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- Ekström, Simon, et al.
(författare)
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Polymeric integrated selective enrichment target (ISET) for solid-phase-based sample preparation in MALDI-TOF MS
- 2007
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Ingår i: Journal of Mass Spectrometry. - : Wiley. - 1076-5174 .- 1096-9888. ; 42:11, s. 1445-1452
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Tidskriftsartikel (refereegranskat)abstract
- d A polymer microfabricated proteomic sample preparation and MALDI MS sample presentation device, the integrated selective enrichment target (ISET), comprising an array of perforated nanovials is reported. Each perforated nanovial can be filled with selective extraction media (microbeads) for purification and concentration of protein/peptides prior to matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS). The main areas covered are the influence of the molding-process-induced surface roughness and how to address the lack of inherent conductivity in the polyetheretherketone (PEEK) material for optimal MALDI MS readout. Application of the disposable polymeric ISET devices for solid-phase extraction and phosphopeptide capture is also demonstrated.
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| 2. |
- Helldin, Lars, et al.
(författare)
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Experience of quality of life and attitude to care and treatment in patients with schizophrenia : Role of cross-sectional remission
- 2008
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Ingår i: International journal of psychiatry in clinical practice (Print). - : Informa UK Limited. - 1365-1501 .- 1471-1788. ; 12:2, s. 97-104
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Tidskriftsartikel (refereegranskat)abstract
- Objective The concept of cross-sectional remission was investigated in a sample of patients with schizophrenia. A total of 243 patients were tested for quality of life, burden and handicap, insight and satisfaction with the care provided in an epidemiological study. The question addressed was if remission is of importance for outcome. Methods Cross-sectional remission was defined by applying the symptom criteria of remission, where none of eight selected PANSS items should exceed 3 points. Out of 243 patients, 38% were in met cross-sectional remission. Quality of life was assessed with the MOS SF-36 and the Rosser Index. The Patients' understanding of their illness was assessed based on symptoms and disorder insight. Finally, attitudes to care and, health service were assessed by the UKU/Consumer Satisfaction Questionnaire and the Drug Attitude Inventory. Results Patients who were in cross-sectional remission reported higher quality of life and reduced burden related to the disorder, a greater level of insight into their symptoms and the illness, and a more positive attitude to treatment, including drugs. Conclusion This study implies that remission, here expressed in terms of cross-sectional remission, is of importance for patients' well-being. Patients who had no interference from symptoms in their daily functioning found their life better, had a superior insight and were more positive to treatment.
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| 6. |
- Helldin, Lars, 1956-
(författare)
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The Importance of Remission in the Treatment of Patients with Schizophrenia Spectrum Syndromes : Clinical Long-term Investigation of Psychosis in Sweden
- 2009
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Doktorsavhandling (övrigt vetenskapligt/konstnärligt)abstract
- The goal of this thesis was to investigate the hypothesis whether symptomatic remission for patents with schizophrenia spectrum syndrome would provide practical and qualitative benefits for patients and for society. The first work (Paper I) examines the relationship between cross-sectional remission and the patients’ practical resources. The patients’ adaptations to society as well as their employments, living situations and social networks were studied. Their activity of daily living resources are described in terms of the extent to which they could pursue various undertakings autonomously. Their need for care was also studied. The results showed that the patient group that had achieved remission scored better on all of the variables studied, had better resources and less need for medical care and sheltered housing. The second work (Paper II) analysed the relationship between cross-sectional remission and quality of life, burden placed on patients by the illness, and the patients’ satisfaction with care received and with their medication, and also their capacity for understanding their symptoms and their illness. Even the results of this study showed that the patients in the remission group had a better quality of life, bore a lesser burden, were more satisfied with their care and had better insight into their illness. The third work (Paper III) studied the patients’ neurocognitive capacity to see if a higher capacity resulted in a higher percentage of patients achieving remission. The results showed unequivocally that the patients in remission consistently performed better in the cognitive tests. They also showed that they even had a larger vocabulary indicating a higher premorbid capacity. The fourth work (Paper IV) followed the patients over an average time of 65 months. In this study, the patients’ needs for medical care and for housing were investigated. Patients who were not in cross-sectional remission at baseline had for all the measured variables a higher consumption than those in remission even if the differences were not significant, except for patients who lived in sheltered housing and who had greater need for medical care. Taking all these findings together, the result of this thesis shows that the attainment of remission provides practical and qualitative advantages to the patients and to society.
