| 1. |
- Almén, Edgar, 1943-, et al.
(author)
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Livstolkning och värdegrund : att undervisa om religion, livsfrågor och etik
- 2000
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Book (other academic/artistic)abstract
- Skolans värdegrund har på senare år lyfts fram i många olika sammanhang. Uppgiften att undervisa om religion, etik, och livsfrågor har också debatterats. Detta undervisningsområde hör till skolans svåraste uppgifter - men kanske också till de viktigaste. Denna antologi ger ett bidrag till utvecklingen av ett professionellt lärarkunnande i frågor som gäller skolans värdegrund och undervisning på livsåskådningsområdet.Författarna ger utifrån sina respektive kompetensområden en belysning av några av ämnesområdets centrala aspekter.De texter som ingår har skrivits särskilt för lärarutbildningen men kan också användas i andra sammanhang. Avsikten har varit att via texterna föra de studerande i kontakt med såväl aktuell forskning som professionell lärarkunskap av annat slag.
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| 2. |
- Frazier-Wood, Alexis C., et al.
(author)
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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
- 2016
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In: Nature Genetics. - : Nature Research (part of Springer Nature). - 1061-4036 .- 1546-1718. ; 48, s. 624-
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Journal article (peer-reviewed)abstract
- Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (vertical bar(p) over cap vertical bar approximate to 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
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| 3. |
- Gatchell, Michael, et al.
(author)
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Commissioning of the DESIREE storage rings - a new facility for cold ion-ion collisions
- 2014
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In: XXVIII International Conference on Photonic, Electronic and Atomic Collisions (ICPEAC 2013). - : Institute of Physics (IOP). ; 488:1
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Conference paper (peer-reviewed)abstract
- We report on the ongoing commissioning of the Double ElectroStatic Ion Ring ExpEriment, DESIREE, at Stockholm University. Beams of atomic carbon anions (C-) and smaller carbon anion molecules (C-2(-), C-3(-), C-4(-) etc.) have been produced in a sputter ion source, accelerated to 10 keV or 20 keV, and stored successfully in the two electrostatic rings. The rings are enclosed in a common vacuum chamber cooled to below 13 Kelvin. The DESIREE facility allows for studies of internally relaxed single isolated atomic, molecular and cluster ions and for collision experiments between cat-and anions down to very low center-of-mass collision energies (meV scale). The total thermal load of the vacuum chamber at this temperature is measured to be 32 W. The decay rates of stored ion beams have two components: a non-exponential component caused by the space charge of the beam itself which dominates at early times and an exponential term from the neutralization of the beam in collisions with residual gas at later times. The residual gas limited storage lifetime of carbon anions in the symmetric ring is over seven minutes while the 1/e lifetime in the asymmetric ring is measured to be about 30 seconds. Although we aim to improve the storage in the second ring, the number of stored ions are now sufficient for many merged beams experiments with positive and negative ions requiring milliseconds to seconds ion storage.
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| 4. |
- Hartman, Henrik, et al.
(author)
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First storage of ion beams in the Double Electrostatic Ion-Ring Experiment : DESIREE
- 2013
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In: Review of Scientific Instruments. - : American Institute of Physics (AIP). - 0034-6748 .- 1089-7623. ; 84:5
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Journal article (peer-reviewed)abstract
- We report on the first storage of ion beams in the Double ElectroStatic Ion Ring ExpEriment, DESIREE, at Stockholm University. We have produced beams of atomic carbon anions and small carbon anion molecules (Cn-, n = 1, 2, 3, 4) in a sputter ion source. The ion beams were accelerated to 10 keV kinetic energy and stored in an electrostatic ion storage ring enclosed in a vacuum chamber at 13 K. For 10 keV C2- molecular anions we measure the residual-gas limited beam storage lifetime to be 448 s +/- 18 s with two independent detector systems. Using the measured storage lifetimes we estimate that the residual gas pressure is in the 10-14 mbar range. When high current ion beams are injected, the number of stored particles does not follow a single exponential decay law as would be expected for stored particles lost solely due to electron detachment in collision with the residual-gas. Instead, we observe a faster initial decay rate, which we ascribe to the effect of the space charge of the ion beam on the storage capacity.
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| 5. |
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| 6. |
- Hibar, Derrek P., et al.
(author)
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Novel genetic loci associated with hippocampal volume
- 2017
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In: Nature Communications. - : Springer Science and Business Media LLC. - 2041-1723. ; 8
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Journal article (peer-reviewed)abstract
- The hippocampal formation is a brain structure integrally involved in episodic memory, spatial navigation, cognition and stress responsiveness. Structural abnormalities in hippocampal volume and shape are found in several common neuropsychiatric disorders. To identify the genetic underpinnings of hippocampal structure here we perform a genome-wide association study (GWAS) of 33,536 individuals and discover six independent loci significantly associated with hippocampal volume, four of them novel. Of the novel loci, three lie within genes (ASTN2, DPP4 and MAST4) and one is found 200 kb upstream of SHH. A hippocampal subfield analysis shows that a locus within the MSRB3 gene shows evidence of a localized effect along the dentate gyrus, subiculum, CA1 and fissure. Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g) = -0.155). Our findings suggest novel biological pathways through which human genetic variation influences hippocampal volume and risk for neuropsychiatric illness.
