| 1. |
- Noterdaeme, J. M., et al.
(författare)
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Heating, current drive and energetic particle studies on JET in preparation of ITER operation
- 2003
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Ingår i: Nuclear Fusion. - : IOP Publishing. - 0029-5515 .- 1741-4326. ; 43:3, s. 202-209
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Tidskriftsartikel (refereegranskat)abstract
- This paper summarizes the recent work on JET in the three areas of heating, current drive and energetic particles. The achievements have extended the possibilities of JET, have a direct connection to ITER operation and provide new and interesting physics. Toroidal rotation profiles of plasmas heated far off axis with little or no refuelling or momentum input are hollow with only small differences on whether the power deposition is located on the low field side or on the high field side. With LH current drive the magnetic shear was varied from slightly positive to negative. The improved coupling (through the use of plasma shaping and CD4) allowed up to 3.4 MW of PLH in internal transport barrier (ITB) plasmas with more than 15 MW of combined NBI and ICRF heating. The q-profile with negative magnetic shear and the ITB could be maintained for the duration of the high heating pulse (8 s). Fast ions have been produced in JET with ICRF to simulate alpha particles: by using third harmonic He-4 heating, beam injected He-4 at 120 kV were accelerated to energies above 2 MeV taking advantage of the unique capability of JET to use NBI with 4 He and to confine MeV class ions. ICRF heating was used to replicate the dynamics of alpha heating and the control of an equivalent Q = 10 `burn' was simulated.
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| 2. |
- Terazono, Y., et al.
(författare)
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Photonic control of photoinduced electron transfer via switching of redox potentials in a photochromic moiety
- 2004
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Ingår i: Journal of Physical Chemistry B. ; 108:6, s. 1812-1814
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Tidskriftsartikel (refereegranskat)abstract
- A porphyrin (P) has been covalently linked to a photochromic dihydroindolizine moiety (DHI) to form a P-DHI dyad. When the dihydroindolizine is in its closed, spirocyclic form (DHIc), the photophysics of the attached porphyrin are unaffected. Irradiation with UV light opens the photochromic moiety to the betaine form (DHIo), which has a significantly higher reduction potential than DHIc. Light absorption by the porphyrin moiety of P-DHIo is followed by rapid (50 ps) photoinduced electron transfer to yield the P.+-DHIo(.-) charge-seperated state. This state recombines in 2.9 ps to give the ground state. Irradiation of P-DHIo with light at wavelengths > 590 nm induces photoisomerization back to P-DHIc. Thermal closing can also be achieved. Thus, light is used to switch photoinduced electron transfer on or off. These principles may be useful in the design of molecular optoelectronic devices.
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| 3. |
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| 4. |
- Holdaas, H., et al.
(författare)
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Effect of fluvastatin on cardiac outcomes in renal transplant recipients : A multicentre, randomised, placebo-controlled trial
- 2003
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Ingår i: The Lancet. - 0140-6736 .- 1474-547X. ; 361:9374, s. 2024-2031
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Tidskriftsartikel (refereegranskat)abstract
- Background: Renal transplant recipients are at increased risk of premature cardiovascular disease. Although statins reduce cardiovascular risk in the general population, their efficacy and safety in renal transplant recipients have not been established. We investigated the effects of fluvastatin on cardiac and renal endpoints in this population. Methods: We did a multicentre, randomised, double-blind, placebo-controlled trial in 2102 renal transplant recipients with total cholesterol 4·0-9·0 mmol/L. We randomly assigned patients fluvastatin (n=1050) or placebo (n=1052) and follow up was for 5-6 years. The primary endpoint was the occurrence of a major adverse cardiac event, defined as cardiac death, non-fatal myocardial infarction (MI), or coronary intervention procedure. Secondary endpoints were individual cardiac events, combined cardiac death or non-fatal MI, cerebrovascular events, non-cardiovascular death, all-cause mortality, and graft loss or doubling of serum creatinine. Analysis was by intention to treat. Findings: After a mean follow-up of 5·1 years, fluvastatin lowered LDL cholesterol concentrations by 32%. Risk reduction with fluvastatin for the primary endpoint (risk ratio 0·83 [95% CI 0·64-1·06], p=0·139) was not significant, although there were fewer cardiac deaths or non-fatal MI (70 vs 104, 0·65 [0·48-0·88] p=0·005) in the fluvastatin group than in the placebo group. Coronary intervention procedures and other secondary endpoints did not differ significantly between groups. Interpretation: Although cardiac deaths and non-fatal MI seemed to be reduced, fluvastatin did not generally reduce rates of coronary intervention procedures or mortality. Overall effects of fluvastatin were similar to those of statins in other populations.
