| 1. |
- Weinstein, John N., et al.
(författare)
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The cancer genome atlas pan-cancer analysis project
- 2013
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Ingår i: Nature Genetics. - : Springer Science and Business Media LLC. - 1546-1718 .- 1061-4036. ; 45:10, s. 1113-1120
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Tidskriftsartikel (refereegranskat)abstract
- The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels. The resulting rich data provide a major opportunity to develop an integrated picture of commonalities, differences and emergent themes across tumor lineages. The Pan-Cancer initiative compares the first 12 tumor types profiled by TCGA. Analysis of the molecular aberrations and their functional roles across tumor types will teach us how to extend therapies effective in one cancer type to others with a similar genomic profile. © 2013 Nature America, Inc. All rights reserved.
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| 2. |
- Adamo, Angela, et al.
(författare)
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Super star clusters in Haro 11: properties of a very young starburst and evidence for a near-infrared flux excess
- 2010
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 407:2, s. 870-890
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Tidskriftsartikel (refereegranskat)abstract
- We have used multiband imaging to investigate the nature of an extreme starburst environment in the nearby Lyman break galaxy analogue Haro 11 (ESO350-IG038) by means of its stellar cluster population. The central starburst region has been observed in eight different high-resolution Hubble Space Telescope (HST) wavebands, sampling the stellar and gas components from UV to near-infrared. Photometric imaging of the galaxy was also carried out at 2.16μm by NaCo AO instrument at the ESO Very Large Telescope. We constructed integrated spectral energy distributions (SEDs) for about 200 star clusters located in the active star-forming regions and compared them with single stellar population models (suitable for physical properties of very young cluster population) in order to derive ages, masses and extinctions of the star clusters. The cluster age distribution we recover confirms that the present starburst has lasted for 40Myr, and shows a peak of cluster formation only 3.5 Myr old. With such an extremely young cluster population, Haro 11 represents a unique opportunity to investigate the youngest phase of the cluster formation process and evolution in starburst systems. We looked for possible relations between cluster ages, extinctions and masses. Extinction tends to diminish as a function of the cluster age, but the spread is large and reaches the highest dispersion for clusters in partial embedded phases (<5Myr). A fraction of low-mass (below 104 Msolar), very young (1-3Myr) clusters is missing, either because they are embedded in the parental molecular cloud and heavily extinguished, or because of blending with neighbouring clusters. The range of the cluster masses is wide; we observe that more than 30 per cent of the clusters have masses above 105 Msolar, qualifying them as super star clusters. Almost half of the cluster sample is affected by flux excesses at wavelengths >8000Å which cannot be explained by simple stellar evolutionary models. Fitting SED models over all wavebands leads to systematic overestimates of cluster ages and incorrect masses for the stellar population supplying the light in these clusters. We show that the red excess affects also the HST F814W filter, which is typically used to constrain cluster physical properties. The clusters which show the red excess are younger than 40Myr we discuss possible physical explanations for the phenomenon. Finally, we estimate that Haro 11 has produced bound clusters at a rate almost a factor of 10 higher than the massive and regular spirals, like the Milky Way. The present cluster formation efficiency is ~38 per cent of the galactic star formation rate.
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| 3. |
- Adamo, Angela, et al.
(författare)
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The Extremely Young Star Cluster Population In Haro 11
- 2010
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Ingår i: Galaxy Wars. - San Francisco : Astronomical Society of the Pacific. - 9781583817261 ; , s. 74-
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Konferensbidrag (refereegranskat)abstract
- We have performed a deep multi-band photometric analysis of the star cluster population of Haro 11. This starburst galaxy (log L_FUV = 10.3 L_sun) is considered a nearby analogue of Lyman break galaxies (LBGs) at high redshift. The study of the numerous star clusters in the systems is an effective way to investigate the formation and evolution of the starburst phase. In fact, the SED fitting models have revealed a surprisingly young star cluster population, with ages between 0.5 and 40 Myr, and estimated masses between 10^3 and 10^7 solar masses. An independent age estimation has been done with the EW(Halpha) analysis of each cluster. This last analysis has confirmed the young ages of the clusters. We noticed that the clusters with ages between 1 and 10 Myr show a flux excess in H (NIC3/F160W) and/or I (WFPC2/F814W) bands with respect to the evolutionary models. Once more Haro 11 represents a challenge to our understanding.
