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Role of Surface Che...
Role of Surface Chemistry in the In Vitro Lung Response to Nanofibrillated Cellulose
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- Aimonen, Kukka (författare)
- Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland.
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- Suhonen, Satu (författare)
- Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland.
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- Hartikainen, Mira (författare)
- Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland.
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- Lopes, Viviana (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Norppa, Hannu (författare)
- Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland.
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- Ferraz, Natalia, 1976- (författare)
- Uppsala universitet,Nanoteknologi och funktionella material
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- Catalan, Julia (författare)
- Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland.;Univ Zaragoza, Dept Anat Embryol & Genet, Zaragoza 50013, Spain.
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Finnish Inst Occupat Hlth, Box 40, Helsinki 00032, Finland Nanoteknologi och funktionella material (creator_code:org_t)
- 2021-02-03
- 2021
- Engelska.
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Ingår i: Nanomaterials. - : MDPI. - 2079-4991. ; 11:2
- Relaterad länk:
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https://doi.org/10.3...
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https://uu.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://urn.kb.se/re...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Wood-derived nanofibrillated cellulose (NFC) has emerged as a sustainable material with a wide range of applications and increasing presence in the market. Surface charges are introduced during the preparation of NFC to facilitate the defibrillation process, which may also alter the toxicological properties of NFC. In the present study, we examined the in vitro toxicity of NFCs with five surface chemistries: nonfunctionalized, carboxymethylated, phosphorylated, sulfoethylated, and hydroxypropyltrimethylammonium-substituted. The NFC samples were characterized for surface functional group density, surface charge, and fiber morphology. Fibril aggregates predominated in the nonfunctionalized NFC, while individual nanofibrils were observed in the functionalized NFCs. Differences in surface group density among the functionalized NFCs were reflected in the fiber thickness of these samples. In human bronchial epithelial (BEAS-2B) cells, all NFCs showed low cytotoxicity (CellTiter-GloVR luminescent cell viability assay) which never exceeded 10% at any exposure time. None of the NFCs induced genotoxic effects, as evaluated by the alkaline comet assay and the cytokinesis-block micronucleus assay. The nonfunctionalized and carboxymethylated NFCs were able to increase intracellular reactive oxygen species (ROS) formation (chloromethyl derivative of 2 ',7 '-dichlorodihydrofluorescein diacetate assay). However, ROS induction did not result in increased DNA or chromosome damage.
Ämnesord
- NATURVETENSKAP -- Kemi -- Materialkemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Materials Chemistry (hsv//eng)
Nyckelord
- nanofibrillated cellulose
- surface chemistry
- genotoxicity
- nanotoxicity
- nanocellulose
- reactive oxygen species
- human bronchial epithelial cells
- Teknisk fysik med inriktning mot nanoteknologi och funktionella material
- Engineering Science with specialization in Nanotechnology and Functional Materials
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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