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- Chatterjee, Saion, et al.
(författare)
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Type 2 Diabetes as a Risk Factor for Dementia in Women Compared With Men: A Pooled Analysis of 2.3 Million People Comprising More Than 100,000 Cases of Dementia
- 2016
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Ingår i: Diabetes Care. - : American Diabetes Association. - 0149-5992 .- 1935-5548. ; 39:2, s. 300-307
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE Type 2 diabetes confers a greater excess risk of cardiovascular disease in women than in men. Diabetes is also a risk factor for dementia, but whether the association is similar in women and men remains unknown. We performed a meta-analysis of unpublished data to estimate the sex-specific relationship between women and men with diabetes with incident dementia. RESEARCH DESIGN AND METHODS A systematic search identified studies published prior to November 2014 that had reported on the prospective association between diabetes and dementia. Study authors contributed unpublished sex-specific relative risks (RRs) and 95% CIs on the association between diabetes and all dementia and its subtypes. Sex-specific RRs and the women-to-men ratio of RRs (RRRs) were pooled using random-effects meta-analyses. RESULTS Study-level data from 14 studies, 2,310,330 individuals, and 102,174 dementia case patients were included. In multiple-adjusted analyses, diabetes was associated with a 60% increased risk of any dementia in both sexes (women: pooled RR 1.62 [95% CI 1.45–1.80]; men: pooled RR 1.58 [95% CI 1.38–1.81]). The diabetes-associated RRs for vascular dementia were 2.34 (95% CI 1.86–2.94) in women and 1.73 (95% CI 1.61–1.85) in men, and for nonvascular dementia the RRs were 1.53 (95% CI 1.35–1.73) in women and 1.49 (95% CI 1.31–1.69) in men. Overall, women with diabetes had a 19% greater risk for the development of vascular dementia than men (multiple-adjusted RRR 1.19 [95% CI 1.08–1.30]; P < 0.001). CONCLUSIONS Individuals with type 2 diabetes are at ∼60% greater risk for the development of dementia compared with those without diabetes. For vascular dementia, but not for nonvascular dementia, the additional risk is greater in women.
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| 3. |
- Hassing, Linda, 1967
(författare)
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Light alcohol consumption does not protect cognitive function: A longitudinal prospective study
- 2018
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Ingår i: Frontiers in Aging Neuroscience. - : Frontiers Media SA. - 1663-4365. ; 10:March
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Tidskriftsartikel (refereegranskat)abstract
- Studies show that light to moderate alcohol consumption is related to better health and higher cognitive performance. However, it has been suggested that this association is caused by a systematic bias in the control group as many people abstain from drinking or quit because of health issues. Therefore, the group of non-drinkers is biased towards poor health and may not be suitable as a control group. The present study examined the effect of alcohol on cognitive performance while addressing this bias by excluding the non-drinkers. Thus, instead of comparing different levels of alcohol consumption to a non-drinking control group, a dose-response association was calculated between all levels of alcohol intake and cognitive performance. The study used information from a sample of people in the Swedish Twin Registry, who in their midlife (1967) participated in a survey on alcohol intake and 25 years later participated in a longitudinal study on cognitive aging (N = 486). The cognitive aging study took place on five occasions, at 2-year intervals, and included the Mini Mental State Examination (MMSE), tests of episodic memory, semantic memory and spatial ability. The association between midlife alcohol consumption and later cognitive performance was analyzed using growth curve models, adjusting for background variables. The findings showed that there was a significant negative dose-response association between alcohol intake in midlife and the MMSE, and the tests of episodic memory, such that higher intake in midlife was related to lower performance in old age. The associations between alcohol and semantic memory, and spatial ability respectively, were not significant. In contrast to findings from other studies, which show that low to moderate alcohol intake promotes cognitive function, the current study showed that alcohol intake was related to lower cognitive performance in a dose-response manner, even at low levels. The results from this study indicate that the observed benefits of moderate alcohol intake for cognitive function reported by others might be solely due to comparisons to an inappropriate control group, a group that is biased towards poor health. Hence, it is concluded that light alcohol intake may not protect cognitive function. © 2018 Hassing.
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| 5. |
- Kelly, A., et al.