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| 4. |
- Adamo, Angela, et al.
(författare)
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The Massive Star Clusters in the Dwarf Merger ESO 185-IG13 : is the Red Excess Ubiquitous in Starbursts?
- 2011
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Ingår i: Monthly notices of the Royal Astronomical Society. - : Oxford University Press (OUP). - 0035-8711 .- 1365-2966. ; 414:3, s. 1793-1812
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Tidskriftsartikel (övrigt vetenskapligt/konstnärligt)abstract
- We have investigated the starburst properties of the luminous blue compact galaxy ESO 185-IG13. The galaxy has been imaged with the high resolution cameras onboard to the Hubble Space Telescope. From the UV to the IR, the data reveal a system shaped by hundreds of young star clusters, and fine structures, like a tidal stream and a shell. The presence of numerous clusters and the perturbed morphology indicate that the galaxy has been involved in a recent merger event. Using previous simulations of shell formation in galaxy mergers we constrain potential progenitors of ESO 185-IG13. The analysis of the star cluster population is used to investigate the properties of the present starburst and to date the final merger event, which has produced hundreds of clusters younger than 100 Myr. We have found a peak of cluster formation only 3.5 Myr old. A large fraction of these clusters will not survive after 10-20 Myr, due to the "infant mortality" caused by gas expulsion. However, this sample of clusters represents an unique chance to investigate the youngest phases of cluster evolution. As already observed in the analog blue compact galaxy Haro 11, a fraction of young clusters are affected by a flux excess at wavelengths longer than 8000 \AA. Ages, masses, and extinctions of clusters with this NIR excess are estimated from UV and optical data. We discuss similarities and differences of the observed NIR excess in ESO 185-IG13 clusters with other cases in the literature. The cluster ages and masses are used to distinguish among the potential causes of the excess. We observe, as in Haro 11, that the use of the IR and the (commonly used) I band data results in overestimates of age and mass in clusters affected by the NIR excess. This has important implications for a number of related studies of star clusters.
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| 5. |
- Atek, Hakim, et al.
(författare)
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Influence of physical galaxy properties on Ly alpha escape in star-forming galaxies
- 2014
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Ingår i: Astronomy and Astrophysics. - : EDP Sciences. - 0004-6361 .- 1432-0746. ; 561, s. A89-
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Tidskriftsartikel (refereegranskat)abstract
- Context. Among the different observational techniques used to select high-redshift galaxies, the hydrogen recombination line Lyman-alpha (Ly alpha) is of particular interest because it gives access to the measurement of cosmological quantities such as the star formation rate (SFR) of distant galaxy populations. However, interpreting this line and calibrating such observables are still subject to serious uncertainties. Aims. In this context, it important to understand the mechanisms responsible for the attenuation of Ly alpha emission, and under what conditions the Ly alpha emission line can be used as a reliable star formation diagnostic tool. Methods. We used a sample of 24 Ly alpha emitters at z similar to 0.3 with an optical spectroscopic follow-up to calculate the Ly alpha escape fraction and its dependence upon different physical properties. We also examined the reliability of Ly alpha as a SFR indicator. We combined these observations with a compilation of Ly alpha emitters selected at z = 0-0.3 from the literature to assemble a larger sample. Results. We confirm that the Ly alpha escape fraction clearly depends on the dust extinction following the relation f(esc)(Ly alpha) = C-Ly alpha x 10(-0.4 E(B-V) kLy alpha) where k(Ly alpha) similar to 6.67 and C-Ly alpha = 0.22. However, the correlation does not follow the expected curve for a simple dust attenuation. A higher attenuation can be attributed to a scattering process, while f(esc)(Ly alpha) values that are clearly above the continuum extinction curve can be the result of various mechanisms that can lead to an enhancement of the Ly alpha output. We also observe that the strength of Ly alpha and the escape fraction appear unrelated to the galaxy metallicity. Regarding the reliability of Ly alpha as a SFR indicator, we show that the deviation of SFR(Ly alpha) from the true SFR (as traced by the UV continuum) is a function of the observed SFR(UV), which can be seen as the decrease in f(esc)(Ly alpha) with increasing UV luminosity. Moreover, we observe redshift dependence of this relationship, revealing the underlying evolution of f(esc)(Ly alpha) with redshift.
