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- Courteille, O., et al.
(författare)
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Face validity of VIS-Ed : A visualization program for teaching medical students and residents the biomechanics of cervical spine trauma
- 2013
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Ingår i: Medicine Meets Virtual Reality 20. - : IOS Press. - 9781614992080 ; 184, s. 96-102
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Konferensbidrag (refereegranskat)abstract
- This RCT study aimed to investigate if VIS-Ed (Visualization through Imaging and Simulation - Education) had the potential to improve medical student education and specialist training in clinical diagnosis and treatment of trauma patients. The participants' general opinion was reported as high in both groups (lecture vs. virtual patient (VP)). Face validity of the VIS-Ed for cervical spine trauma was demonstrated and the VP group reported higher stimulation and engagement compared to the lecture group. No significant difference in the knowledge test between both groups could be observed, confirming our null hypothesis that VIS-Ed was on par with a lecture.
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- Courteille, O., et al.
(författare)
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Mixed Virtual Reality Simulation -Taking Endoscopic Simulation One Step Further
- 2011
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Ingår i: Medicine Meets Virtual Reality 18. - : IOS Press. - 9781607507062 - 9781607507055 ; 163, s. 144-6
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Konferensbidrag (refereegranskat)abstract
- This pilot study aimed to assess medical students' appraisals of a "mixed" virtual reality simulation for endoscopic surgery (with a virtual patient case in addition to a virtual colonoscopy) as well as the impact of this simulation set-up on students' performance. Findings indicate that virtual patients can enhance contextualization of simulated endoscopy and thus facilitate an authentic learning environment, which is important in order to increase motivation.
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- Hedman, E., et al.
(författare)
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Effectiveness of Internet-based cognitive behaviour therapy for panic disorder in routine psychiatric care
- 2013
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Ingår i: Acta Psychiatrica Scandinavica. - : Wiley. - 0001-690X .- 1600-0447. ; 128:6, s. 457-467
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Tidskriftsartikel (refereegranskat)abstract
- ObjectiveGuided Internet-based cognitive behaviour therapy (ICBT) for panic disorder has been shown to be efficacious in several randomized controlled trials. However, the effectiveness of the treatment when delivered within routine psychiatric care has not been studied. The aim of this study was to investigate the effectiveness of ICBT for panic disorder within the context of routine psychiatric care. MethodWe conducted a cohort study investigating all patients (n=570) who had received guided ICBT for panic disorder between 2007 and 2012 in a routine care setting at an out-patient psychiatric clinic providing Internet-based treatment. The primary outcome measure was the Panic Disorder Severity Scale-Self-report (PDSS-SR). ResultsParticipants made large improvements from screening and pretreatment assessments to posttreatment (Cohen's d range on the PDSS-SR=1.07-1.55). Improvements were sustained at 6-month follow-up. ConclusionThis study suggests that ICBT for panic disorder is as effective when delivered in a routine care context as in the previously published randomized controlled trials.
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- Hedman, J., et al.
(författare)
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Applying a PCR inhibitor tolerant DNA polymerase blend in forensic DNA profiling
- 2011
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Ingår i: Forensic Science International: Genetics, Supplement Series. - : Elsevier. - 1875-1768. ; 3:1, s. e349-e350
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Tidskriftsartikel (refereegranskat)abstract
- Crime scene samples often contain extraneous compounds that may interfere with PCR-based DNA analysis, resulting in imbalanced, partial or blank/negative DNA profiles. Customising the chemical content of the PCR reaction is a strategy that may increase PCR inhibitor tolerance without manipulating the sample. We have validated a modified version of AmpFlSTR SGM Plus, replacing AmpliTaq Gold DNA polymerase with a customised blend of two alternative polymerases, ExTaq Hot Start and PicoMaxx High Fidelity. Allele calls are identical to standard analysis. Stutter sizes and balance values are indistinguishable. The modified chemistry provides increased resistance to PCR inhibitors, resulting in an elevated number of detected alleles for various problematic crime scene samples.
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- Hedman, J., et al.
(författare)
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Evaluation of four new forensic DNA profiling kits on complex crime scene stains
- 2011
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Ingår i: Book of Abstracts. ; , s. 161-
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Konferensbidrag (refereegranskat)abstract
- In 2009–2010, several forensic DNA profiling kits accustomed for Europe and the Prüm Treaty were commerciallyreleased. The manufacturers have made efforts to increase the PCR inhibitor tolerance compared to olderkits, as shown by their increased resistance to known inhibitors such as humic acid and hematin. However, theinhibitor content in true crime scene stains is more complex. Inhibitors may be unknown or not well characterisedand various troublesome compounds may be mixed.Here we evaluate four new 15 STR-marker profiling kits on 29 inhibited crime scene stains from routine caseworkwith DNA concentrations ranging from 0.026 to 0.11 ng/μL. For AmpFℓSTR SGM Plus, used as reference,analysis of 7 samples generated negative/blank DNA profiles, whereas 22 samples produced partial profiles.The four investigated kits were AmpFℓSTR NGM (Applied Biosystems), PowerPlex ESI 16, PowerPlex ESX 16(Promega) and Investigator ESSplex (Qiagen). All four new kits produced DNA profiles of significantly improvedquality compared to AmpFℓSTR SGM Plus. No profiles came out negative/blank. However, the kits were affectedby the complex samples and often failed to produce complete profiles. Matrices such as cigarette butts andmoist snuff seemed especially troublesome. The new kits have raised the bar for PCR inhibitor tolerance, butthe problem still needs to be considered.
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- Hedman, J., et al.
(författare)
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Evaluation of three new forensic DNA profiling kits on PCR-inhibitory crime scene samples
- 2011
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Ingår i: Forensic Science International: Genetics, Supplement Series. - : Elsevier. - 1875-1768. ; 3:1, s. e457-e458
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Tidskriftsartikel (refereegranskat)abstract
- In 2009–2010, several forensic DNA profiling kits customised for Europe and the Prüm Treaty were commercially released. The manufacturers have made efforts to increase the PCR inhibitor tolerance compared to previous kits, as shown by their increased resistance to known molecular inhibitors such as humic acid and haematin. We have evaluated three new 15 STR-marker profiling kits (AmpFlSTR NGM, PowerPlex ESI16 and PowerPlex ESX16) on various PCR-inhibitory crime scene samples. All three kits produced usable DNA profiles from most samples. However, the kits were affected by inhibitory compounds from some of the samples, resulting in partial DNA profiles.
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