| 1. |
- Humar, Miha, et al.
(författare)
-
Introduction of the COST FP 1303 Cooperative Performance Test
- 2015
-
Ingår i: Proceedings of the 46th IRG Annual Meeting.
-
Konferensbidrag (refereegranskat)abstract
- COST Action FP 1303 “Performance of bio-based building materials” successfully started in October 2013 and an ambitious program was set up for the four year programme. COST Actions provide an excellent opportunity for collaborative research, e.g. in the frame of Round Robin tests.The idea of this respective test was to distribute a fairly simple test set up to as many places in Europe as possible in order to collect performance data reflecting the range of climatic exposure conditions. Furthermore we wanted to consider performance in its manifold meaning, i.e. optical, aesthetical, moisture and functional performance and durability. In contrast to traditional Round Robin tests aiming on comparative evaluation and validation of results from different test laboratories, this initiative aims on collecting performance data under climatically different exposure conditions. Therefore it was required to provide weather data from the respective test sites to allow establishing relationships between climate conditions and the following measured, which shall be evaluated regularly: decay, discolouration, development of mould and other staining fungi, corrosion, formation of cracks and moisture performance (if data logging device is included). Further details about the test and the first outcomes are presented in this paper.
|
|
| 2. |
- Mitchell, Jonathan S., et al.
(författare)
-
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma
- 2016
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 7
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P = 1.31 x 10(-8)), 6q21 (rs9372120, P = 9.09 x 10(-15)), 7q36.1 (rs7781265, P = 9.71 x 10(-9)), 8q24.21 (rs1948915, P = 4.20 x 10(-11)), 9p21.3 (rs2811710, P = 1.72 x 10(-13)), 10p12.1 (rs2790457, P = 1.77 x 10(-8)), 16q23.1 (rs7193541, P = 5.00 x 10(-12)) and 20q13.13 (rs6066835, P = 1.36 x 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development.
|
|
| 3. |
- Pettersson, Fredrik, et al.
(författare)
-
Exploring the collaborative toolbox for the public transport sector – guidelines and living labs as informal methods for achieving efficient collaboration
- 2017
-
Konferensbidrag (övrigt vetenskapligt/konstnärligt)abstract
- The purpose of the paper is to analyse informal collaboration in the public transport sector. Two Swedish case studies Living lab Uddevalla and Guidelines for Regional BRT are analysed and compared concerning what kind of learning occurred and what lessons regarding informal collaboration to draw from the two cases. For both cases the analysis indicates that individual, single loop learning is the most striking type of learning among the participants. The voluntary approach of the two cases has advantages and drawbacks. Advantages include that participants were truly interested in the issues of collaboration, which created energy and contributed to building trust. The main drawback identified was that in both cases the voluntary enthusiasm of the participants collided with the formal requirements of planning and decision making. This has stifled the possibility of the informal collaboration processes to induce change in prevailing practices.
|
|
| 4. |
- Pettersson, Fredrik, et al.
(författare)
-
Learning through collaboration in the Swedish public transport sector? Co-production through guidelines and living labs
- 2018
-
Ingår i: Research in Transportation Economics. - : Elsevier BV. - 0739-8859 .- 1875-7979. ; 69, s. 394-401
-
Tidskriftsartikel (refereegranskat)abstract
- The purpose of the paper is to analyse informal collaboration in the public transport sector. Two Swedish case studies, Living lab Uddevalla and Guidelines for Regional BRT are analysed and compared concerning what kind of learning occurred and what lessons regarding informal collaboration to draw from the two cases. For both cases the analysis indicates that individual, single loop learning is the most striking type of learning among the participants. The voluntary approach of the two cases has advantages and drawbacks. Advantages include that participants were truly interested in the issues of collaboration, which created energy and contributed to building trust. The main drawback identified was that in both cases the voluntary enthusiasm of the participants collided with the formal requirements of planning and decision making. This has stifled the possibility of the informal collaboration processes to induce change in prevailing practices.
|
|
| 5. |
- Swaminathan, Bhairavi, et al.
(författare)
-
Variants in ELL2 influencing immunoglobulin levels associate with multiple myeloma.
- 2015
-
Ingår i: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 6, s. 1-8
-
Tidskriftsartikel (refereegranskat)abstract
- Multiple myeloma (MM) is characterized by an uninhibited, clonal growth of plasma cells. While first-degree relatives of patients with MM show an increased risk of MM, the genetic basis of inherited MM susceptibility is incompletely understood. Here we report a genome-wide association study in the Nordic region identifying a novel MM risk locus at ELL2 (rs56219066T; odds ratio (OR)=1.25; P=9.6 × 10(-10)). This gene encodes a stoichiometrically limiting component of the super-elongation complex that drives secretory-specific immunoglobulin mRNA production and transcriptional regulation in plasma cells. We find that the MM risk allele harbours a Thr298Ala missense variant in an ELL2 domain required for transcription elongation. Consistent with a hypomorphic effect, we find that the MM risk allele also associates with reduced levels of immunoglobulin A (IgA) and G (IgG) in healthy subjects (P=8.6 × 10(-9) and P=6.4 × 10(-3), respectively) and, potentially, with an increased risk of bacterial meningitis (OR=1.30; P=0.0024).
|
|