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| 7. |
- Satizabal, Claudia L., et al.
(author)
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Genetic architecture of subcortical brain structures in 38,851 individuals
- 2019
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In: Nature Genetics. - : Nature Publishing Group. - 1061-4036 .- 1546-1718. ; 51:11, s. 1624-
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Journal article (peer-reviewed)abstract
- Subcortical brain structures are integral to motion, consciousness, emotions and learning. We identified common genetic variation related to the volumes of the nucleus accumbens, amygdala, brainstem, caudate nucleus, globus pallidus, putamen and thalamus, using genome-wide association analyses in almost 40,000 individuals from CHARGE, ENIGMA and UK Biobank. We show that variability in subcortical volumes is heritable, and identify 48 significantly associated loci (40 novel at the time of analysis). Annotation of these loci by utilizing gene expression, methylation and neuropathological data identified 199 genes putatively implicated in neurodevelopment, synaptic signaling, axonal transport, apoptosis, inflammation/infection and susceptibility to neurological disorders. This set of genes is significantly enriched for Drosophila orthologs associated with neurodevelopmental phenotypes, suggesting evolutionarily conserved mechanisms. Our findings uncover novel biology and potential drug targets underlying brain development and disease.
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| 8. |
- Thomas, Richard D., et al.
(author)
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DESIREE : Physics with cold stored ion beams
- 2015
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In: DR2013. - : EDP Sciences. ; 84, s. 01004-01004
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Conference paper (peer-reviewed)abstract
- Here we will briefly describe the commissioning of the Double ElectroStatic Ion Ring ExpEriment (DESIREE) facility at Stockholm University, Sweden. This device uses purely electrostatic focussing and deflection elements and allows ion beams of opposite charge to be confined under extreme high vacuum and cryogenic conditions in separate rings and then merged over a common straight section. This apparatus allows for studies of interactions between cations and anions at very low and well-defined centre-of-mass energies (down to a few meV) and at very low internal temperatures (down to a few K).
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| 9. |
- Almén, Edgar, 1943-, et al.
(author)
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Att undervisa om religion, livsfrågor och etik i skolan
- 1994
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Book (other academic/artistic)abstract
- Att undervisa om religion, etik och livsfrågor hör till skolans svåraste uppgifter. Den här antologin är ett bidrag till utvecklingen av ett professionellt lärarkunnande i frågor som gäller skolans undervisning på livsåskådningsområdet. Texterna har skrivits särskilt för lärarutbildningen. Författarna är erfarna pedagoger verksamma inom lärarutbildningen
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| 10. |
- Brockstedt, Håkan, 1927-
(author)
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Slagsta skola och seminarium och dess föregångare : skolan för sinnesslöa barn i Stockholm : ideologi och praktik i undervisningen av barn med utvecklingsstörning 1870-1950
- 2000
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Doctoral thesis (other academic/artistic)abstract
- This is a pedagogical-historical thesis. The sources were some guides for teacher training, curricula and pictures. The latter show learning settings and materials for sensory training which were considered important in developing the children's senses, since it was supposed that sensory dysfunction constituted the retardation.In Sweden, the education of mentally retarded children started in the 1860s.Initially philanthropic, soon the county councils took interest in the work. By the end of the century, institutions had grown up in most of the counties, but the philanthropic institutions continued their work for a long time.As far as education went, a school run by The Society for the Care of Mentally Retarded Children in Stockholm became the most important. This school, the first one in Sweden, was founded in 1870. In 1879 a teacher training college was connected to it. Teaching methods were developed and through teachers trained at the college the methods were spread out of the country. Parallel to, or even somewhat earlier than these schools, institutions for other groups of handicapped children, deaf-mute and blind, were founded. The education of "abnormal" people was used as a common concept for these schools.An important point concerning the School for Mentally Retarded was the board's efforts to find the best leaders and the best teachers, the most important being the headmistress Thorborg Rappe and the female psychiatrist Alfhild Tamm. In contrast to the common practice in other European countries of engaging male physicians and priests as principals for the institutions, in Sweden it became a task for pedagogically trained women. In 1911 the school in Stockholm was replaced by a new institution in the countryside about 20 kilometres south of Stockholm. That institution adopted the name Slagsta skola och seminarium (The Slagsta School and Teacher-training College).The education of the mentally retarded took inspiration from schools on the continent, especially the French ones. There, the two physicians Itard and Séguin, had developed programmes for the training of the motor and sensory functions. At this time it was supposed that retardation was due to disturbances in the sensory organs.A second characteristic of the Slagsta method was all-encompassing education. This meant that studies over a period of time were concentrated on a special subject. There was no talk of a curriculum as in general education. While studying the subject the pupils used their abilities in reading, writing, counting, modelling, etc.The Slagsta skola och seminarium was run by the Society until 1950. From 1951 the school belonged to Stockholm County. The teacher training activities continued for some years, but in 1959 were replaced by a new organisation for the training of teachers in special education.
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