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| 5. |
- Schreier, E, et al.
(författare)
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Internal fields in magnetically ordered dysprosium, holmium and erbium
- 2000
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Ingår i: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 289, s. 240-243
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Tidskriftsartikel (refereegranskat)abstract
- Muon spin rotation data on single-crystalline samples of the heavy rare earth metals Dy, Ho and Er have been obtained as function of temperature in both the antiferromagnetic (afm) and the ferromagnetic (fm) state. In the afm state the temperature depende
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| 6. |
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| 7. |
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| 8. |
- Kalvius, GM, et al.
(författare)
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High pressure mu SR studies: rare earths and related materials
- 2000
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Ingår i: HYPERFINE INTERACTIONS. - : BALTZER SCI PUBL BV. - 0304-3843. ; 128:1-3, s. 275-303
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Tidskriftsartikel (refereegranskat)abstract
- After a short introduction to mu SR with respect to the study of magnetic properties, followed by a brief outline of the principle of the high pressure-low temperature mu SR spectrometer installed at the Paul Scherrer Institute, we discuss some measuremen
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| 9. |
- Martin, EM, et al.
(författare)
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Magnetic properties of GdMn2 from mu SR
- 2000
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Ingår i: PHYSICA B. - : ELSEVIER SCIENCE BV. - 0921-4526. ; 289, s. 265-268
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Tidskriftsartikel (refereegranskat)abstract
- GdMn2 has a Neel transition around 100 K and a second magnetic transition near 40 K, which is considered a Curie point. The mu SR data show that both the Gd and the Mn sublattice order at T-N, in contrast to a published model. Using the signal from muons
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| 10. |
- Meri, T, et al.
(författare)
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The hyphal and yeast forms of Candida albicans bind the complement regulator C4b-binding
- 2004
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Ingår i: Infection and Immunity. - 1098-5522. ; 72:11, s. 6633-6641
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Tidskriftsartikel (refereegranskat)abstract
- Candida albicans, an important pathogenic yeast, activates all three pathways of the complement system. To understand how this yeast evades the effects of the activated system, we have analyzed the binding of the classical pathway inhibitor C4b-binding protein (C4BP) by C. albicans. Purified native as well as recombinant C4BP bound dose dependently to the yeast and hyphal forms, as shown by multiple methods, such as confocal microscopy, flow cytometry, a novel enzyme-linked immunosorbent assay, absorption from human serum, and direct binding assays with purified proteins. A prominent binding site was identified at the tip of the germ tube, a structure that is considered important for tissue penetration and pathogenesis. The binding site in C4BP was localized to the two N-terminal complement control protein domains by using recombinant deletion constructs and site-specific monoclonal antibodies. As the alternative pathway inhibitors factor H and FHL-1 also bind to C. albicans, the binding of all three plasma proteins was compared. Simultaneous binding of the classical regulator C4BP and the alternative pathway regulator factor H was demonstrated by confocal microscopy. In addition, FHL-1 competed for binding with C4BP, suggesting that these two related complement regulators bind to the same structures on the yeast surface. The surface-attached C4BP maintains its complement regulatory activities and inactivates C4b. The surface-attached human C4BP serves multiple functions relevant for immune evasion and likely pathogenicity. It inhibits complement activation at the yeast surface and, in addition, mediates adhesion of C. albicans to host endothelial cells.
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