedings of the 15th European Biomass Conference & Exhibition - From research to market Deployment, Berlin, Germany, 7-11 May 2007.
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Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- This paper presents results from a study of socioeconomic and climate effects connected to a sugarcane expansion scenario in the Pontal do Paranapanema region, São Paulo state, Brazil. Sugarcane production is expected to grow in the São Paulo state. Pontal do Paranapanema is the only region in the state where a large scale sugarcane expansion can take place and there is a concern that without guidelines the expansion might affect income growth in a negative way. A scenario where the settlers in the region gain from the sugarcane expansion was modelled. The models showed that it is possible to introduce sugarcane in the region with positive effects both on income growth and greenhouse gas emissions.
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| 8. |
- Bishop, D. Timothy, et al.
(författare)
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Genome-wide association study identifies three loci associated with melanoma risk
- 2009
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 41:8, s. 920-925
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Tidskriftsartikel (refereegranskat)abstract
- We report a genome-wide association study of melanoma conducted by the GenoMEL consortium based on 317K tagging SNPs for 1,650 selected cases and 4,336 controls, with replication in an additional two cohorts (1,149 selected cases and 964 controls from GenoMEL, and a population-based case-control study in Leeds of 1,163 cases and 903 controls). The genome-wide screen identified five loci with genotyped or imputed SNPs reaching P < 5 x 10(-7). Three of these loci were replicated: 16q24 encompassing MC1R (combined P = 2.54 x 10(-27) for rs258322), 11q14-q21 encompassing TYR (P = 2.41 x 10(-14) for rs1393350) and 9p21 adjacent to MTAP and flanking CDKN2A (P = 4.03 x 10(-7) for rs7023329). MC1R and TYR are associated with pigmentation, freckling and cutaneous sun sensitivity, well-recognized melanoma risk factors. Common variants within the 9p21 locus have not previously been associated with melanoma. Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
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| 9. |
- Brown, Kevin M., et al.
(författare)
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Common sequence variants on 20q11.22 confer melanoma susceptibility
- 2008
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 40:7, s. 838-840
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Tidskriftsartikel (refereegranskat)abstract
- We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases.
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| 10. |
- Egeskog, Andrea, 1981, et al.
(författare)
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Co-generation of biofuels for transportation and heat for district heating systems – an assessment of the national possibilities in the EU
- 2009
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Ingår i: Energy Policy. - Amsterdam : Elsevier BV. - 0301-4215 .- 1873-6777. ; 37:12, s. 5260-5272
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Tidskriftsartikel (refereegranskat)abstract
- Biomass gasification with subsequent synthesis to liquid or gaseous biofuels generates heat possible to use in district heating (DH) systems. The purpose here is to estimate the heat sink capacity of DH systems in the individual EU nations and assess the possibilities for biomass-gasification-based co-generation of synthetic biofuels for transportation and heat (CBH) for DH systems in the EU countries. The possibilities are assessed (i) assuming different levels of competiveness relative to other heat supply options of CBH corresponding to the EU target for renewable energy for transportation for 2020 and (ii) assuming that the potential expansion of the DH systems by 2020 is met with CBH. In general, the size of the DH heat sinks represented by the existing national aggregated DH systems can accommodate CBH at a scale that is significant compared to the 2020 renewable transportation target. The possibilities for CBH also depend on its cost-competitiveness compared to, e.g., fossil-fuel-based CHP. The possible expansion of the DH systems by 2020 represents an important opportunity for CBH and is also influenced by the potential increase in the use of other heat supply options, such as, industrial waste heat, waste incineration, and CHP.
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