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| 7. |
- Hjärthag, Fredrik, 1973-, et al.
(författare)
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Psychometric Properties of the Burden Inventory for Relatives of Persons with Psychotic Disturbances
- 2008
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Ingår i: Psychological Reports. - : Ammons Scientific. - 0033-2941 .- 1558-691X. - 9789170632273 ; 103, s. 323-335
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Tidskriftsartikel (refereegranskat)abstract
- Earlier studies have shown that close relatives are heavily burdened when a family member has schizophrenia. The current purpose was twofold, (1) to examine the psychometric properties for a test of the burden of family members, one used in Swedish clinical practice (the Care Burden Scale for Relatives) and (2) develop a shortened version with the same or better psychometric properties. Ninety-nine close relatives, 34 men and 65 women, of the same number of patients who had been diagnosed either with schizophrenia or with schizoaffective disorder, were studied. Participants completed the Care Burden Scale for Relatives and a visual analogue scale measuring perceived global burden on which the total burden was assessed. Patients of the close relatives were assessed on clinical tests often used in the psychiatric care, in an attempt to validate the external criteria, such as severity of symptoms and level of functioning. The resulting instrument, Burden Inventory for Relatives of persons with Psychotic disturbances, showed good psychometric properties which simplifies data collection from relatives of patients with psychotic disturbances. In this study, relatives of those patients not in remission evinced a significant greater family burden.
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| 8. |
- Karilampi, Ulla, et al.
(författare)
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Verbal learning in schizopsychotic outpatients and healthy volunteers as a function of cognitive performance levels
- 2007
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Ingår i: Archives of clinical neuropsychology. - : Oxford University Press (OUP). - 0887-6177 .- 1873-5843. ; 22:2, s. 161-174
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Tidskriftsartikel (refereegranskat)abstract
- OBJECTIVE The aim was to analyze and compare neurocognitive test profiles related to different levels of verbal learning performance among schizopsychotic patients and healthy volunteers. METHOD A single-center patient cohort of 196 participants was compared with an equal-sized volunteer group to form three cognitive subgroups based on the shared verbal learning performance. RESULTS 43.9% of the patients had normal learning ability. Despite this, all patients underperformed the volunteers on all subtests with the exception of working memory, and, for those with high learning ability, even verbal facility. All patients also presented equally poor visuomotor processing speed/efficacy. CONCLUSION A global neurocognitive retardation of speed-related processing in schizophrenia is suggested.
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| 9. |
- Lasser, Robert A, et al.
(författare)
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Remission in schizophrenia: Applying recent consensus criteria to refine the concept
- 2007
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Ingår i: Schizophrenia Research. - : Elsevier BV. - 0920-9964 .- 1573-2509. ; 96:1, s. 223-231
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Tidskriftsartikel (refereegranskat)abstract
- Although the concept of remission has been widely accepted and utilized in depression and anxiety disorders, there has been much less emphasis on defining remission in schizophrenia. Recently, an expert consensus definition of remission in schizophrenia was proposed along specific operational criteria for the attainment of remission focusing on the three core dimensions of psychopathology identified within schizophrenia: psychoticism, disorganization and negative symptoms. To date, the criteria have been applied retrospectively to several clinical studies, and these have demonstrated that the proposed definition of remission correlates significantly with established measures of symptom severity, functioning and quality of life, and appears achievable for a significant proportion of patients receiving at least 3 months of pharmacotherapy. In this article we extend the notion of remission to include an examination of the possible association of several modifiable and unmodifiable factors and co-morbidities on remission status. We also propose an investigation into the likelihood of different patient populations in achieving remission as well as assessing the impact of remission on health care costs and family burden. Since cognitive dysfunction and negative symptoms may be strongly correlated with a lower likelihood of achieving remission, we recommend retrospective and/or prospective studies to determine the relationship between neurocognitive status and the predominance of negative symptoms at treatment start and the probability of achieving remission. Taken together, these studies should help identify key predictors of remission, further define the remitted state, reduce therapeutic pessimism, raise treatment expectations and chart a strategy for further research in this important area.
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