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Sökning: WFRF:(Heikkila K) > (2000-2004)

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  • Heikkila, P, et al. (författare)
  • Animal models of Alport syndrome: advancing the prospects for effective human gene therapy
  • 2000
  • Ingår i: Experimental nephrology. - : S. Karger AG. - 1018-7782 .- 1660-2129. ; 8:1, s. 1-7
  • Tidskriftsartikel (refereegranskat)abstract
    • Several animal models for Alport syndrome have been described. These are available for studies on the pathogenetic mechanisms of the disease, as well as for the development of new technologies for gene therapy in this progressive hereditary kidney disease. This review summarizes current knowledge on the molecular basis of Alport syndrome, and on the animal models which all remarkably well resemble the human disease. Recent work aimed at the development of gene therapy, including hurdles and progress are discussed.
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  • Tynninen, O, et al. (författare)
  • Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
  • 2002
  • Ingår i: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 86:12, s. 1905-1908
  • Tidskriftsartikel (refereegranskat)abstract
    • The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.
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