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| 6. |
- Campbell, Matthew P, et al.
(författare)
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Toolboxes for a standardised and systematic study of glycans
- 2014
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Ingår i: BMC Bioinformatics. - 1471-2105. ; 15:Suppl. 1
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Tidskriftsartikel (refereegranskat)abstract
- Abstract Background Recent progress in method development for characterising the branched structures of complex carbohydrates has now enabled higher throughput technology. Automation of structure analysis then calls for software development since adding meaning to large data collections in reasonable time requires corresponding bioinformatics methods and tools. Current glycobioinformatics resources do cover information on the structure and function of glycans, their interaction with proteins or their enzymatic synthesis. However, this information is partial, scattered and often difficult to find to for non-glycobiologists. Methods Following our diagnosis of the causes of the slow development of glycobioinformatics, we review the "objective" difficulties encountered in defining adequate formats for representing complex entities and developing efficient analysis software. Results Various solutions already implemented and strategies defined to bridge glycobiology with different fields and integrate the heterogeneous glyco-related information are presented. Conclusions Despite the initial stage of our integrative efforts, this paper highlights the rapid expansion of glycomics, the validity of existing resources and the bright future of glycobioinformatics.
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| 7. |
- Hayes, Matthew, et al.
(författare)
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Escape of about five per cent of Lyman-alpha photons from high-redshift star-forming galaxies
- 2010
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Ingår i: Nature. - : Springer Science and Business Media LLC. - 0028-0836 .- 1476-4687. ; 464:7288, s. 562-565
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Tidskriftsartikel (refereegranskat)abstract
- The Lyman-alpha (Ly alpha) emission line is the primary observational signature of star-forming galaxies at the highest redshifts(1), and has enabled the compilation of large samples of galaxies with which to study cosmic evolution(2-5). The resonant nature of the line, however, means that Ly alpha photons scatter in the neutral interstellar medium of their host galaxies, and their sensitivity to absorption by interstellar dust may therefore be greatly enhanced. This implies that the Ly alpha luminosity may be significantly reduced, or even completely suppressed. Hitherto, no unbiased empirical test of the escaping fraction (f(esc)) of Ly alpha photons has been performed at high redshifts. Here we report that the average f(esc) from star-forming galaxies at redshift z=2.2 is just 5 per cent by performing a blind narrowband survey in Ly alpha and H alpha. This implies that numerous conclusions based on Ly alpha-selected samples will require upwards revision by an order of magnitude and we provide a benchmark for this revision. We demonstrate that almost 90 per cent of star-forming galaxies emit insufficient Ly alpha to be detected by standard selection criteria(2-5). Both samples show an anti-correlation of f(esc) with dust content, and we show that Ly alpha- and H alpha-selection recovers populations that differ substantially in dust content and f(esc).
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| 8. |
- Hayes, Matthew, et al.
(författare)
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ON THE REDSHIFT EVOLUTION OF THE Ly alpha ESCAPE FRACTION AND THE DUST CONTENT OF GALAXIES
- 2011
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 730:1, s. 8-
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Tidskriftsartikel (refereegranskat)abstract
- The Ly alpha emission line has been proven to be a powerful tool for studying evolving galaxies at the highest redshift. However, in order to use Ly alpha as a physical probe of galaxies, it becomes vital to know the Ly alpha escape fraction (f(esc)(Ly alpha)). Unfortunately, due to the resonant nature of Ly alpha, f(esc)(Ly alpha) may vary unpredictably and requires empirical measurement. Here, we compile Ly alpha luminosity functions (LFs) between redshifts z = 0 and 8 and, combined with Ha and ultraviolet data, assess how f(esc)(Ly alpha) evolves with redshift. We find a strong upward evolution in f(esc)(Ly alpha) over the range z = 0.3-6, which is well fit by the power law f(esc)(Ly alpha) proportional to (1 + z)(xi) with xi = (2.57(-0.12)(+0.19)). This predicts that f(esc)(Ly alpha) should reach unity at z = 11.1. By comparing f(esc)(Ly alpha) and E(B-V) in individual galaxies we derive an empirical relationship between f(esc)(Ly alpha) and E(B-V), which includes resonance scattering and can explain the redshift evolution of f(esc)(Ly alpha) between z = 0 and 6 purely as a function of the evolution in the dust content of galaxies. Beyond z approximate to 6.5, f(esc)(Ly alpha) drops more substantially, an effect attributed to either ionizing photon leakage, or an increase in the neutral gas fraction of the intergalactic medium. While distinguishing between these two scenarios may be extremely challenging, by framing the problem this way we remove the uncertainty of the halo mass from Ly alpha-based tests of reionization. We finally derive a new method by which to estimate the dust content of galaxies, based purely upon the observed Ly alpha and UV LFs. These data are characterized by an exponential with an e-folding scale of z(EBV) approximate to 3.4.