(författare)
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Independent and Interactive Impacts of Hypertension and Diabetes Mellitus on Verbal Memory: A Coordinated Analysis of Longitudinal Data From England, Sweden, and the United States
- 2016
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Ingår i: Psychology and Aging. - : American Psychological Association (APA). - 0882-7974 .- 1939-1498. ; 31:3, s. 262-273
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Tidskriftsartikel (refereegranskat)abstract
- The importance of preventing and controlling hypertension (HTN) and diabetes mellitus (DM) to mitigate risks to physical health has long been understood by health care professionals. More recently, a growing body of evidence implicates HTN and DM in age-related cognitive decline and risk for dementia, though consensus has yet to be reached on whether older adults living with comorbid HTN and DM are at heightened risk for cognitive impairment. The present study sought to contribute to this topic through a coordinated analysis of 3 longitudinal studies of aging from England, Sweden, and the United States (total N = 12,513). Identical multilevel linear growth models were fit to each to estimate the impact of baseline disease status on initial level and change in verbal declarative memory performance. Overall, few associations between HTN, DM, and cognition were observed. Rate of decline was steeper for Swedish participants with independent HTN but attenuated for their American counterparts. Americans with comorbid HTN and DM showed attenuated decline. Treatment with medication was substantially less prevalent in the earlier-born and lower-educated Swedish sample, which may help to explain our pattern of results. In addition, those living with multiple conditions may be more likely to receive treatment, mitigating cognitive decline. Our results present a nuanced view of the interactions between HTN, DM, and cognition, and lead us to recommend consideration of treatment status or proxies such as birth cohort and education, in combination with age at assessment and specific measure used to interpret research in this area.
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| 6. |
- Lindwall, Magnus, 1975, et al.
(författare)
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Psychological health in the retirement transition: Rationale and first findings in the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study
- 2017
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Ingår i: Frontiers in Psychology. - : Frontiers Media SA. - 1664-1078. ; 8
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Tidskriftsartikel (refereegranskat)abstract
- © 2017 Lindwall, Berg, Bjälkebring, Buratti, Hansson, Hassing, Henning, Kivi, König, Thorvaldsson and Johansson. From an aging research and life-course perspective, the transition to retirement marks a significant life-event and provides a unique opportunity to study psychological health and coping during a period of substantial change in everyday life. The aim of the present paper is to: (a) outline the rationale of the HEalth, Ageing and Retirement Transitions in Sweden (HEARTS) study, (b) describe the study sample, and (c) to present some initial results from the two first waves regarding the association between retirement status and psychological health. The HEARTS study is designed to annually study psychological health in the years before and following retirement, and to examine change and stability patterns related to the retirement event. Among a representative Swedish population-based sample of 14,990 individuals aged 60-66 years, 5,913 completed the baseline questionnaire in 2015. The majority of the participants (69%) completed a web-based survey, and the rest (31%) completed a paper version. The baseline HEARTS sample represents the general population well in terms of gender and age, but is more highly educated. Cross-sectional findings from the first wave showed that retired individuals demonstrated better psychological health compared to those who were still working. Longitudinal results from the first and second waves showed that individuals who retired between waves showed more positive changes in psychological health compared with those still working or previously retired.
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| 7. |
- Praetorius Björk, Marcus, 1982, et al.
(författare)
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I forgot when I lost my grip - Strong associations between cognition and grip strength in level of performance and change across time in relation to impending death
- 2016
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 38, s. 68-72
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Tidskriftsartikel (refereegranskat)abstract
- An association between level of cognitive function and grip strength is well established while evidence for longitudinal associations of change in the two functions is still unclear. We examined associations between cognition and grip strength in levels of performance and in longitudinal change in late life in a population-based sample, aged 80 years and older at baseline, followed until death. The sample consisted of 449 non-demented individuals drawn from the OCTO-twin study. A test battery assessing 6 cognitive domains and grip strength was administered at five occasions with measurements intervals of two years. We fitted time to death bivariate growth curve models, adjusted for age, education and sex which resulted in associations between grip strength and cognition in both levels of performance (across all cognitive domains) and rates of change (in four out of six domains). These results show that cognition and grip strength change conjointly in later life and that the association between cognition and grip strength is stronger prior to death than earlier in life.
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| 9. |
- Zulka, Linn Elena, 1992, et al.
(författare)
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Impact of Retirement on Cognitive Function - A Literature Review
- 2019
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Ingår i: GeroPsych - The Journal of Gerontopsychology and Geriatric Psychiatry. - : Hogrefe Publishing Group. - 1662-9647 .- 1662-971X. ; 32:4, s. 187-203
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Tidskriftsartikel (refereegranskat)abstract
- This article reviews the literature and aims at identifying patterns of findings regarding the impact of retirement on cognitive function. A systematic literature search following the PRISMA statement resulted in discovering 20 studies with longitudinal designs. The results revealed negative, null, and positive associations between retirement and cognition. The conflicting results could not be explained by variations in study characteristics (study quality, operationalization of retirement, analytical approach) or cognitive abilities. However, in studies in which occupational experiences were included as a moderator, there was a positive trend for cognitive functioning when retiring from physically demanding jobs. To gain insight into mechanisms behind the relationship between retirement and cognitive functioning, study designs need to take into account the impact of preretirement factors.
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