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Träfflista för sökning "WFRF:(Heiberg T) srt2:(2000-2004)"

Sökning: WFRF:(Heiberg T) > (2000-2004)

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1.
  • Bruder, CEG, et al. (författare)
  • High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH
  • 2001
  • Ingår i: Human Molecular Genetics. - Oxford, United Kingdom : Oxford University Press. - 0964-6906 .- 1460-2083. ; 1, s. 271-
  • Tidskriftsartikel (refereegranskat)abstract
    • Neurofibromatosis type 2 (NF2) is an autosomal dominant disorder whose hallmark is bilateral vestibular schwannoma. It displays a pronounced clinical heterogeneity with mild to severe forms. The NF2 tumor suppressor (merlin/schwannomin) has been cloned and extensively analyzed for mutations in patients with different clinical variants of the disease. Correlation between the type of the NF2 gene mutation and the patient phenotype has been suggested to exist. However, several independent studies have shown that a fraction of NF2 patients with various phenotypes have constitutional deletions that partly or entirely remove one copy of the NF2 gene. The purpose of this study was to examine a 7 Mb interval in the vicinity of the NF2 gene in a large series of NF2 patients in order to determine the frequency and extent of deletions. A total of 116 NF2 patients were analyzed using high-resolution array-comparative genomic hybridization (CGH) on an array covering at least 90% of this region of 22q around the NF2 locus. Deletions, which remove one copy of the entire gene or are predicted to truncate the schwannomin protein, were detected in 8 severe, 10 moderate and 6 mild patients. This result does not support the correlation between the type of mutation affecting the NF2 gene and the disease phenotype. This work also demonstrates the general usefulness of the array-CON methodology for rapid and comprehensive detection of small (down to 40 kb) heterozygous and/or homozygous deletions occurring in constitutional or tumor-derived DNA.
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2.
  • Heiberg, T., et al. (författare)
  • An agent-based architecture for customer services management and product search
  • 2002
  • Ingår i: Informatica (Vilnius). - 0868-4952 .- 1822-8844. ; 13:4, s. 441-454
  • Tidskriftsartikel (refereegranskat)abstract
    • The amount of products and services available over the Internet increases significantly and it soon becomes beyond users ability to analyze and compare them. At the same time the number of potential customers available via the Internet also increases dramatically and starts to be beyond the service providers ability to perform efficient targeted marketing. A possible way for relaxing the above-mentioned limitations could be in usage of electronic assistants, both for customers and providers. Such assistants may serve as mediators for commercial Internet-based activity. Software agents could play role of such mediators representing customers and providers in the network. In this paper we present our experience and a solution to using agent technology in customer services management for mobile users. The solution is intended to increase granularity and personalization in targeted advertising while ensuring customer privacy. The proposed solution has been implemented in a prototype system for providing services for,users of mobile devices.
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