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| 9. |
- Hayes, Matthew, et al.
(författare)
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THE LYMAN ALPHA REFERENCE SAMPLE : EXTENDED LYMAN ALPHA HALOS PRODUCED AT LOW DUST CONTENT
- 2013
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Ingår i: Astrophysical Journal Letters. - 2041-8205 .- 2041-8213. ; 765:2, s. L27-
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Tidskriftsartikel (refereegranskat)abstract
- We report on new imaging observations of the Lyman alpha emission line (Ly alpha), performed with the Hubble Space Telescope, that comprise the backbone of the Lyman alpha Reference Sample. We present images of 14 starburst galaxies at redshifts 0.028 < z < 0.18 in continuum-subtracted Ly alpha, H alpha, and the far ultraviolet continuum. We show that Ly alpha is emitted on scales that systematically exceed those of the massive stellar population and recombination nebulae: as measured by the Petrosian 20% radius, RP20, Ly alpha radii are larger than those of H alpha by factors ranging from 1 to 3.6, with an average of 2.4. The average ratio of Ly alpha-to-FUV radii is 2.9. This suggests that much of the Ly alpha light is pushed to large radii by resonance scattering. Defining the Relative Petrosian Extension of Ly alpha compared to H alpha, xi(Ly alpha) = R-P20(Ly alpha)/R-P20(H alpha), we find xi(Ly alpha) to be uncorrelated with total Ly alpha luminosity. However, xi(Ly alpha) is strongly correlated with quantities that scale with dust content, in the sense that a low dust abundance is a necessary requirement (although not the only one) in order to spread Ly alpha photons throughout the interstellar medium and drive a large extended Ly alpha halo.
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| 10. |
- Hayes, Matthew, et al.
(författare)
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THE LYMAN ALPHA REFERENCE SAMPLE. II. HUBBLE SPACE TELESCOPE IMAGING RESULTS, INTEGRATED PROPERTIES, AND TRENDS
- 2014
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Ingår i: Astrophysical Journal. - 0004-637X .- 1538-4357. ; 782:1
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Tidskriftsartikel (refereegranskat)abstract
- We report new results regarding the Ly alpha output of galaxies, derived from the Lyman Alpha Reference Sample, and focused on Hubble Space Telescope imaging. For 14 galaxies we present intensity images in Ly alpha, H alpha, and UV, and maps of H alpha/H beta, Ly alpha equivalent width (EW), and Ly alpha/H alpha. We present Ly alpha and UV radial light profiles and show they are well-fitted by Sersic profiles, but Ly alpha profiles show indices systematically lower than those of the UV (n approximate to 1-2 instead of greater than or similar to 4). This reveals a general lack of the central concentration in Ly alpha that is ubiquitous in the UV. Photometric growth curves increase more slowly for Ly alpha than the far ultraviolet, showing that small apertures may underestimate the EW. For most galaxies, however, flux and EW curves flatten by radii approximate to 10 kpc, suggesting that if placed at high-z only a few of our galaxies would suffer from large flux losses. We compute global properties of the sample in large apertures, and show total Ly alpha luminosities to be independent of all other quantities. Normalized Ly alpha throughput, however, shows significant correlations: escape is found to be higher in galaxies of lower star formation rate, dust content, mass, and nebular quantities that suggest harder ionizing continuum and lower metallicity. Six galaxies would be selected as high-z Ly alpha emitters, based upon their luminosity and EW. We discuss the results in the context of high-z Ly alpha and UV samples. A few galaxies have EWs above 50 angstrom, and one shows f(esc)(Ly alpha) of 80%; such objects have not previously been reported at low-z.
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